Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells

Arora, Shagun; Tandon, Simran

doi:10.1007/s13562-015-0309-7

Cited by 4 publications

(1 citation statement)

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“…A survey of 1000 plants for their pharmacological and therapeutic properties in 2010 revealed that wheatgrass has pharmacological significance (Cravotto et al, 2010). In previous literature, wheatgrass was shown to have anti-aging, antioxidant, healing and blood-clotting properties (Singh et al, 2012); an aqueous extract of wheatgrass was even shown to have anti-cancer properties (Arora and Tandon, 2016). Wheatgrass is becoming one of the most widely used health foods.…”

Section: Introductionmentioning

confidence: 99%

Differences in the metabolite profiles of tender leaves of wheat, barley, rye andTriticalebased on LC-MS

Xing

Song

2020

Preprint

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Wheatgrass has emerged as a functional food source in recent years, but the detailed metabolomics basis for its health benefits remains poorly understood. In this study, liquid chromatography-mass spectrometry (LC-MS) analysis were used to study the metabolic profiling of seedlings from wheat, barley, rye and triticale, which revealed 1800 features in positive mode and 4303 features in negative mode. Principal component analysis (PCA) showed clear differences between species, and 164 differentially expressed metabolites (DEMs) were detected, including amino acids, organic acids, lipids, fatty acids, nucleic acids, flavonoids, amines, polyamines, vitamins, sugar derivatives and others. Unique metabolites in each species were identified. This study provides a glimpse into the metabolomics profiles of wheat and its wild relatives, which may form an important basis for nutrition, health and other parameters.Practical ApplicationThis manuscript present liquid chromatography-mass spectrometry (LC-MS) results of young sprouts of common wheat and its relatives. Our results may help to better understand the natural variation due to the genotype before metabolomics data are considered for application to wheatgrass and can provide a basis (assessment) for its potential pharmaceutical and nutritional value.

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Section: Introductionmentioning

confidence: 99%

Differences in the metabolite profiles of tender leaves of wheat, barley, rye andTriticalebased on LC-MS

Xing

Song

2020

Preprint

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Chitosan‐based self‐healing hydrogel mediated by poly(acrylic‐methacrylic acid) exhibiting high biocompatibility and anti‐tumor activity

Pal,

Kumar,

Yadav

et al. 2024

J of Applied Polymer Sci

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Multi‐responsive, self‐healing hydrogels were developed utilizing positively charged polysaccharides, chitosan, and water‐soluble chitosan. This fabrication employed free‐radical synthesized polyacrylic acid and polymethacrylic acid along with the cross‐linker FeCl3, resulting in the generation of polyelectrolyte metal complexes, which enhances the properties of the chitosan‐based hydrogels, particularly their mechanical strength, self‐healing ability, thermal stability, swelling behavior, porous structure, cell viability, and even anticancer activity. Characterization and stability assessment of the hydrogels were performed using FT‐IR, nuclear magnetic resonance, gel permeation chromatography, scanning electron microscopy, rheometer, x‐ray diffraction, thermogravimetric analysis, DSC, and UV spectroscopy. FT‐IR measurements indicated that the facile complexation of the cross‐linker's metal ions (Fe3+) with the carboxylate (COO−), amino (NH), and hydroxyl (OH) groups of the polymers and chitosan chains facilitated rapid gelation. Furthermore, the sustained release of the drug levofloxacin (up to 80%) was observed to increase with increasing pH due to the hydrogels' anionic nature. Biocompatibility and cytotoxicity tests were conducted using the MTT assay on splenocytes and Dalton Lymphoma cancer cell lines. These tests demonstrated the promising potential of these hydrogels for drug delivery applications.

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Folate-targeted nanostructured chitosan/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cells

Soe

Poudel

Nguyen

et al. 2019

Asian Journal of Pharmaceutical Sciences

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Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells

Cited by 4 publications

References 20 publications

Differences in the metabolite profiles of tender leaves of wheat, barley, rye andTriticalebased on LC-MS

Differences in the metabolite profiles of tender leaves of wheat, barley, rye andTriticalebased on LC-MS

Chitosan‐based self‐healing hydrogel mediated by poly(acrylic‐methacrylic acid) exhibiting high biocompatibility and anti‐tumor activity

Folate-targeted nanostructured chitosan/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cells

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