Mitoferrin-2-dependent Mitochondrial Iron Uptake Sensitizes Human Head and Neck Squamous Carcinoma Cells to Photodynamic Therapy

Hung, Hsin-I; Schwartz, Justin; Maldonado, Eduardo N.; Lemasters, John J.; Nieminen, Anna‐Liisa

doi:10.1074/jbc.m112.422667

Cited by 57 publications

(60 citation statements)

References 35 publications

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“…On the other hand, it has been reported that BAF treatment promotes the release of lysosomal iron in hepatocytes (66). Moreover, such a mechanism has been attributed to the fact that BAF is capable of enhancing the cytotoxicity of phthalocyanine 4-PDT (photodynamic therapy) in A431 cancer cells and in human head and neck squamous carcinoma cells via increased mitochondrial iron uptake (67,68). In our study, we found that BAF decreases intracellular iron level, indicated by the increase of the IRP2 protein level (Fig.…”

Section: Discussionmentioning

confidence: 99%

Artesunate Induces Cell Death in Human Cancer Cells via Enhancing Lysosomal Function and Lysosomal Degradation of Ferritin

Yang

Tan

et al. 2014

Journal of Biological Chemistry

142

110

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Background: Artesunate is capable of inducing cell death in cancer cells. Results: Artesunate accumulates in lysosomes and promotes lysosomal function and ferritin degradation, leading to mitochondrial reactive oxygen species production and eventually cell death. Conclusion: Intracellular iron and ferritin degradation is essential for artesunate-induced lysosomal activation and cell death. Significance: This work reveals a novel mechanism underlying artesunate-induced cell death.

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Section: Discussionmentioning

confidence: 99%

Artesunate Induces Cell Death in Human Cancer Cells via Enhancing Lysosomal Function and Lysosomal Degradation of Ferritin

Yang

Tan

et al. 2014

Journal of Biological Chemistry

142

110

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“…Indeed, blockade of MCU with Ru360 attenuated mitochondrial dysfunction caused by iron overload [58]. However, the specific mechanisms involved in this process require further elucidation.…”

Section: Mitochondrial Iron Metabolismmentioning

confidence: 99%

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

Lane

Merlot

Huang

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

319

255

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Iron is a crucial transition metal for virtually all life. Two major destinations of iron within mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In mitochondria, iron is utilized in critical anabolic pathways, including: iron-storage in mitochondrial ferritin, heme synthesis, and iron-sulfur cluster (ISC) biogenesis. Although the pathways involved in ISC synthesis in the mitochondria and cytosol have begun to be characterized, many crucial details remain unknown. In this review, we discuss major aspects of the journey of iron from its initial cellular uptake, its modes of trafficking within cells, to an overview of its downstream utilization in the cytoplasm and within mitochondria. The understanding of mitochondrial iron processing and its communication with other organelles/subcellular locations, such as the cytosol, has been elucidated by the analysis of certain diseases e.g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease.

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“…Knockdown of MFRN2 decreases mitochondrial iron uptake in human epithelial cell lines (Hung et al, 2013) and its depletion in cultivated mouse fibroblasts reduced heme synthesis and mitochondrial Fe/S cluster assembly . A similar effect was seen upon depletion of MFRN1, indicating that both Mfrn1 and Mfrn2 contribute to mitochondrial iron acquisition in non-erythroid mammalian cells .…”

Section: The Mitochondrial Inner Membrane Transportersmentioning

confidence: 99%

Compartmentalization of iron between mitochondria and the cytosol and its regulation

Mühlenhoff

Hoffmann

Richter

et al. 2015

European Journal of Cell Biology

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Mitoferrin-2-dependent Mitochondrial Iron Uptake Sensitizes Human Head and Neck Squamous Carcinoma Cells to Photodynamic Therapy

Cited by 57 publications

References 35 publications

Artesunate Induces Cell Death in Human Cancer Cells via Enhancing Lysosomal Function and Lysosomal Degradation of Ferritin

Artesunate Induces Cell Death in Human Cancer Cells via Enhancing Lysosomal Function and Lysosomal Degradation of Ferritin

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

Compartmentalization of iron between mitochondria and the cytosol and its regulation

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