Mitochondrial genetic diversity and phylogenetic relationships of Echinococcus multilocularis in Europe

Santoro, Azzurra; Santolamazza, Federica; Cacciò, Simone M.; La Rosa, Giuseppe; Antolová, Daniela; Auer, Herbert; Bagrade, Guna; Bandelj, Petra; Basso, Walter; Beck, Relja; Citterio, Carlo V.; Davidson, Rebecca K.; Deksne, Gunita; Frey, Caroline F.; Fuglei, Eva; Glawischnig, Walter; Gottstein, Bruno; Harna, Jiří; Huus Petersen, Heidi; Karamon, Jacek; Jansen, Famke; Jarošová, Júlia; Jokelainen, Pikka; Lundström-Stadelmann, Britta; Maksimov, Pavlo; Miljević, Milan; Miterpáková, Martina; Moks, Epp; Origgi, Francesco; Ozolina, Zanda; Ryser, Marie-Pierre; Romig, Thomas; Šarkūnas, Mindaugas; Scorrano, Nathalie; Saarma, Urmas; Šnábel, Viliam; Sréter, Tamás; Umhang, Gèrald; Vengušt, Gorazd; Žele Vengušt, Diana; Casulli, Adriano

doi:10.1016/j.ijpara.2024.01.003

Cited by 8 publications

(3 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Scientific research, epidemiological investigations, and early disease detection rely on molecular techniques, especially PCR, known for their sensitivity and specificity [ 66 ]. Additionally, these techniques enable us to understand genetic variability and geographic distribution so that specific interventions can be tailored to particular regions [ 67 ]. A single-tube nested PCR (STNPCR), designed to detect the COI gene, was evaluated for its efficacy as an indicator of Echinococcus spp.…”

Section: Methods For Diagnosis Of Cystic Echinococcosis In Intermedia...mentioning

confidence: 99%

“…Genetic diversity and evolution can be studied through the ability of Echinococcus spp. to amplify small amounts of genomic DNA [ 67 ].…”

Section: Methods For Diagnosis Of Cystic Echinococcosis In Intermedia...mentioning

confidence: 99%

“…The phylogenetic analysis of mitochondrial genes is an effective tool for understanding the evolution of genotypes. Besides revealing genetic relationships, it is possible to build a phylogenetic tree useful to distinguish genotypes and show patterns of infection and transmission [ 67 ]. Genotyping mitochondrial genes is a significant component of epidemiological research.…”

Section: Methods For Diagnosis Of Cystic Echinococcosis In Intermedia...mentioning

confidence: 99%

See 2 more Smart Citations

Advances in Detecting Cystic Echinococcosis in Intermediate Hosts and New Diagnostic Tools: A Literature Review

Hajjafari,

Sadr,

Santucciu

et al. 2024

Veterinary Sciences

View full text Add to dashboard Cite

Cystic echinococcosis (CE) is a zoonotic disease affecting humans and animals. Despite a lack of clarity about many details of parasite–intermediate host interactions, the nature of the immune responses triggered by hydatid infection has revealed new perspectives. This study discusses the latest advances in elucidating the immunologic mechanism of echinococcosis and its detection and potential approaches to enhance serodiagnosis accuracy. Moreover, nanobiosensors have been evaluated according to their potential to improve treatment efficiency and aid in an early diagnosis of cystic echinococcosis. The serum of an intermediate host can diagnose CE by analyzing antibodies induced by Echinococcus granulosus. Among the most notable features of this method are its noninvasive ability and high sensitivity, both of which make it an excellent tool for clinical diagnosis. Several serological tests, including ELISAs and immunoblotting, can detect these antibodies to assess the disease’s state and determine the treatment outcome. A thorough understanding of what cross-reactivity means and the stage of the disease are crucial to interpreting serological results. Nanobiosensors have also proven better than conventional biosensors in detecting hydatid cysts. Additionally, they are highly sensitive and versatile when detecting specific biomarkers, improving diagnostic accuracy. These immunomodulatory molecules, induced by E. granulosus, are a good candidate for diagnosing cystic echinococcosis because they alter intermediate host immune responses. Hydatid cyst detection is also enhanced through nanobiosensors, which provide better accuracy.

show abstract

Section: Methods For Diagnosis Of Cystic Echinococcosis In Intermedia...mentioning

confidence: 99%

“…Genetic diversity and evolution can be studied through the ability of Echinococcus spp. to amplify small amounts of genomic DNA [ 67 ].…”

Section: Methods For Diagnosis Of Cystic Echinococcosis In Intermedia...mentioning

confidence: 99%

Section: Methods For Diagnosis Of Cystic Echinococcosis In Intermedia...mentioning

confidence: 99%

See 1 more Smart Citation

Advances in Detecting Cystic Echinococcosis in Intermediate Hosts and New Diagnostic Tools: A Literature Review

Hajjafari,

Sadr,

Santucciu

et al. 2024

Veterinary Sciences

View full text Add to dashboard Cite

show abstract

Neglected cystic and alveolar echinococcosis

Casulli,

Santoro,

Laurimäe

2025

Neglected Zoonoses and Antimicrobial Resistance

View full text Add to dashboard Cite

Challenging the phylogenetic relationships among Echinococcus multilocularis isolates from main endemic areas

Lallemand,

Oyhenart,

Valot

et al. 2024

International Journal for Parasitology

View full text Add to dashboard Cite

Mitochondrial genetic diversity and phylogenetic relationships of Echinococcus multilocularis in Europe

Cited by 8 publications

References 92 publications

Advances in Detecting Cystic Echinococcosis in Intermediate Hosts and New Diagnostic Tools: A Literature Review

Advances in Detecting Cystic Echinococcosis in Intermediate Hosts and New Diagnostic Tools: A Literature Review

Neglected cystic and alveolar echinococcosis

Challenging the phylogenetic relationships among Echinococcus multilocularis isolates from main endemic areas

Contact Info

Product

Resources

About