“…The published evidence suggests that mitochondrial morphogenesis proteins, perhaps through direct modulation of BCL-2 family proteins, participate in this process. Since mitochondrial morphogenesis proteins, including Mfn2, Fis1 and Drp1, can interact with BCL-2 family proteins, 24,58,59 one could predict that direct molecular interactions between these proteins (e.g., Drp1, Mfn2) and BCL-2 family members take part in the regulation of the mitochondrial steps in apoptosis. Immunoprecipitation studies demonstrated that in healthy cells Mfn1 and Mfn2 interact with Bak, 54 yet upon induction of apoptosis the interaction of Bak with Mfn2 was no longer detectable.…”