Mitochondrial respiratory capacity remains stable despite a comprehensive and sustained increase in insulin sensitivity in obese patients undergoing gastric bypass surgery

Lund, Marie; Larsen, Steen; Hansen, Melissa Voigt; Courraud, Julie; Floyd, Andrea Karen; Støckel, Mikael; Helge, Jørn Wulff; Dela, Flemming

doi:10.1111/apha.13032

Cited by 19 publications

(15 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of note, we found similar mitochondrial respiratory capacities (normalized to CS) in the healthy control subjects and the patients with type 2 diabetes (Figure ). The patients with type 2 diabetes were clearly insulin‐resistant (Figures and ; Table ), supporting the notion that there is a disassociation between insulin resistance and mitochondrial respiratory function as previously found in skeletal muscle, adipose tissue and hepatic tissue …”

Section: Discussionsupporting

confidence: 85%

Effects of one‐legged high‐intensity interval training on insulin‐mediated skeletal muscle glucose homeostasis in patients with type 2 diabetes

et al. 2019

Self Cite

View full text Add to dashboard Cite

Aim To examine the effect of high‐intensity interval training (HIIT) on glucose clearance rates in skeletal muscle and explore the mechanism within the muscle. Methods Ten males with type 2 diabetes mellitus (T2DM) and ten matched healthy subjects performed 2 weeks of one‐legged HIIT (total of eight sessions, each comprised of 10 × 1 minute ergometer bicycle exercise at >80% of maximal heart rate, interspersed with one min of rest). Insulin sensitivity was assessed by an isoglycaemic, hyperinsulinaemic clamp combined with arteriovenous leg balance technique of the trained (T) and the untrained (UT) leg and muscle biopsies of both legs. Results Insulin‐stimulated glucose clearance in T legs was ~30% higher compared with UT legs in both groups due to increased blood flow in T vs UT legs and maintained glucose extraction. With each training session, muscle glycogen content decreased only in the training leg, and after the training, glycogen synthase and citrate synthase activities were higher in T vs UT legs. No major changes occurred in the expression of proteins in the insulin signalling cascade. Mitochondrial respiratory capacity was similar in T2DM and healthy subjects, and unchanged by HIIT. Conclusion HIIT improves skeletal muscle insulin sensitivity. With HIIT, the skeletal muscle of patients with T2DM becomes just as insulin sensitive as untrained muscle in healthy subjects. The mechanism includes oscillations in muscle glycogen stores and a maintained ability to extract glucose from the blood in the face of increased blood flow in the trained leg.

show abstract

Section: Discussionsupporting

confidence: 85%

Effects of one‐legged high‐intensity interval training on insulin‐mediated skeletal muscle glucose homeostasis in patients with type 2 diabetes

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…A number of articles addressing basic mechanisms related to obesity have recently appeared in Acta physiologica. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] One area of clinical relevance for obese patients is the immune system. Duan et al 20 recapitulate the connections between a high-fat diet and diseases.…”

mentioning

confidence: 99%

“…Although findings on white adipose tissue oxygenation in humans with obesity are conflicting, in a group of 26 obese patients Lund et al did show that gastric bypass surgery-induced weight loss did provoke corresponding changes in mitochondrial respiratory capacity and increase in insulin sensitivity. 11 Recently Makrecka-Kuka et al summarized mitochondrial dysfunction in association with altered metabolic function in the diabetic heart. 13 Glucagon and insulin are two major hormones balancing glucose utilization, production, and its uptake from blood into adipose as well as muscle tissue.…”

mentioning

confidence: 99%

Adipose tissue—more than just fat

Groeneveld

2020

Acta Physiologica

View full text Add to dashboard Cite

“…Growing insulin resistance in obesity often leads to diabetes type 2 and metabolic syndrome. The underlying mechanism of obesity‐induced skeletal muscle insulin resistance is still unclear, but there is growing evidence that mitochondria dynamics are involved during this process and insulin resistance may reflect mitochondrial defects . Kristensen et al propose a hypothetical model of the cellular processes.…”

mentioning

confidence: 99%