2001
DOI: 10.1016/s0047-6374(01)00259-7
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Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans

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Cited by 110 publications
(79 citation statements)
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References 34 publications
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“…Third, the average life span of the mev-1 worms was significantly lower than that of N2. The proportional decrease in life span from mev-1 to N2 ancestral control worms ($17%) was slightly lower than reported values, which vary from 20 to 49% (Ishii et al 1990;Adachi et al 1998;Hartman et al 2001;Yanase et al 2002;Cai et al 2008), likely in part because of our very small sample size (N = 5/replicate). Additionally, mev-1 worms tended to develop more slowly, as documented by others (e.g., Ishii et al 1990;Yasuda et al 1999), although the development rates of the mev-1 worms were not different enough from the N2 that we had to lengthen the intervals between MA bottlenecks, as we have in previous studies (e.g., Baer et al 2010).…”
Section: Discussioncontrasting
confidence: 76%
See 1 more Smart Citation
“…Third, the average life span of the mev-1 worms was significantly lower than that of N2. The proportional decrease in life span from mev-1 to N2 ancestral control worms ($17%) was slightly lower than reported values, which vary from 20 to 49% (Ishii et al 1990;Adachi et al 1998;Hartman et al 2001;Yanase et al 2002;Cai et al 2008), likely in part because of our very small sample size (N = 5/replicate). Additionally, mev-1 worms tended to develop more slowly, as documented by others (e.g., Ishii et al 1990;Yasuda et al 1999), although the development rates of the mev-1 worms were not different enough from the N2 that we had to lengthen the intervals between MA bottlenecks, as we have in previous studies (e.g., Baer et al 2010).…”
Section: Discussioncontrasting
confidence: 76%
“…mev-1 nematodes have increased mitochondrial free radical production (Senoo-Matsuda et al 2001), elevated oxidative stress, and apoptosis (for review, Ishii et al 2007), and reduced life span and fecundity (Ishii et al 1990) in comparison to N2. The oxidative stress accompanying the mev-1 mutation is considered to be hypermutagenic (Hartman et al 2001;2004;Ishii et al 2005). However, age-matched mev-1 and N2 nematodes appear to have comparable metabolic rates as indicated by ATP content (Senoo-Matsuda et al 2001) and O 2 consumption rates (Yasuda et al 2010).…”
mentioning
confidence: 99%
“…Similar to hsp-6(RNAi), accumulation of autofluorescence and short life span have been observed in mutants of mev-1 (kn1) and gas-1 (fc2) (12,47,56,57). Therefore, it is possible that the main effect of a reduction of HSP-6 is on these proteins.…”
Section: Discussionmentioning
confidence: 88%
“…Sls1p is a mitochondrial membrane protein required for respiralived ⌬oxa1 (oxa1 ts ) rmp1-2 strain significantly modifies the life span of these strains. This result clearly estabtion (Rouillard et al 1996). Its precise function remains to be elucidated.…”
Section: Oxa1 Tsmentioning
confidence: 81%