Mitochondrial hijacking: A potential mechanism for SARS-CoV-2 to impair female fertility

Sun, Jun; Liu, Qiong; Zhang, Xinling; Dun, Shu; Liu, Li

doi:10.1016/j.mehy.2022.110778

Cited by 3 publications

(1 citation statement)

References 58 publications

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“…Furthermore, both amyloid-β and tau, two pathological hallmarks of Alzheimer’s disease (AD), are known to bind to mitochondria [ 66 , 67 , 68 ], and have been shown to propagate between cells via TNTs [ 69 , 70 ]. These findings also have implications for other disease-related cargo that are known to bind to mitochondria, such as SARS-CoV-2 [ 71 ], and suggest that under specific disease conditions, mitochondria may be hijacked as a means to facilitate cell-to-cell transfer of pathogens in the brain. However, direct evidence for intercellular mitochondrial transfer as a means of spreading disease-associated proteinopathy in the brain is still lacking.…”

Section: Effects Of Mitochondrial Transfer In the Brainmentioning

confidence: 99%

Mitochondria Transfer in Brain Injury and Disease

Fairley

Grimm

2022

Cells

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Intercellular mitochondria transfer is a novel form of cell signalling in which whole mitochondria are transferred between cells in order to enhance cellular functions or aid in the degradation of dysfunctional mitochondria. Recent studies have observed intercellular mitochondria transfer between glia and neurons in the brain, and mitochondrial transfer has emerged as a key neuroprotective mechanism in a range of neurological conditions. In particular, artificial mitochondria transfer has sparked widespread interest as a potential therapeutic strategy for brain disorders. In this review, we discuss the mechanisms and effects of intercellular mitochondria transfer in the brain. The role of mitochondrial transfer in neurological conditions, including neurodegenerative disease, brain injury, and neurodevelopmental disorders, is discussed as well as therapeutic strategies targeting mitochondria transfer in the brain.

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Section: Effects Of Mitochondrial Transfer In the Brainmentioning

confidence: 99%

Mitochondria Transfer in Brain Injury and Disease

Fairley

Grimm

2022

Cells

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Methodology for identifying and tracking social media misinformation in tweets about the impact of the COVID-19 pandemic on reproductive health

Хакимова

Золотарев

2022

Preprint

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The purpose of the study was to develop the methodology identifying and tracking social media misinformation in tweets about the impact of the coronavirus and COVID-vaccine on reproductive health, one of the reasons for which is the lack of awareness about aspects of the coronavirus infection. We use a combination of machine and expert methods, and use the latest scientific articles as the standard for detecting disinformation. The proposed methodology includes the study of scientific articles as a source of reliable truthful information about the topic (information standard) and Twitter messages (assessment of information compliance with the standard). The result of the study is a methodology for detecting disinformation in the messages of social network users. Based on this methodology, the following aspects of the problem have been developed: 1) the formation of a scientific standard; 2) the principle of comparing the directions of scientific research and discussions on Twitter; 3) the principle of contextual comparison of user and scientific ideas about problems. An original methodology for identifying disinformation in social networks is proposed. In contrast to existing works, principles based on the processing of information from the content of scientific articles and messages from social networks are formulated.

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Mitochondria in COVID-19: from cellular and molecular perspective

Rurek

2024

Front. Physiol.

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The rapid development of the COVID-19 pandemic resulted in a closer analysis of cell functioning during β-coronavirus infection. This review will describe evidence for COVID-19 as a syndrome with a strong, albeit still underestimated, mitochondrial component. Due to the sensitivity of host mitochondria to coronavirus infection, SARS-CoV-2 affects mitochondrial signaling, modulates the immune response, modifies cellular energy metabolism, induces apoptosis and ageing, worsening COVID-19 symptoms which can sometimes be fatal. Various aberrations across human systems and tissues and their relationships with mitochondria were reported. In this review, particular attention is given to characterization of multiple alterations in gene expression pattern and mitochondrial metabolism in COVID-19; the complexity of interactions between SARS-CoV-2 and mitochondrial proteins is presented. The participation of mitogenome fragments in cell signaling and the occurrence of SARS-CoV-2 subgenomic RNA within membranous compartments, including mitochondria is widely discussed. As SARS-CoV-2 severely affects the quality system of mitochondria, the cellular background for aberrations in mitochondrial dynamics in COVID-19 is additionally characterized. Finally, perspectives on the mitigation of COVID-19 symptoms by affecting mitochondrial biogenesis by numerous compounds and therapeutic treatments are briefly outlined.

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Mitochondrial hijacking: A potential mechanism for SARS-CoV-2 to impair female fertility

Cited by 3 publications

References 58 publications

Mitochondria Transfer in Brain Injury and Disease

Mitochondria Transfer in Brain Injury and Disease

Methodology for identifying and tracking social media misinformation in tweets about the impact of the COVID-19 pandemic on reproductive health

Mitochondria in COVID-19: from cellular and molecular perspective

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