Mitogen‐activated protein kinase signaling is involved in nonylphenol‐induced proinflammatory cytokines secretion by BV2 microglia

Gu, Weijia; Wang, Yi; Qiu, Zhenmin; Dong, Jing; Wang, Yuan; Chen, Jie

doi:10.1002/jat.3602

Cited by 10 publications

(4 citation statements)

References 55 publications

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“…In Table 1 , the MIC values of essential oil and streptomycin sulfate are much lower than that of MgONPs. However, streptomycin sulfate has been recognized to aggregate in the human body through the food chain and cause risks ( Gu et al, 2018 ). The EC 50 values of chloramphenicol and bismerthiazol was 20 and 59.69 μg/mL, respectively.…”

Section: Resultsmentioning

confidence: 99%

Magnesium Oxide Nanoparticles: Effective Agricultural Antibacterial Agent Against Ralstonia solanacearum

et al. 2018

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Magnesium (Mg) is an essential mineral element for plants and is nontoxic to organisms. In this study, we took advantage of nanotechnologies to systematically investigate the antibacterial mechanisms of magnesium oxide nanoparticles (MgONPs) against the phytopathogen Ralstonia solanacearum (R. solanacearum) in vitro and in vivo for the first time. R. solanacearum has contributed to catastrophic bacterial wilt, which has resulted in the world-wide reduction of tobacco production. The results demonstrated that MgONPs possessed statistically significant concentration-dependent antibacterial activity, and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were measured as 200 and 250 μg/mL, respectively. Additional studies, aimed at understanding the toxicity mechanism of MgONPs, indicated that physical injury occurred to the cell membranes, along with decreased motility and biofilm formation ability of R. solanacearum, due to the direct attachment of MgONPs to the surfaces of the bacterial cells, which was observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Reactive oxygen species (ROS) accumulation could also be an important reason for the antibacterial action, inducing DNA damage. The toxicity assessment assay under greenhouse conditions demonstrated that the MgONPs had exerted a large effect on tobacco bacterial wilt, reducing the bacterial wilt index. Altogether, the results suggest that the development of MgONPs as alternative antibacterial agents will become a new research subject.

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Section: Resultsmentioning

confidence: 99%

Magnesium Oxide Nanoparticles: Effective Agricultural Antibacterial Agent Against Ralstonia solanacearum

et al. 2018

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“…The BV2 microglial cells were used here to study the underlying mechanisms of QDs causing microglial activation, as they were recently commonly used in in vitro biological models to explore neuroinflammation promoted by NPs (Gu et al, ). According to the results from our previous metabolomics analysis, there was a change in glycometabolism that oxidative phosphorylation shifted to aerobic glycolysis in CdTe@ZnS QD‐activated BV2 cells, which was observed in this study by the increased glycolysis level and glycolysis ability as well as the decreased ATP production.…”

Section: Discussionmentioning

confidence: 99%

The glycolytic shift was involved in CdTe/ZnS quantum dots inducing microglial activation mediated through the mTOR signaling pathway

et al. 2019

J of Applied Toxicology

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The excellent optical property and relatively low toxicity of CdTe/ZnS core/shell quantum dots (QDs) make them an advanced fluorescent probe in the application of biomedicines, particularly in neuroscience. Thus, it is important to evaluate the biosafety of CdTe/ZnS QDs on the central nervous system (CNS). Our previous studies have suggested that the high possibility of CdTe/ZnS QDs being transported into the brain across the blood‐brain barrier resulted in microglial activation and a shift of glycometabolism, but their underlying mechanism remains unclear. In this study, when mice were injected intravenously with CdTe/ZnS QDs through tail veins, the microglial activation, polarized into both M1 phenotype and M2 phenotype, and the neuronal impairment were observed in the hippocampus. Meanwhile, the increased pro‐ and anti‐inflammatory cytokines released from BV2 microglial cells treated with CdTe/ZnS QDs also indicated that QD exposure was capable of inducing microglial activation in vitro. We further demonstrated that the glycolytic shift from oxidative phosphorylation switching into aerobic glycolysis was required in the microglial activation into M1 phenotype induced by CdTe/ZnS QD treatment, which was mediated through the mTOR signaling pathway. The findings, taken together, provide a mechanistic insight regarding the CdTe/ZnS QDs inducing microglial activation and the role of the glycolytic shift in it.

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“…Similarly, two separate studies found that NP induces apoptosis in murine neural stem cells, neuronally differentiated PC12 cells, and the mouse brain due to the activation/up-regulation of caspases, the suppression of BCL-2 transcription, and an increased intracellular Ca 2+ concentration [ 57 , 61 ]. Apparently, another way to induce apoptosis by NP is to increase the expression of the JNK gene [ 62 ]. JNK belongs to the superfamily of MAP kinases and plays an important role in regulating cell proliferation, differentiation, and intrinsic mitochondrial apoptotic pathways.…”

Section: Apoptosis Signalingmentioning

confidence: 99%

The Investigation into Neurotoxicity Mechanisms of Nonylphenol: A Narrative Review

Lotfi

Hasanpour

Moghadamnia

et al. 2021

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Background: Nonylphenol (NP), as a chemical compound that widely used in industry, is the result of the nonylphenol ethoxylate decomposition and it is known as an estrogen-like compound. Numerous studies and researches have shown that it has many destructive functions of various organs such as the brain. This toxicant causes oxidative stress in the cortex and hippocampus cells, which are two essential regions to preserve memory and learning in the brain. Methods: This review examines recent findings to better understand the mechanisms of NP neurotoxicity. We used Scopus, Google Scholar and PubMed databases to find articles with focus on the destructive effects of NP on the oxidative stress pathway and its defense mechanisms. Results: NP has potential human health hazard associated with gestational, peri- and postnatal exposure. NP can disrupt brain homeostasis in different ways, such as activation of inflammatory factors in brain especially in hippocampus and cortex, disruption of the cell cycle, changes in neuron, dendrites and synapses morphology, disruption of extra and intracellular calcium ion balance and also memory and learning disorders

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Mitogen‐activated protein kinase signaling is involved in nonylphenol‐induced proinflammatory cytokines secretion by BV2 microglia

Cited by 10 publications

References 55 publications

Magnesium Oxide Nanoparticles: Effective Agricultural Antibacterial Agent Against Ralstonia solanacearum

Magnesium Oxide Nanoparticles: Effective Agricultural Antibacterial Agent Against Ralstonia solanacearum

The glycolytic shift was involved in CdTe/ZnS quantum dots inducing microglial activation mediated through the mTOR signaling pathway

The Investigation into Neurotoxicity Mechanisms of Nonylphenol: A Narrative Review

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