2004
DOI: 10.1016/s1097-2765(04)00179-0
|View full text |Cite
|
Sign up to set email alerts
|

Mitochondrial Signaling

Abstract: Mitochondrial retrograde signaling is a pathway of communication from mitochondria to the nucleus that influences many cellular and organismal activities under both normal and pathophysiological conditions. In yeast it is used as a sensor of mitochondrial dysfunction that initiates readjustments of carbohydrate and nitrogen metabolism. In both yeast and animal cells, retrograde signaling is linked to TOR signaling, but the precise connections are unclear. In mammalian cells, mitochondrial dysfunction sets off … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

4
395
0

Year Published

2004
2004
2024
2024

Publication Types

Select...
7
2
1

Relationship

0
10

Authors

Journals

citations
Cited by 792 publications
(399 citation statements)
references
References 112 publications
4
395
0
Order By: Relevance
“…2 C and D). That inhibition may reflect that a nuclear-encoded splicing factor for these introns is downregulated in the respiration-deficient strain (21).…”
Section: Mss116p Is Required For Efficient Splicing Of All S Cerevismentioning
confidence: 99%
“…2 C and D). That inhibition may reflect that a nuclear-encoded splicing factor for these introns is downregulated in the respiration-deficient strain (21).…”
Section: Mss116p Is Required For Efficient Splicing Of All S Cerevismentioning
confidence: 99%
“…Finally, deletion of this domain has been shown to favor translocation of Bax to the mitochondrial membrane in yeast (Priault et al, 2003). Since all the other proteins tested can be located in the mitochondrial membrane, it is tempting to speculate that overexpression of Bcl-2 family members affects mitochondria membranes resulting in mitochondrial signaling reminiscent of the 'retrograde response' (Butow and Avadhani, 2004), affecting in fine HR. In line with this, depletion of mitochondrial DNA compromises the respiratory chain function, affects the mitochondrial membrane and results in mutagenesis of nuclear DNA (Delsite et al, 2003).…”
Section: Inhibition Of Homologous Recombination By Bax or Bidmentioning
confidence: 99%
“…Mitochondria themselves can elicit intracellular signaling pathways that alter nuclear gene expression, mitochondria number, and function (5,6). This signaling process is referred to as retrograde signaling.…”
mentioning
confidence: 99%