Mitochondrial respiratory states and rates

Frostner, Aasander; Karim, Abdul; Na, Abumrad; Rc, Adiele; Ss, Ali; Mg, Alves; Nd, Amoedo; As, Armand; Vf, Avram; Dm, Bailey; Bm, Bakker; Sant'Anna, Bastos; Silva, AC; Da, Beard; Bello, Bednarczyk P; Rk, Berge; Df, Blindheim; Nt, Boardman; Da, Brown; Dt, Cannon; Sanchez, Maria Consolación Cano; Ac, Canto; Lhd, Cardoso; Pinna, Casado; Cb, Haas; Wh, Han; Cr, Hancock; Ip, Hargreaves; Harper, Mary‐Ellen; Dk, Harrison; Hausenloy, Derek J.; Sjr, Heales; Kt, Hellgren; Rt, Hepple; Aj, Hickey; Dh, Ho; Kl, Hoehn; Oj, Holland; Gp, Holloway; Cl, Hoppel; Huete-Ortega, Houstek J; -Gonzalez, Iglesias; Ba, Irving; Cb, Jackson; Pf, Jana; Dh, Jang; Jang, Yeongseon; Nr, Jespersen; Jha, Rajiv Kumar; Mj, Jurczak; Jj, Kaczor; Kampa, Rafał Paweł; Sm, Kandel; Da, Kane; Ma, Keller; Av, Khamoui; Kilbaugh, Kidere D; Hk, Kim; Jks, Kim; Wjh, Kopitar-Jerala N Koopman; Kowaltowski, Alicia J.; Av, Kozlov; Jakovljevic, Krako; Bs, Kristal; Jr, Krycer; Hb, Kwak; Labieniec-Watala, Laasmaa M; Land, Lai N; Ts, Larsen; Gg, Lavery; Lee, Hyun Kyung; Li, J; Li, P A; Lc, López; Macedo, M. Paula; La, Macmillan-Crow; Makrecka-Kuka, Makarova E; An, Malik; Martin, Daniel; Te, Maseko; Jp, Mazat; Ht, Mckenna; Ma, Menze; At, Meszaros; Dr, Moellering

doi:10.26124/mitofit:190001.v2

2019

DOI: 10.26124/mitofit:190001.v2

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Mitochondrial respiratory states and rates

Aasander Frostner¹,

Abdul Karim²,

Abumrad Na³

et al.

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2020

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Adaptation of Mitochondrial Substrate Flux in a Mouse Model of Nonalcoholic Fatty Liver Disease

Staňková

Kučera

Peterová

et al. 2020

IJMS

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Maladaptation of mitochondrial oxidative flux seems to be a considerable feature of nonalcoholic fatty liver disease (NAFLD). The aim of this work was to induce NAFLD in mice fed a Western-style diet (WD) and to evaluate liver mitochondrial functions. Experiments were performed on male C57BL/6J mice fed with a control diet or a WD for 24 weeks. Histological changes in liver and adipose tissue as well as hepatic expression of fibrotic and inflammatory genes and proteins were evaluated. The mitochondrial respiration was assessed by high-resolution respirometry. Oxidative stress was evaluated by measuring lipoperoxidation, glutathione, and reactive oxygen species level. Feeding mice a WD induced adipose tissue inflammation and massive liver steatosis accompanied by mild inflammation and fibrosis. We found decreased succinate-activated mitochondrial respiration and decreased succinate dehydrogenase (SDH) activity in the mice fed a WD. The oxidative flux with other substrates was not affected. We observed increased ketogenic capacity, but no impact on the capacity for fatty acid oxidation. We did not confirm the presence of oxidative stress. Mitochondria in this stage of the disease are adapted to increased substrate flux. However, inhibition of SDH can lead to the accumulation of succinate, an important signaling molecule associated with inflammation, fibrosis, and carcinogenesis.

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Adaptation of Mitochondrial Substrate Flux in a Mouse Model of Nonalcoholic Fatty Liver Disease

Staňková

Kučera

Peterová

et al. 2020

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

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Mitochondrial respiratory states and rates

Cited by 1 publication

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Adaptation of Mitochondrial Substrate Flux in a Mouse Model of Nonalcoholic Fatty Liver Disease

Adaptation of Mitochondrial Substrate Flux in a Mouse Model of Nonalcoholic Fatty Liver Disease

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