Mitonuclear Mate Choice: A Missing Component of Sexual Selection Theory?

Hill, Geoffrey E.

doi:10.1002/bies.201700191

Cited by 25 publications

(16 citation statements)

References 123 publications

(213 reference statements)

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“…It has been proposed that the necessity for mitonuclear coadaptation for cellular respiration may underlie a range of core evolutionary innovations and concepts. These include the evolution of sex and two sexes in eukaryotes (Hadjivasiliou et al ., ; Havird, Hall & Dowling, ), the evolution of a sequestered germ line in bilaterian animals (Radzvilavicius et al ., ), climate and resource adaptation (Camus et al ., ; Sunnucks et al ., ), sexual selection (Hill & Johnson, ; Hill, ), and speciation (Dowling et al ., ; Burton & Barreto, ; Hill, ).…”

Section: Implications Of Mitonuclear Interactions Spanning Ecology Anmentioning

confidence: 99%

Assessing the fitness consequences of mitonuclear interactions in natural populations

et al. 2018

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Complex life exists only with a continuous and rich supply of energy from oxidative phosphorylation in mitochondria. The biochemical machinery that enables the majority of energy production in eukaryotes is encoded by both mitochondrial and nuclear genes so the products of these genomes must interact closely to achieve coordinated function of core respiratory processes. It follows that selection for efficient respiration will lead to selection on optimal combinations of mitochondrial and nuclear genotypes, facilitating mitonuclear coadaptation. In this essay, we outline the modes by which mitochondrial and nuclear genomes coevolve within natural populations, and discuss the implications of mitonuclear coadaptation for diverse fields of study in the biological sciences. We identify six themes in the study of mitonuclear interactions, developed through decades of research, which provide a roadmap for both ecological and biomedical studies seeking to elucidate the contribution of intergenomic coevolution to the genetics of natural populations.

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Section: Implications Of Mitonuclear Interactions Spanning Ecology Anmentioning

confidence: 99%

Assessing the fitness consequences of mitonuclear interactions in natural populations

et al. 2018

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“…Increased maintenance costs, characterized by elevated BMR, in females compared to males in the line selected for male dominance (Figure 1), suggests linkage between male fitness and female energetics (Hayward & Gillooly, 2011;Watson, Arnqvist, & Stallmann, 1998), or more specifically, genetic mito-nuclear incompatibility between the sexes (Hill, 2018;Rand et al, 2001). As the inheritance of mitochondria, the "energetic factories" of the cells, in mammals is mostly via females, selection on a male's energetic performance might be ineffective.…”

Section: Discussionmentioning

confidence: 99%

Maintenance costs of male dominance and sexually antagonistic selection in the wild

et al. 2018

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Variation in dominance status determines male mating and reproductive success, but natural selection for male dominance can be detrimental or antagonistic for female performance, and ultimately their fitness. Attaining and maintaining a high dominance status in a population of competing individuals is physiologically costly for males. But how male dominance status is mediated by maintenance energetics is currently not well understood, nor are the corresponding effects of male energetics on his sisters recognized. We conducted laboratory and field experiments on rodent populations to test whether selective breeding for male dominance status (dominant vs. subordinate breeding lines) antagonistically affected basal metabolic rate (BMR) and fitness of females under wild conditions. Our results showed elevated BMR in females, but not in males, from the dominant breeding line. However, phenotypically dominant males from the subordinate breeding line had the highest BMR. Males from the dominant line with low BMR sired the most litters and offspring in the field. Similarly, females from the dominant selection line tended to have more offspring if they had lower BMR, while the opposite trend was found in females from the subordinate selection line. Females with high and low BMR reproduced most often, as indicated by a significant quadratic selection gradient. The increased female BMR resulting from selection for male dominance suggests genetic incompatibility between sexes in metabolism inheritance. Elevated BMR in behaviourally dominant males, but not in males from the dominant breeding line, suggests physiological costs in males not genetically suited for dominance. Fitness costs of elevated maintenance costs (measured as BMR) shown here support the energetic compensation hypothesis where high BMR is selected against as it would trade off energy required for other important life‐history attributes. A http://onlinelibrary.wiley.com/doi/10.1111/1365-2435.13216/suppinfo is available for this article.

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“…[ 105–106 ] A good match between nuclear and mitochondrial genes may be required for optimal functioning of enzymes of the electron transport chain. [ 107–109 ] The mechanisms by which the female mitochondria recognize the foreignness of invading paternal mitochondria remains obscure. [ 106 ] Maintenance of mitophagy as an essential feature of mammalian reproduction may shed light on why certain prokaryotic organisms (resembling foreign mitochondria) may induce inflammatory reactions in the host.…”

Section: Mitochondrial Function That Ensures Human Reproductive Fitnementioning

confidence: 99%

Evolutionary Views of Tuberculosis: Indoleamine 2,3‐Dioxygenase Catalyzed Nicotinamide Synthesis Reflects Shifts in Macrophage Metabolism

et al. 2020

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Indoleamine 2,3-dioxygenase (IDO) is the rate-limiting enzyme in conversion of tryptophan to kynurenines, feeding de novo nicotinamide synthesis. IDO orchestrates materno-foetal tolerance, increasing human reproductive fitness. IDO mediates immune suppression through depletion of tryptophan required by T lymphocytes and other mechanisms. IDO is expressed by alternatively activated macrophages, suspected to play a key role in tuberculosis (TB) pathogenesis. Unlike its human host, Mycobacterium tuberculosis can synthesize tryptophan, suggesting possible benefit to the host from infection with the microbe. Intriguingly, nicotinamide analogues are used to treat TB. In reviewing this field, it is postulated that flux through the nicotinamide synthesis pathway reflects switching between aerobic glycolysis and oxidative phosphorylation in M. tuberculosis-infected macrophages. The evolutionary cause of such shifts may be ancient mitochondrial behavior related to reproductive fitness. Evolutionary perspectives on the IDO pathway may elucidate why, after centuries of co-existence with the Tubercle bacillus, humans still remain susceptible to TB disease.

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Mitonuclear Mate Choice: A Missing Component of Sexual Selection Theory?

Cited by 25 publications

References 123 publications

Assessing the fitness consequences of mitonuclear interactions in natural populations

Assessing the fitness consequences of mitonuclear interactions in natural populations

Maintenance costs of male dominance and sexually antagonistic selection in the wild

Evolutionary Views of Tuberculosis: Indoleamine 2,3‐Dioxygenase Catalyzed Nicotinamide Synthesis Reflects Shifts in Macrophage Metabolism

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