Mitochondrial toxicity of triclosan on mammalian cells

Ajao, Charmaine; Andersson, Maria A.; Теплова, В. В.; Nagy, Szabolcs; Gahmberg, Carl G.; Andersson, Leif C.; Hautaniemi, Maria; Kakasi, Balázs; Roivainen, Merja; Salkinoja‐Salonen, Mirja

doi:10.1016/j.toxrep.2015.03.012

Cited by 91 publications

(56 citation statements)

References 87 publications

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“…This topic was recently reviewed by Ruszkiewicz et al (2017). Briefly, TCS was found to affect mitochondrial function (Weatherly et al 2016; Shim et al 2016; Newton et al 2005; Ajao et al 2015), disrupt proper calcium signaling (Cherednichenko et al 2012), alter zinc homeostasis (Tamura et al 2012), and affect immunological parameters (Anderson et al 2013; Yueh et al 2014; Udoji et al 2010; Weatherly et al 2013). …”

Section: Triclosan-mediated Adverse Health Effectsmentioning

confidence: 99%

“…As previously indicated, several studies showed that TCS exhibited endocrine disrupting effects, which may account for a portion of the adverse reproductive outcomes observed in the epidemiological studies. Mitochondrial disruption by antimicrobial (Weatherly et al 2016; Ajao et al 2015; Newton et al 2005) may also contribute to adverse reproductive effects as proper mitochondrial function is required for embryonic development (Chen et al 2003). …”

Section: Triclosan-mediated Adverse Health Effectsmentioning

confidence: 99%

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Triclosan exposure, transformation, and human health effects

Weatherly

Gosse

2017

Journal of Toxicology and Environmental Health, Part B

429

236

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Triclosan (TCS) is an antimicrobial used so ubiquitously that 75% of the U.S.A. population is likely exposed to this compound via consumer goods and personal care products. In September 2016, TCS was banned from soap products following the risk assessment by the U.S.A. Food and Drug Administration (FDA). However, TCS still remains, at high concentrations, in other personal care products such as toothpaste, mouthwash, hand sanitizer, and surgical soaps. Triclosan is readily absorbed into human skin and oral mucosa and found in various human tissues and fluids. The aim of this review was to describe TCS exposure routes and levels as well as metabolism and transformation processes. The burgeoning literature on human health effects associated with TCS exposure, such as reproductive problems was also summarized.

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Section: Triclosan-mediated Adverse Health Effectsmentioning

confidence: 99%

Section: Triclosan-mediated Adverse Health Effectsmentioning

confidence: 99%

Triclosan exposure, transformation, and human health effects

Weatherly

Gosse

2017

Journal of Toxicology and Environmental Health, Part B

429

236

View full text Add to dashboard Cite

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“…Thus while membrane proteins account for only ~ 30% of the human proteome [9, 10], they play an outsized role in controlling biological processes by regulating the transit of matter and information across the membrane. Indeed, dysregulation of membrane crossing events can have profound effects leading to disease [11, 12] or even death [13, 14]. …”

Section: Membrane Activity Is a Critical Factor In The Biology Of Smamentioning

confidence: 99%

The cellular membrane as a mediator for small molecule interaction with membrane proteins

Mayne

Arcario

Mahinthichaichan

et al. 2016

Biochimica et Biophysica Acta (BBA) - Biomembranes

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The cellular membrane constitutes the first element that encounters a wide variety of molecular species to which a cell might be exposed. Hosting a large number of structurally and functionally diverse proteins associated with this key metabolic compartment, the membrane not only directly controls the traffic of various molecules in and out of the cell, it also participates in such diverse and important processes as signal transduction and chemical processing of incoming molecular species. In this article, we present a number of cases where details of interaction of small molecular species such as drugs with the membrane, which are often experimentally inaccessible, have been studied using advanced molecular simulation techniques. We have selected systems in which partitioning of the small molecule with the membrane constitutes a key step for its final biological function, often binding to and interacting with a protein associated with the membrane. These examples demonstrate that membrane partitioning is not only important for the overall distribution of drugs and other small molecules into different compartments of the body, it may also play a key role in determining the efficiency and the mode of interaction of the drug with its target protein.

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“…Its toxic nature has been proved in several studies conducted on water organisms and also on human cells [9]. The EC50 value of TCS calculated using the Microtox ® test received 0.08 mg/L.…”

Section: Resultsmentioning

confidence: 97%

Toxicological analysis of water mixtures of organic micropollutants subjected to UV irradiation

Kudlek

2018

E3S Web Conf.

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Abstract. The paper presents the toxicological analysis of water solutions of micropollutants from different groups i.e. industrial additives, pharmaceutical compounds, hormones, UV blockers and pesticides before and after their exposure to UV light. The toxicological response of both Microtox ® and Daphtoxkit F ® test, increased with the increase of the compound concentration. Triclosan water solution was considered as the most toxic. The lowest toxic effect was observed for Imidacloprid and Octyl-methoxycinnamate solutions. The exposure of Benzocaine, Octyl-methoxycinnamate and Triclosan water solutions to UV light led to an increase of their toxicity. An inverse relationship was observed for Imidacloprid and 17α-Ethinylestradiol solutions.

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Mitochondrial toxicity of triclosan on mammalian cells

Cited by 91 publications

References 87 publications

Triclosan exposure, transformation, and human health effects

Triclosan exposure, transformation, and human health effects

The cellular membrane as a mediator for small molecule interaction with membrane proteins

Toxicological analysis of water mixtures of organic micropollutants subjected to UV irradiation

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