Mitochondrial reactive oxygen species are involved in chemoattractant-induced oxidative burst and degranulation of human neutrophils in vitro

Vorobjeva, N.V.; Prikhodko, Anastasia S.; Galkin, Ivan I.; Pletjushkina, Olga Yu.; Zinovkin, Roman A.; Sud’ina, Galina F.; Chernyak, Boris V.; Пинегин, Б В

doi:10.1016/j.ejcb.2017.03.003

Cited by 95 publications

(94 citation statements)

References 63 publications

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“…An important aspect of neutrophil activation is the suppression of spontaneous apoptosis, which is otherwise characteristic of these cells. It was revealed in our studies that neutralization of mtROS with SkQ1 enhances spontaneous apoptosis and cancels the antiapoptotic effect of fMLP, a classical neutrophil activator (Vorobjeva et al, 2017). The main mechanisms that counteracts neutrophil apoptosis depend on the transcription factor NF-κB, which controls the expression of anti-apoptotic proteins of the Bcl-2 family (François et al, 2005).…”

Section: Mtros Are Involved In the Regulation Of Innate Immune Respmentioning

confidence: 77%

“…Recently, extensive research and development projects concerning mitochondria‐targeted drugs have been carried out (Antonenko, Avetisyan, et al, ; Antonenko, Roginsky, et al, ; Lood et al, ; Vorobjeva et al, ). Inhibition of mtROS production or their neutralization by means of mitochondria‐targeted antioxidants is considered as a high‐priority project.…”

Section: Activators Of Mtros Formationmentioning

confidence: 99%

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The role of mitochondrial ROS in antibacterial immunity

Пинегин

Vorobjeva

Pashenkov

et al. 2017

Journal Cellular Physiology

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Reactive oxygen species (ROS) are essential participants of various innate immune cell responses against microorganisms and are also involved in many cellular regulatory pathways. It was believed that the main pool of ROS in the innate immune cells is generated by the NADPH oxidase enzymatic complex. However, it was discovered recently that mitochondrial ROS (mtROS) are equally important for the functioning of the immune system. mtROS play an important role in the development of the antimicrobial innate immune responses. The present mini-review summarizes the most recent data on the role of mtROS in the antibacterial immunity. The principles of mtROS formation and possible mechanisms of their generation under the activation of innate immunity are highlighted in this review. We also speculate on the possibilities of using activators of mtROS production in clinical practice.

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Section: Mtros Are Involved In the Regulation Of Innate Immune Respmentioning

confidence: 77%

Section: Activators Of Mtros Formationmentioning

confidence: 99%

The role of mitochondrial ROS in antibacterial immunity

Пинегин

Vorobjeva

Pashenkov

et al. 2017

Journal Cellular Physiology

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“…) . Furthermore, other studies have now suggested active networks of mitochondria are present in circulating neutrophils and are required for responses such as chemotaxis, through release of low‐level cell signaling ROS . Although disruption of mitochondrial function was not shown to affect respiratory burst or phagocytosis initially, prolonged disruption of mitochondrial membrane potential inhibited respiratory burst, suggesting a steady state role for mitochondrial metabolism in neutrophils .…”

Section: Functional Diversity In Phagocytic Cellsmentioning

confidence: 97%

Diversity and environmental adaptation of phagocytic cell metabolism

Rice

McVicar

Weiss

2018

Journal of Leukocyte Biology

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Phagocytes are cells of the immune system that play important roles in phagocytosis, respiratory burst and degranulation-key components of innate immunity and response to infection. This diverse group of cells includes monocytes, macrophages, dendritic cells, neutrophils, eosinophils, and basophils-heterogeneous cell populations possessing cell and tissue-specific functions of which cellular metabolism comprises a critical underpinning. Core functions of phagocytic cells are diverse and sensitive to alterations in environmental- and tissue-specific nutrients and growth factors. As phagocytic cells adapt to these extracellular cues, cellular processes are altered and may contribute to pathogenesis. The considerable degree of functional heterogeneity among monocyte, neutrophil, and other phagocytic cell populations necessitates diverse metabolism. As we review our current understanding of metabolism in phagocytic cells, gaps are focused on to highlight the need for additional studies that hopefully enable improved cell-based strategies for counteracting cancer and other diseases.

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“…Correspondingly, the mitochondria of activated neutrophils exhibit a remarkable decline in the capacity to produce ATP and instead seem to play a more important role in mediating cell death . Furthermore, in neutrophils, similar to macrophages, the mitochondria also play an important role in ROS production . Treatment of neutrophils with SkQ1, a mitochondria‐targeted antioxidant, attenuated the respiratory burst in neutrophils.…”

Section: Does Altered Mitochondrial Function Represent Pathology or Amentioning

confidence: 75%

How Does Inflammation‐Induced Hyperglycemia Cause Mitochondrial Dysfunction in Immune Cells?

et al. 2019

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Inflammatory mediators have an established role in inducing insulin resistance and promoting hyperglycemia. In turn, hyperglycemia has been argued to drive immune cell dysfunction as a result of mitochondrial dysfunction. Here, the authors review the evidence challenging this view. First, it is pointed out that inflammatory mediators are known to induce altered mitochondrial function. In this regard, critical care patients suffer both an elevated inflammatory tone as well as hyperglycemia, rendering it difficult to distinguish between the effects of inflammation and hyperglycemia. Second, emerging evidence indicates that a decrease in mitochondrial respiration and an increase in reactive oxygen species (ROS) production are not necessarily manifestations of pathology, but adaptations taking shape as the mitochondria is abdicating its adenosine triphosphate (ATP)‐producing function (which is taken over by glycolysis) and instead becomes “retooled” for an immunological role. Collectively, these observations challenge the commonly held belief that acute hyperglycemia induces mitochondrial damage leading to immune cell dysfunction.

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Mitochondrial reactive oxygen species are involved in chemoattractant-induced oxidative burst and degranulation of human neutrophils in vitro

Cited by 95 publications

References 63 publications

The role of mitochondrial ROS in antibacterial immunity

The role of mitochondrial ROS in antibacterial immunity

Diversity and environmental adaptation of phagocytic cell metabolism

How Does Inflammation‐Induced Hyperglycemia Cause Mitochondrial Dysfunction in Immune Cells?

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