Mitochondrial-targeting and NIR-responsive Mn3O4@PDA@Pd-SS31 nanozymes reduce oxidative stress and reverse mitochondrial dysfunction to alleviate osteoarthritis

Li, Yuquan; Yang, Junxu; Chen, Xiaoming; Hu, Hao; Lan, Nihan; Zhao, Jinmin; Zheng, Li

doi:10.1016/j.biomaterials.2023.122449

Cited by 14 publications

(4 citation statements)

References 70 publications

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“…Mitochondria are the main organelles in cells that produce ROS, and scavenging ROS is a viable treatment for OA. 2 Because excessive ROS causes mitochondrial dysfunction and disrupts homeostasis in CHO cells, leading to changes in membrane potential (Δ ψ m ) and abnormal calcium regulation. These dysfunctions, in turn, further induce a “vicious cycle” of ROS and promote the development of OA.…”

Section: Resultsmentioning

confidence: 99%

“…Osteoarthritis (OA) is globally known to be a highly prevalent degenerative disease of cartilage and is recognized by the medical community as one of today's major public health problems. 1,2 According to preliminary statistics, more than 250 million people worldwide suffer from this disease each year and end up with up to ∼41% disability. 2,3 A recent study reported that with the rapid growth of the aging population, nearly 25% of adults are expected to have OA by 2030.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 According to preliminary statistics, more than 250 million people worldwide suffer from this disease each year and end up with up to ∼41% disability. 2,3 A recent study reported that with the rapid growth of the aging population, nearly 25% of adults are expected to have OA by 2030. 4 Despite the high prevalence and disability caused by OA, there is a lack of effective methods to target the management of this widespread disease.…”

Section: Introductionmentioning

confidence: 99%

“…6 Recently, scavenging the ROS generated by oxidative stress in chondrocytes (CHOs) has been recognized as the most promising approach for the treatment of OA. 2,7–10 However, the biggest bottleneck in clinical practice is how to achieve sustained and efficient ROS removal, reducing damage to CHOs to rebuild cartilage structure and function.…”

Section: Introductionmentioning

confidence: 99%

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Nano-enzyme hydrogels for cartilage repair effectiveness based on ternary strategy therapy

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Wan

et al. 2024

J. Mater. Chem. B

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nano-enzyme hydrogels for cartilage repair effectiveness based on ternary strategy therapy

Deng,

Zhou,

Wan

et al. 2024

J. Mater. Chem. B

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Mimicomes: Mimicking Multienzyme System by Artificial Design

Cao,

Jiang,

Chen

et al. 2024

Adv Healthcare Materials

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Enzymes are widely distributed in organelles of cells, which are capable of carrying out specific catalytic reactions. In general, several enzymes collaborate to facilitate complex reactions and engage in vital biochemical processes within cells, which are also called cascade systems. The cascade systems are highly efficient, and their dysfunction is associated with a multitude of endogenous diseases. The advent of nanotechnology makes it possible to mimic these cascade systems in nature and realize partial functions of natural biological processes both in vitro and in vivo. To emphasize the significance of artificial cascade systems, mimicomes is first proposed, a new concept that refers to the artificial cascade catalytic systems. Typically, mimicomes are able to mimic specific natural biochemical catalytic processes or facilitate the overall catalytic efficiency of cascade systems. Subsequently, the evolution and development of different types of mimicomes in recent decades are elucidated exhaustedly, from the natural enzyme‐based mimicomes (immobilized enzyme and vesicle mimicomes) to the nanozyme‐based mimicomes and enzyme‐nanozyme hybrid mimicomes. In conclusion, the remaining challenges in the design of multifunctional mimicomes and their potential applications are summarized, offering insights into their future prospects.

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Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for Osteoradionecrosis Therapy

Cheng,

Wang,

Lin

et al. 2024

Advanced Science

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Four to eight percent of patients with head and neck cancer will develop osteoradionecrosis of the jaw (ORNJ) after radiotherapy. Various radiation‐induced tissue injuries are associated with reactive oxygen and nitrogen species (RONS) overproduction. Herein, Fe doping is used in VOx (Fe‐VOx) nanozymes with multienzyme activities for ORNJ treatment via RONS scavenging. Fe doping can induce structure reconstruction of nanozymes with abundant defect production, including Fe substitution and oxygen vacancies (OVs), which markedly increased multiple enzyme‐mimicking activity. Catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) enzyme‐like performance of Fe‐VOx can effectively reprogram jawbone microenvironment to restore mitochondrial dysfunction and enhance mitophagy. Moreover, the surface plasmon resonance (SPR) effect of Fe‐VOx made it a good photothermal nanoagents for inhibiting jaw infection. Thus, this work demonstrated that Fe‐VOx nanozymes can efficiently scavenge RONS, activate mitophagy, and inhibit bacteria, which is potential for ORNJ treatment.

show abstract

Mitochondrial-targeting and NIR-responsive Mn3O4@PDA@Pd-SS31 nanozymes reduce oxidative stress and reverse mitochondrial dysfunction to alleviate osteoarthritis

Cited by 14 publications

References 70 publications

Nano-enzyme hydrogels for cartilage repair effectiveness based on ternary strategy therapy

Nano-enzyme hydrogels for cartilage repair effectiveness based on ternary strategy therapy

Mimicomes: Mimicking Multienzyme System by Artificial Design

Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for Osteoradionecrosis Therapy

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