“…13 Mitochondrial permeability transition (MPT) is a key event that occurs in most forms of cell demise (apoptotic, necrotic, autophagic or mitotic), determining the life and death of cells. [14][15][16] The opening of MPT pores causes an abrupt increase of inner mitochondrial membrane permeability to solutes with molecular masses of o1500 Da, 14,16,17 leading to mitochondrial swelling, disruption of the mitochondrial outer membranes and mitochondrial dysfunction. 14-16 Keywords: mitochondria; ASIC1a; MPT; oxidative cell death Abbreviations: Aldh7a1, aldehyde dehydrogenase 7 family member a1; AMI, amiloride; ANT, adenine nucleotide translocase; ASIC1a, acid-sensing ion channel 1a; [Ca 2 þ ] em , extramitochondrial Ca 2 þ concentrations; CRC, Ca 2 þ retention capacity; CsA, cyclosporin A; CTB, Cell-Titer Blue; CypD, cyclophilin D; Cyt C, cytochrome c; DNP, dinitrophenol; DC m , mitochondrial membrane potential; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; Gpd2, glycerol-3-phosphate dehydrogenase 2; Hibch, 3-hydroxyisobutyryl-CoA hydrolase; H 2 O 2 , hydrogen peroxide; MCU, mitochondrial Ca 2 þ uniporter; Mito-DsRed, mitochondrion-targeting red fluorescent protein; MPT, mitochondrial permeability transition; mtASIC1a, mitochondrial ASIC1a; MTCO2, cytochrome c oxidase subunit 2; Mterfd2, mitochondria transcription termination factor domain containing 2; PcTX1, psalmotoxin 1; PDI, protein disulfide isomerase; PI, propidium iodide; Pick1, protein interacting with protein kinase C 1; PIN1peptidylprolyl cis/trans isomerase NIMA-interacting 1; ROS, reactive oxygen species; Slc25a25, solute carrier family 25 member 25; TMRM, tetramethylrhodamine methylester; VDAC, voltage-dependent anion channel…”