Mitochondrial redox biology and homeostasis in plants

Noctor, Graham; Paepe, Rosine De; Foyer, Christine H.

doi:10.1016/j.tplants.2007.01.005

Cited by 458 publications

(321 citation statements)

References 103 publications

Supporting

Mentioning

303

Contrasting

Unclassified

Order By: Relevance

“…Lower capacity of complex I-deficient mutant cells to reoxidize cellular NADH must limit the rate of catabolic pathways (Krebs cycle, glycolysis and acetate assimilation). In photosynthetic organisms, reducing equivalents generated by photosynthetic electron transfer chain can in part be consumed by the mitochondrial respiratory chain, owing to metabolic exchanges between the two organelles (reviewed in Cardol et al, 2011;Noctor et al, 2007). This process can be mediated by the activity of the malate-aspartate shuttle (Noguchi and Yoshida, 2008), whose genes are present in Chlamydomonas (Merchant et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Inactivation of genes coding for mitochondrial Nd7 and Nd9 complex I subunits in Chlamydomonas reinhardtii. Impact of complex I loss on respiration and energetic metabolism

et al. 2014

View full text Add to dashboard Cite

In Chlamydomonas, unlike in flowering plants, genes coding for Nd7 (NAD7/49 kDa) and Nd9 (NAD9/30 kDa) core subunits of mitochondrial respiratory-chain complex I are nucleus-encoded.Both genes possess all the features that facilitate their expression and proper import of the polypeptides in mitochondria. By inactivating their expression by RNA interference or insertional mutagenesis, we show that both subunits are required for complex I assembly and activity.Inactivation of complex I impairs the cell growth rate, reduces the respiratory rate, leads to lower intracellular ROS production and lower expression of ROS scavenging enzymes, and is associated to a diminished capacity to concentrate CO 2 without compromising photosynthetic capacity.

show abstract

Section: Discussionmentioning

confidence: 99%

Inactivation of genes coding for mitochondrial Nd7 and Nd9 complex I subunits in Chlamydomonas reinhardtii. Impact of complex I loss on respiration and energetic metabolism

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Inhibition of Complex I by inhibitors, such as rotenone, or by loss of subunits as in the mutants described above leads to problems with primary metabolism in the affected plants (reviewed in Noctor et al, 2007). The primary entry point for electrons into the electron transport chain is missing, leading to a loss in ATP synthesis and an initial buildup of unoxidized NADH.…”

Section: The Effects Of a Loss Of Complex I Activitymentioning

confidence: 99%

“…Deficiency in Complex I function has been associated with various human diseases, including neurodegenerative diseases, and the aging process (Adam-Vizi and Chinopoulos, 2006;Janssen et al, 2006). In plants, this complex is still the major entry point under normal conditions, even though the electron transport chain is potentially more complicated due to the presence of alternative NAD(P)H dehydrogenases and alternative oxidase (reviewed in Noctor et al, 2007). Due to these alternative pathways, the plant mitochondrial respiratory chain has been a popular target for biochemical studies.…”

Section: Introductionmentioning

confidence: 99%

The Pentatricopeptide Repeat GeneOTP43Is Required fortrans-Splicing of the Mitochondrialnad1Intron 1 inArabidopsis thaliana

et al. 2007

View full text Add to dashboard Cite

The mitochondrial NADH:ubiquinone oxidoreductase complex (Complex I) is a large protein complex formed from both nuclearly and mitochondrially encoded subunits. Subunit ND1 is encoded by a mitochondrial gene comprising five exons, and the mature transcript requires four RNA splicing events, two of which involve trans-splicing independently transcribed RNAs. We have identified a nuclear gene (OTP43) absolutely required for trans-splicing of intron 1 (and only intron 1) of Arabidopsis thaliana nad1 transcripts. This gene encodes a previously uncharacterized pentatricopeptide repeat protein.Mutant Arabidopsis plants with a disrupted OTP43 gene do not present detectable mitochondrial Complex I activity and show severe defects in seed development, germination, and to a lesser extent in plant growth. The alternative respiratory pathway involving alternative oxidase is significantly induced in the mutant.

show abstract

“…Thirdly, the available evidence suggests that the many kinetic constraints on metabolic carbon flow are exquisitely coordinated (Raghavendra & Padmasree 2003;Noctor, De Paepe & Foyer 2006;Rasmusson & Escobar 2007). Any effective model of respiration should at least attempt to capture this coordination.…”

Section: Some Thoughts On the Nature Of Our Modelmentioning

confidence: 99%

“…This could be done from the bottom up, by explicitly describing the many regulatory 'throttles' available to plant cells -for example, control of mitochondrial electron transport and reactions of glycolysis by adenylates, negative feedback inhibition of mitochondrial NAD(P)H dehydrogenases by NADH, redox regulation of alternative oxidase, and inactivation of pyruvate decarboxylase in the light by phosphorylation. We refer readers to the several excellent reviews and textbooks on the subject (Buchanan et al 2000;Atkin & Tjoelker 2003;Noctor et al 2006;Plaxton & Podesta 2006;Rasmusson & Escobar 2007;Lambers et al 2008). Our model captures this coordination from the top down, by applying a single synthetic hypothesis, rather than by attempting to describe this vast array of regulatory processes.…”

Section: Some Thoughts On the Nature Of Our Modelmentioning

confidence: 99%

An analytical model of non‐photorespiratory CO₂ release in the light and dark in leaves of C₃ species based on stoichiometric flux balance

Buckley

Adams

2010

Plant Cell & Environment

View full text Add to dashboard Cite

Leaf respiration continues in the light but at a reduced rate. This inhibition is highly variable, and the mechanisms are poorly known, partly due to the lack of a formal model that can generate testable hypotheses. We derived an analytical model for non-photorespiratory CO2 release by solving steady-state supply/demand equations for ATP, NADH and NADPH, coupled to a widely used photosynthesis model. We used this model to evaluate causes for suppression of respiration by light. The model agrees with many observations, including highly variable suppression at saturating light, greater suppression in mature leaves, reduced assimilatory quotient (ratio of net CO2 and O2 exchange) concurrent with nitrate reduction and a Kok effect (discrete change in quantum yield at low light). The model predicts engagement of non-phosphorylating pathways at moderate to high light, or concurrent with processes that yield ATP and NADH, such as fatty acid or terpenoid synthesis. Suppression of respiration is governed largely by photosynthetic adenylate balance, although photorespiratory NADH may contribute at sub-saturating light. Key questions include the precise diel variation of anabolism and the ATP : 2e -ratio for photophosphorylation. Our model can focus experimental research and is a step towards a fully process-based model of CO2 exchange.Key-words: alternative oxidase; carbon metabolism; Kok effect; photorespiration; photosynthesis; respiration.Abbreviations: A, net CO2 assimilation rate; Ao, net O2 evolution rate; AOX, alternative oxidase; Bn, net anabolic NADH supply; Bp, net anabolic NADPH demand; Bt, net anabolic ATP demand; ci, intercellular CO2 partial pressure; COX, cytochrome oxidase; fm, fraction of photorespiratory NADH that remains in mitochondria; fx, fraction of excess thylakoid reducing potential dissipated as NADPH export; G6PDH, glucose-6-phosphate dehydrogenase; I, incident PPFD; J, potential thylakoid e -transport rate; J′, Vc in RuBP-limiting conditions; Ja, actual thylakoid e -transport rate; Jm, max potential thylakoid e -transport rate; M, maintenance ATP demand; mETC, mitochondrial e -transport chain; O, ambient O2 partial pressure; OPPP, oxidative pentose phosphate pathway; pe, ATP : 2e -ratio, ADP phosphorylated per 2 e -transported to ferredoxin; po, P : O ratio, ratio of ADP phosphorylation to O2 reduction in mitochondria; pom, overall max P : O ratio; pom,ana, max P : O ratio for NADH generated in anabolic C flow; pom,cat, max P : O ratio for NADH derived from catabolic substrate oxidation; pom,cyt, max P : O ratio for cytosol derived NADH; pom,mtx, max P : O ratio for matrix derived NADH; PPFD, photosynthetic photon flux density; QY, quantum yield of CO2 from incident PPFD; Rc, rate of non-photorespiratory CO2 release; Ro, rate of O2 reduction by mitochondria; RuBP, ribulose-1,5-bisphosphate; S, net conversion of TP to sucrose and/or starch; t, net ATP demand resulting from S; TP, triose phosphate; Vana, rate of C flow into C skeletons for biosynthesis; Vby, rate of CO2 release due to ana...

show abstract

Mitochondrial redox biology and homeostasis in plants

Cited by 458 publications

References 103 publications

Inactivation of genes coding for mitochondrial Nd7 and Nd9 complex I subunits in Chlamydomonas reinhardtii. Impact of complex I loss on respiration and energetic metabolism

Inactivation of genes coding for mitochondrial Nd7 and Nd9 complex I subunits in Chlamydomonas reinhardtii. Impact of complex I loss on respiration and energetic metabolism

The Pentatricopeptide Repeat GeneOTP43Is Required fortrans-Splicing of the Mitochondrialnad1Intron 1 inArabidopsis thaliana

An analytical model of non‐photorespiratory CO₂ release in the light and dark in leaves of C₃ species based on stoichiometric flux balance

Contact Info

Product

Resources

About

Mitochondrial redox biology and homeostasis in plants

Cited by 458 publications

References 103 publications

Inactivation of genes coding for mitochondrial Nd7 and Nd9 complex I subunits in Chlamydomonas reinhardtii. Impact of complex I loss on respiration and energetic metabolism

Inactivation of genes coding for mitochondrial Nd7 and Nd9 complex I subunits in Chlamydomonas reinhardtii. Impact of complex I loss on respiration and energetic metabolism

The Pentatricopeptide Repeat GeneOTP43Is Required fortrans-Splicing of the Mitochondrialnad1Intron 1 inArabidopsis thaliana

An analytical model of non‐photorespiratory CO2 release in the light and dark in leaves of C3 species based on stoichiometric flux balance

Contact Info

Product

Resources

About

An analytical model of non‐photorespiratory CO₂ release in the light and dark in leaves of C₃ species based on stoichiometric flux balance