2000
DOI: 10.1093/humrep/15.suppl_2.148
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Mitochondrial morphology during preimplantational human embryogenesis

Abstract: The structure, distribution, and function of mitochondria during human oogenesis and early development is reported. Oogonia show a sparse and even distribution of mitochondria, which are oval or elongated. Except around nuclei, growing oocytes from small antral follicles have more dense rounded or oval mitochondria, associated with the rough endoplastic reticulum. Mitochondria in fully grown, germinal vesicle (GV) oocytes present an inert appearance, with a dense matrix and a few arch-like or transverse crista… Show more

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Cited by 194 publications
(139 citation statements)
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“…Increased oxidative stress in aged murine oocytes has been linked to low ooplasmic ATP levels [22]. Undifferentiated appearance of mitochondria in MII oocytes has previously been described; therefore, our finding is consistent with prior reports [12,17]. In MII oocytes mitochondria have a round shape with few well defined cristae.…”
Section: Discussionsupporting
confidence: 92%
“…Increased oxidative stress in aged murine oocytes has been linked to low ooplasmic ATP levels [22]. Undifferentiated appearance of mitochondria in MII oocytes has previously been described; therefore, our finding is consistent with prior reports [12,17]. In MII oocytes mitochondria have a round shape with few well defined cristae.…”
Section: Discussionsupporting
confidence: 92%
“…Besides regulating cardiac differentiation, the increased expression of cardiac transcription factors promotes mitochondrial function and cellular organization. 12,22,23 In stem cell-derived cardiomyocytes, downregulation of genes with roles in mitochondrial fission or inhibition of fusion led to intracellular and intercellular networks facilitating expansion of the cardiogenic phenotype. These cell-to-cell connections enabling the transport of mitochondria and leading to the acquisition of a cardiomyogenic phenotype by progenitor cells had been observed previously.…”
Section: Discussionmentioning
confidence: 99%
“…However, in human, the metabolic switch is not complete until the blastocyst stage (Sathananthan & Trounson 2000). This glycolytic metabolism requires supplies of glucose and simple sugars.…”
Section: Nutrientsmentioning
confidence: 99%
“…2A). The mature mitochondria can now use oxygen and glucose in glycolysis to provide ATP for further embryo development (Sathananthan & Trounson 2000). In mice, this is evident with the timing of embryo oxygen consumption, which peaks at the blastocyst stage (Leese 2012 Oxidative metabolism Glycolytic metabolism…”
Section: Nutrientsmentioning
confidence: 99%