Mitochondrial Oxidative Substrate Selection in Porcine Bladder Smooth Muscle

Hardin, Christopher D.; Kleiber, Brian D.; Roberts, Tina M.

doi:10.1097/01.ju.0000091872.33814.70

Cited by 2 publications

(2 citation statements)

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“…It was shown that bladder smooth muscle has limited plasticity in mitochondrial substrate selection and excess lipid provision may induce lipotoxicity resulting in impaired detrusor function. 15 In the current study, we have demonstrated impaired bladder muscle contractility associated with HFD feeding and provided supportive evidence for bladder lipotoxicity.…”

Section: Discussionsupporting

confidence: 75%

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Changes of Bladder M_1,3 Muscarinic Receptor Expression in Rats Fed with Short‐Term/Long‐Term High‐Fat Diets

Lin

Wu²,

Chang

et al. 2017

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Section: Discussionsupporting

confidence: 75%

“…13,14 The susceptibility of bladder smooth muscle to lipotoxicity in metabolic syndrome has been demonstrated. 15 Thus the purpose of the current study was to investigate the possible detrimental effects of dietary obesity on the neuromuscular pathway controlling bladder contractile function.…”

Section: Introductionmentioning

confidence: 99%

Changes of Bladder M_1,3 Muscarinic Receptor Expression in Rats Fed with Short‐Term/Long‐Term High‐Fat Diets

Lin

Wu²,

Chang

et al. 2017

LUTS

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Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome

et al. 2007

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The metabolic syndrome and diabetes are associated with bladder dysfunction in many people. Peroxisome proliferator-activated receptors (PPARs) may play a role in the effects of the metabolic syndrome on bladder smooth muscle (BSM). The purpose of this study was to determine if there are gender and genetic differences in PPAR levels in BSM. We measured PPAR levels using quantitative PCR in BSM from male Yucatan swine and male and female Ossabaw Island swine, which is a model for the metabolic syndrome. Male Ossabaw swine had 0.732 +/- 0.111 the amount of PPAR-alpha mRNA as male Yucatan swine (P < 0.05), suggesting a genetic difference in PPAR-alpha levels. This difference may possibly contribute to the incidence of metabolic syndrome in the Ossabaw model compared to the Yucatan model. PPAR-delta mRNA was 2-fold higher in male Ossabaw swine than in female Ossabaw swine, with no significant differences in PPAR-alpha levels. However, PPAR-gamma mRNA was 4.067 +/- 0.134 times higher in female Ossabaw swine than in their male counterparts (P < 0.001). Changing the percentage of calories derived from fat did not alter any PPAR mRNA levels. Thus, PPAR-delta and PPAR-gamma mRNA levels in male and female Ossabaw swine BSM are not only different, but may also result in gender differences in lipid metabolism in bladder smooth muscle. We conclude that PPAR profiles in BSM may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.

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Mitochondrial Oxidative Substrate Selection in Porcine Bladder Smooth Muscle

Abstract: We conclude that BSM has modest plasticity of the pattern of mitochondrial substrate selection and excess lipid provision may be able to induce lipotoxicity in BSM, resulting in impaired detrusor function.

Cited by 2 publications

References 13 publications

Changes of Bladder M_1,3 Muscarinic Receptor Expression in Rats Fed with Short‐Term/Long‐Term High‐Fat Diets

Changes of Bladder M_1,3 Muscarinic Receptor Expression in Rats Fed with Short‐Term/Long‐Term High‐Fat Diets

Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome

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Mitochondrial Oxidative Substrate Selection in Porcine Bladder Smooth Muscle

Abstract: We conclude that BSM has modest plasticity of the pattern of mitochondrial substrate selection and excess lipid provision may be able to induce lipotoxicity in BSM, resulting in impaired detrusor function.

Cited by 2 publications

References 13 publications

Changes of Bladder M1,3 Muscarinic Receptor Expression in Rats Fed with Short‐Term/Long‐Term High‐Fat Diets

Changes of Bladder M1,3 Muscarinic Receptor Expression in Rats Fed with Short‐Term/Long‐Term High‐Fat Diets

Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome

Contact Info

Product

Resources

About

Changes of Bladder M_1,3 Muscarinic Receptor Expression in Rats Fed with Short‐Term/Long‐Term High‐Fat Diets

Changes of Bladder M_1,3 Muscarinic Receptor Expression in Rats Fed with Short‐Term/Long‐Term High‐Fat Diets