2016
DOI: 10.1128/jvi.01407-16
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Mitogen-Activated Protein Kinase Kinase 2, a Novel E2-Interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway

Abstract: The mitogen-activated protein kinase kinase/extracellular regulated kinase (MEK1/2/ERK1/2) cascade is involved in the replication of several members of the Flaviviridae family, including hepatitis C virus and dengue virus. The effects of the cascade on the replication of classical swine fever virus (CSFV), a fatal pestivirus of pigs, remain unknown. In this study, MEK2 was identified as a novel binding partner of the E2 protein of CSFV using yeast two-hybrid screening. The E2-MEK2 interaction was confirmed by … Show more

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Cited by 23 publications
(17 citation statements)
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References 44 publications
(47 reference statements)
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“…Eukaryotic elongation factor 1A binds to CSFV replicase protein NS5A to block virus replication ( Li et al, 2015 ). Mitogen-activated protein kinase 2 interacts with CSFV main antigen protein E2 to promote CSFV growth via the attenuation of the JAK-STAT signaling pathway ( Hu et al, 2016 ; Wang et al, 2016 ). Rab5 interacts with tomato bushy stunt virus replication protein to support virus replication and protects the virus from host antiviral responses ( Xu and Nagy, 2016 ).…”
Section: Discussionmentioning
confidence: 99%
“…Eukaryotic elongation factor 1A binds to CSFV replicase protein NS5A to block virus replication ( Li et al, 2015 ). Mitogen-activated protein kinase 2 interacts with CSFV main antigen protein E2 to promote CSFV growth via the attenuation of the JAK-STAT signaling pathway ( Hu et al, 2016 ; Wang et al, 2016 ). Rab5 interacts with tomato bushy stunt virus replication protein to support virus replication and protects the virus from host antiviral responses ( Xu and Nagy, 2016 ).…”
Section: Discussionmentioning
confidence: 99%
“…E rns has been demonstrated to interact with the laminin receptor [16]. In addition, E2 has been shown to interact with several host proteins including cellular actin [17], thioredoxin [18], annexin 2 [19], mitogen-activated protein kinase 2 [20], protein phosphatase 1 catalytic subunit beta [21] and dynactin 6 [22]. These host-virus protein-protein interactions have been shown to play a role in regulating the virus replication cycle, and in some cases, these protein interactions are involved in virus virulence [12][13][14]22].…”
Section: Introductionmentioning
confidence: 99%
“…This suggests that genetic variants 372A/G and 496G/A (protein variants 124Ile/Met and 166Gly/Ser) in NS5 of dENV-1 condition the degree of antagonism with type 1 interferon due to interruption of JAK-STAT1. It has recently been reported, in similar viruses, that replication increases through inhibiting the JAK-STAT signaling pathway (34).…”
Section: Discussionmentioning
confidence: 99%