Mitophagy regulation in aging and neurodegenerative disease

Banarase, Trupti A.; Sammeta, Shivkumar S.; Wankhede, Nitu L.; Mangrulkar, Shubhada V.; Rahangdale, Sandip R.; Aglawe, Manish M.; Taksande, Brijesh G.; Upaganlawar, Aman; Umekar, Milind J.; Kale, Mayur B.

doi:10.1007/s12551-023-01057-6

Cited by 12 publications

(3 citation statements)

References 186 publications

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“…Cellular and molecular processes involving mitochondria in AD pathology have been extensively reported in recent years [45][46][47][48]. Despite the extensive literature on this topic, in the following sections, more focus is placed on how mitochondrial processes related to mitochondrial transport, apoptosis, and oxidative phosphorylation for the maintenance of redox homeostasis may be regulated by steroid receptors through tibolone and how the underlying mechanisms are most affected in AD.…”

Section: Mitochondrial Dysfunction In Alzheimer's Pathologymentioning

confidence: 99%

Repurposing of Tibolone in Alzheimer’s Disease

Barreto

2023

Biomolecules

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Alzheimer’s disease (AD) is a debilitating neurodegenerative disease characterised by the accumulation of amyloid-beta and tau in the brain, leading to the progressive loss of memory and cognition. The causes of its pathogenesis are still not fully understood, but some risk factors, such as age, genetics, and hormones, may play a crucial role. Studies show that postmenopausal women have a higher risk of developing AD, possibly due to the decrease in hormone levels, especially oestrogen, which may be directly related to a reduction in the activity of oestrogen receptors, especially beta (ERβ), which favours a more hostile cellular environment, leading to mitochondrial dysfunction, mainly affecting key processes related to transport, metabolism, and oxidative phosphorylation. Given the influence of hormones on biological processes at the mitochondrial level, hormone therapies are of clinical interest to reduce the risk or delay the onset of symptoms associated with AD. One drug with such potential is tibolone, which is used in clinics to treat menopause-related symptoms. It can reduce amyloid burden and have benefits on mitochondrial integrity and dynamics. Many of its protective effects are mediated through steroid receptors and may also be related to neuroglobin, whose elevated levels have been shown to protect against neurological diseases. Its importance has increased exponentially due to its implication in the pathogenesis of AD. In this review, we discuss recent advances in tibolone, focusing on its mitochondrial-protective effects, and highlight how valuable this compound could be as a therapeutic alternative to mitigate the molecular pathways characteristic of AD.

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Section: Mitochondrial Dysfunction In Alzheimer's Pathologymentioning

confidence: 99%

Repurposing of Tibolone in Alzheimer’s Disease

Barreto

2023

Biomolecules

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“…Contributed by a group of pharmaceutical researchers from India, the fifth review article within Issue 2 (Banarase et al 2023) is an interesting examination of both, the general process of mitophagy-the programmed death of damaged mitochondria, and the similarities and differences between mitophagy occurrence in cellular aging, and that occurring in several neurodegenerative diseases (such as Alzheimer's and Parkinson's diseases). Given that large cells, like neurons, can contain ~ millions of mitochondria, it is easy to appreciate how defects in mitophagy can lead to the catastrophic uncoupling of mechanisms required for achieving redox homeostasis (Banarase et al 2023).…”

Section: Precis Of the Current Issuementioning

confidence: 99%

Biophysical Reviews: And the winner is …

Hall

2023

Biophys Rev

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This Editorial (Vol. 15 Issue 2-Regular Issue) first announces the winner of the 2023 Michèle Auger Award for Young Scientists' Independent Research before then going on to describe the contents of the current Issue. The Editorial closes with a discussion of the pros and cons of writing in the formulation of scientific ideas.Each year, the Biophysical Reviews journal runs a single competition known as the "Michèle Auger Award for Young Scientists' Independent Research". Started in 2020, the award carries out two functions that are important to the journal:(i) The annual award acts as a perpetual memorial for a much admired and well-liked former Editorial Board Member Prof. Michèle Auger (IUPAB 2018), (ii) Helps to recognize the next generation of biophysicists by providing a forum to have their work read and appreciated within the scientific community.In this section, I would like to explain some of the benefits available to those nominated for the award, the process by which this year's award was judged, and finally, to announce the winner of this year's award.

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“…Mitophagy is also involved in numerous physiological functions, such as delaying the ageing process and cell differentiation. Interference in these processes induces physiological senescence and several age-related diseases (Krantz et al, 2021;Banarase et al, 2023;Sanz et al, 2023). Recent evidence indicates that impaired mitochondrial energy metabolism and age-related diseases share pathological features, such as an increased mutation rate in mitochondrial DNA (mtDNA), impaired electron transport chain function, elevated ROS levels, and the enhanced release of pro-apoptotic factors (Fang et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Potential application of traditional Chinese medicine in age-related macular degeneration—focusing on mitophagy

Yu,

Wang,

Liu

et al. 2024

Front. Pharmacol.

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Retinal pigment epithelial cell and neuroretinal damage in age-related macular degeneration (AMD) can lead to serious visual impairments and blindness. Studies have shown that mitophagy, a highly specialized cellular degradation system, is implicated in the pathogenesis of AMD. Mitophagy selectively eliminates impaired or non-functioning mitochondria via several pathways, such as the phosphatase and tensin homolog-induced kinase 1/Parkin, BCL2-interacting protein 3 and NIP3-like protein X, FUN14 domain-containing 1, and AMP-activated protein kinase pathways. This has a major impact on the maintenance of mitochondrial homeostasis. Therefore, the regulation of mitophagy could be a promising therapeutic strategy for AMD. Traditional Chinese medicine (TCM) uses natural products that could potentially prevent and treat various diseases, such as AMD. This review aims to summarize recent findings on mitophagy regulation pathways and the latest progress in AMD treatment targeting mitophagy, emphasizing methods involving TCM.

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Mitophagy regulation in aging and neurodegenerative disease

Cited by 12 publications

References 186 publications

Repurposing of Tibolone in Alzheimer’s Disease

Repurposing of Tibolone in Alzheimer’s Disease

Biophysical Reviews: And the winner is …

Potential application of traditional Chinese medicine in age-related macular degeneration—focusing on mitophagy

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