Mitochondrial-nuclear co-evolution and its effects on OXPHOS activity and regulation

Bar-Yaacov, Dan; Blumberg, Dan G.; Mo, Dan

doi:10.1016/j.bbagrm.2011.10.008

Cited by 106 publications

(91 citation statements)

References 57 publications

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“…Coevolution of both DNAs is a fundamental process that preserves biological functionality and cell activity (51). Interaction between nDNA and mtDNA products is known to occur at different levels such as protein-protein interaction in oxidative phosphorylation (OXPHOS), protein-RNA interactions, and nuclear factor-mtDNA recognition sites interactions in the processes of replication and transcription (3,63,77). Epigenetic changes play a role in this cross talk being both instrument and recipient of informative flows between the two genomes.…”

Section: Epigenetic Cross Talk At the Dna Levelmentioning

confidence: 99%

The mitochondrial side of epigenetics

Castegna

Iacobazzi

Infantino

2015

Physiological Genomics

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The bidirectional cross talk between nuclear and mitochondrial DNA is essential for cellular homeostasis and proper functioning. Mitochondria depend on nuclear contribution for much of their functionality, but their activities have been recently recognized to control nuclear gene expression as well as cell function in many different ways. Epigenetic mechanisms, which tune gene expression in response to environmental stimuli, are key regulatory events at the interplay between mitochondrial and nuclear interactions. Emerging findings indicate that epigenetic factors can be targets or instruments of mitochondrial-nuclear cross talk. Additionally, the growing interest into mtDNA epigenetic modifications opens new avenues into the interaction mechanisms between mitochondria and nucleus. In this review we summarize the points of mitochondrial and nuclear reciprocal control involving epigenetic factors, focusing on the role of mitochondrial genome and metabolism in shaping epigenetic modulation of gene expression. The relevance of the new findings on the methylation of mtDNA is also highlighted as a new frontier in the complex scenario of mitochondrial-nuclear communication.

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Section: Epigenetic Cross Talk At the Dna Levelmentioning

confidence: 99%

The mitochondrial side of epigenetics

Castegna

Iacobazzi

Infantino

2015

Physiological Genomics

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“…2004; Bar‐Yaacov et al. 2012). The need for mitonuclear compatibility is fundamental (Mishmar et al.…”

Section: Introductionmentioning

confidence: 99%

Mitonuclear coevolution as the genesis of speciation and the mitochondrial DNA barcode gap

Hill

2016

Ecology and Evolution

149

178

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Mitochondrial genes are widely used in taxonomy and systematics because high mutation rates lead to rapid sequence divergence and because such changes have long been assumed to be neutral with respect to function. In particular, the nucleotide sequence of the mitochondrial gene cytochrome c oxidase subunit 1 has been established as a highly effective DNA barcode for diagnosing the species boundaries of animals. Rarely considered in discussions of mitochondrial evolution in the context of systematics, speciation, or DNA barcodes, however, is the genomic architecture of the eukaryotes: Mitochondrial and nuclear genes must function in tight coordination to produce the complexes of the electron transport chain and enable cellular respiration. Coadaptation of these interacting gene products is essential for organism function. I extend the hypothesis that mitonuclear interactions are integral to the process of speciation. To maintain mitonuclear coadaptation, nuclear genes, which code for proteins in mitochondria that cofunction with the products of mitochondrial genes, must coevolve with rapidly changing mitochondrial genes. Mitonuclear coevolution in isolated populations leads to speciation because population‐specific mitonuclear coadaptations create between‐population mitonuclear incompatibilities and hence barriers to gene flow between populations. In addition, selection for adaptive divergence of products of mitochondrial genes, particularly in response to climate or altitude, can lead to rapid fixation of novel mitochondrial genotypes between populations and consequently to disruption in gene flow between populations as the initiating step in animal speciation. By this model, the defining characteristic of a metazoan species is a coadapted mitonuclear genotype that is incompatible with the coadapted mitochondrial and nuclear genotype of any other population.

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“…Among the primary products of these mitochondrial genes are proteins that form complexes with proteins encoded by nuclear genes [21]. The mitonuclear complexes include four of the five functional units of the electron transport chain, the machinery in the inner-mitochondrial membrane that carries out oxidative phosphorylation (OXPHOS) reactions [22,23]. Mitochondria-encoded proteins and nuclear-encoded proteins must work in concert in forming functional complexes for efficient OXPHOS and energy production [24,25].…”

Section: Introductionmentioning

confidence: 99%

The mitonuclear compatibility hypothesis of sexual selection

Hill

Johnson

2013

Proc. R. Soc. B.

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Why females assess ornaments when choosing mates remains a central question in evolutionary biology. We hypothesize that the imperative for a choosing female to find a mate with nuclear oxidative phosphorylation (OXPHOS) genes that are compatible with her mitochondrial OXPHOS genes drives the evolution of ornaments. Indicator traits are proposed to signal the efficiency of OXPHOS function thus enabling females to select mates with nuclear genes that are compatible with maternal mitochondrial genes in the formation of OXPHOS complexes. Species-typical pattern of ornamentation is proposed to serve as a marker of mitochondrial type ensuring that females assess prospective mates with a shared mitochondrial background. The mitonuclear compatibility hypothesis predicts that the production of ornaments will be closely linked to OXPHOS pathways, and that sexual selection for compatible mates will be strongest when genes for nuclear components of OXPHOS complexes are Z-linked. The implications of this hypothesis are that sexual selection may serve as a driver for the evolution of more efficient cellular respiration.

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Mitochondrial-nuclear co-evolution and its effects on OXPHOS activity and regulation

Cited by 106 publications

References 57 publications

The mitochondrial side of epigenetics

The mitochondrial side of epigenetics

Mitonuclear coevolution as the genesis of speciation and the mitochondrial DNA barcode gap

The mitonuclear compatibility hypothesis of sexual selection

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