Mitophagy and cGAS–STING crosstalk in neuroinflammation

Novel Insights into Parkin–Mediated Mitochondrial Dysfunction and “Mito-Inflammation” in α-Synuclein Toxicity. The Role of the cGAS–STING Signalling Pathway

“… 31 Inappropriate activation of the cGAS–STING triggered by the nuclear DNA, mtDNA, mitochondrial damage and failures in Parkin–mediated mitophagy has been linked to neurodegenerative diseases. 31 , 39 , 40 Aberrant cGAS–STING response contributes to neuroinflammation and promotes degeneration of neuronal cells. 41 In chronic neurodegenerative diseases states, exacerbated cGAS–STING–mediated IFN-I response shapes the glia phenotype and accelerates disease progression.…”