Mitogen-activated protein kinase cascades in signaling plant growth and development

Xu, Juan; Zhang, Shuqun

doi:10.1016/j.tplants.2014.10.001

Cited by 461 publications

(379 citation statements)

References 97 publications

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“…The main reason for this may be the multifunctional nature of MPK6, which plays essential roles in plant stress responses, growth, and development (Nakagami et al, 2005;Xing et al, 2008Xing et al, , 2009Schikora et al, 2011;Dutilleul et al, 2012;Xu and Zhang, 2015). Actually, MPK6 is a common target among several MAPK cascades Meng et al, 2012;Smékalová et al, 2014).…”

Section: Mkk5-mpk6 Are the Downstream Targets Of Aik1 In Aba Signalingmentioning

confidence: 99%

“…A MAPK cascade is minimally composed of MAP kinase kinase kinases (MAPKKKs/MEKKs/MKKKs), MAP kinase kinases (MAPKKs/MEKs/MKKs), and MAP kinases (MAPKs/MPKs), which sequentially phosphorylate the corresponding downstream substrates (Tena et al, 2001;Ichimura et al, 2002;Mishra et al, 2006;Rodriguez et al, 2010;Xu and Zhang, 2015). Sequence and functional analyses of the Arabidopsis genome have revealed that there are 20 MAPKs, 10 MAPKKs, and 80 MAPKKKs, with a similar repertoire of genes observed in other plant genomes (Ichimura et al, 2002;Hamel et al, 2006;Colcombet and Hirt, 2008).…”

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confidence: 99%

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AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade

et al. 2016

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The mitogen-activated protein kinase (MAPK) cascade is an evolutionarily conserved signal transduction module involved in transducing extracellular signals to the nucleus for appropriate cellular adjustment. This cascade essentially consists of three components: a MAPK kinase kinase (MAPKKK), a MAPK kinase, and a MAPK, connected to each other by the event of phosphorylation. Here, we report the characterization of a MAPKKK, ABA-INSENSITIVE PROTEIN KINASE1 (AIK1), which regulates abscisic acid (ABA) responses in Arabidopsis (Arabidopsis thaliana). T-DNA insertion mutants of AIK1 showed insensitivity to ABA in terms of both root growth and stomatal response. AIK1 functions in ABA responses via regulation of root cell division and elongation, as well as stomatal responses. The activity of AIK1 is induced by ABA in Arabidopsis and tobacco (Nicotiana benthamiana), and the Arabidopsis protein phosphatase type 2C, ABI1, a negative regulator of ABA signaling, restricts AIK1 activity by dephosphorylation. Bimolecular fluorescence complementation analysis showed that MPK3, MPK6, and AIK1 interact with MKK5. The single mutant seedlings of mpk6 and mkk5 have similar phenotypes to aik1, but mkk4 does not. AIK1 was localized in the cytoplasm and shown to activate MKK5 by protein phosphorylation, which was an ABA-activated process. Constitutively active MKK5 in aik1 mutant seedlings complements the ABA-insensitive root growth phenotype of aik1. The activity of MPK6 was increased by ABA in wild-type seedlings, but its activation by ABA was impaired in aik1 and aik1 mkk5 mutants. These findings clearly suggest that the AIK1-MKK5-MPK6 cascade functions in the ABA regulation of primary root growth and stomatal response.

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Section: Mkk5-mpk6 Are the Downstream Targets Of Aik1 In Aba Signalingmentioning

confidence: 99%

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confidence: 99%

AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade

et al. 2016

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“…Consistently, the MAPK-insensitive mutant version of SPCH no longer responds to osmotic stress (Kumari et al, 2014). Other studies have further emphasized the role for MAPK cascades as a signaling hub (Meng and Zhang, 2013;Tena et al, 2011;Xu and Zhang, 2015).…”

Section: Signal Integration During Stomatal Developmentmentioning

confidence: 70%

Lineage-specific stem cells, signals and asymmetries during stomatal development

Han

Torii

2016

Development

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Stomata are dispersed pores found in the epidermis of land plants that facilitate gas exchange for photosynthesis while minimizing water loss. Stomata are formed from progenitor cells, which execute a series of differentiation events and stereotypical cell divisions. The sequential activation of master regulatory basic-helix-loop-helix (bHLH) transcription factors controls the initiation, proliferation and differentiation of stomatal cells. Cell-cell communication mediated by secreted peptides, receptor kinases, and downstream mitogenactivated kinase cascades enforces proper stomatal patterning, and an intrinsic polarity mechanism ensures asymmetric cell divisions. As we review here, recent studies have provided insights into the intrinsic and extrinsic factors that control stomatal development. These findings have also highlighted striking similarities between plants and animals with regards to their mechanisms of specialized cell differentiation.

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“…However, in many cases, the sensing of a signal does not result in a single cascade of events (Sasidharan & Mustroph, 2011; Ikeuchi et al , 2017; Wang et al , 2017), but in the activation of different pathways that are connected to each other at various levels. A well‐known example is the convergence of different pathways at several MAPKs (Xu & Zhang, 2015; Chardin et al , 2017). Instead of multiple parallel linear pathways, networks are a more correct view.…”

Section: Discussionmentioning

confidence: 99%

From network to phenotype: the dynamic wiring of an Arabidopsis transcriptional network induced by osmotic stress

Broeck

Dubois

Vermeersch

et al. 2017

Molecular Systems Biology

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Plants have established different mechanisms to cope with environmental fluctuations and accordingly fine‐tune their growth and development through the regulation of complex molecular networks. It is largely unknown how the network architectures change and what the key regulators in stress responses and plant growth are. Here, we investigated a complex, highly interconnected network of 20 Arabidopsis transcription factors (TFs) at the basis of leaf growth inhibition upon mild osmotic stress. We tracked the dynamic behavior of the stress‐responsive TFs over time, showing the rapid induction following stress treatment, specifically in growing leaves. The connections between the TFs were uncovered using inducible overexpression lines and were validated with transient expression assays. This study resulted in the identification of a core network, composed of ERF6, ERF8, ERF9, ERF59, and ERF98, which is responsible for most transcriptional connections. The analyses highlight the biological function of this core network in environmental adaptation and its redundancy. Finally, a phenotypic analysis of loss‐of‐function and gain‐of‐function lines of the transcription factors established multiple connections between the stress‐responsive network and leaf growth.

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Mitogen-activated protein kinase cascades in signaling plant growth and development

Cited by 461 publications

References 97 publications

AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade

AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade

Lineage-specific stem cells, signals and asymmetries during stomatal development

From network to phenotype: the dynamic wiring of an Arabidopsis transcriptional network induced by osmotic stress

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