Mitochondrial Permeability Transition in Stem Cells, Development, and Disease

Dumbali, Sandeep P; Wenzel, Pamela L.

doi:10.1007/5584_2022_720

Cited by 2 publications

(1 citation statement)

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“…Reductions in OPA1 are therefore likely to negatively affect mitochondrial network activity and potential apoptotic activity [184]. Interestingly, at the same time as the potential reductions in OPA1 and CS, there were potent increases noted in SDHA (succinate dehydrogenase complex subunit A), PPIF (peptidyl-prolyl cis-trans isomerase F), and TOMM20 (translocase of the outer mitochondrial membrane 20), all factors that could positively influence mitochondrial functionality [185][186][187]. Thus, it is likely that at differential expression levels, GPR19 can positively or negatively affect mitochondrial activity-this reinforces the importance of employing subtle in cellula experiments (such as ours described here) to investigate the multidimensional signaling activity of GPCRs.…”

Section: Discussionmentioning

confidence: 99%

GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process

Maudsley

Schrauwen

Harputluoğlu

et al. 2023

IJMS

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G protein-coupled receptors (GPCRs) play a significant role in controlling biological paradigms such as aging and aging-related disease. We have previously identified receptor signaling systems that are specifically associated with controlling molecular pathologies associated with the aging process. Here, we have identified a pseudo-orphan GPCR, G protein-coupled receptor 19 (GPR19), that is sensitive to many molecular aspects of the aging process. Through an in-depth molecular investigation process that involved proteomic, molecular biological, and advanced informatic experimentation, this study found that the functionality of GPR19 is specifically linked to sensory, protective, and remedial signaling systems associated with aging-related pathology. This study suggests that the activity of this receptor may play a role in mitigating the effects of aging-related pathology by promoting protective and remedial signaling systems. GPR19 expression variation demonstrates variability in the molecular activity in this larger process. At low expression levels in HEK293 cells, GPR19 expression regulates signaling paradigms linked with stress responses and metabolic responses to these. At higher expression levels, GPR19 expression co-regulates systems involved in sensing and repairing DNA damage, while at the highest levels of GPR19 expression, a functional link to processes of cellular senescence is seen. In this manner, GPR19 may function as a coordinator of aging-associated metabolic dysfunction, stress response, DNA integrity management, and eventual senescence.

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