Mitosis, Focus on Calcium

Nugues, Charlotte; Helassa, Nordine; Haynes, Lee P.

doi:10.3389/fphys.2022.951979

Cited by 9 publications

(4 citation statements)

References 95 publications

(113 reference statements)

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“…The enhanced Ca 2+ transfer into the mitochondria in mitosis may affect the spatial dynamics of Ca 2+ signals, which have been historically implicated in mitosis progression. 38 , 39 , 40 For example, localized Ca 2+ transients have been associated with the metaphase-to-anaphase transition, 41 , 42 and have been detected at the centrosomes in mitosis. 43 Ca 2+ signals have also been shown to be dispensable for entry into meiosis but required for the transition of the anaphase.…”

Section: Resultsmentioning

confidence: 99%

Mitochondria-ER contact sites expand during mitosis

Yu,

Courjaret,

Assaf

et al. 2024

iScience

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Section: Resultsmentioning

confidence: 99%

Mitochondria-ER contact sites expand during mitosis

Yu,

Courjaret,

Assaf

et al. 2024

iScience

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“…Jun et al (2019) also demonstrated that loading MTA with cerium nanoparticles promoted a significant increase (90%) in the viability of human dental pulp stem cells (hDPSCs), leading to odontoblastic differentiation [24]. It is well known that calcium ions are important in cellular division processes [54,55]. They play a fundamental role in activating or inhibiting many intracellular reactions that control cell cycles, especially mitosis.…”

Section: Discussionmentioning

confidence: 99%

Effect of Modified Bioceramic Mineral Trioxide Aggregate Cement with Mesoporous Nanoparticles on Human Gingival Fibroblasts

Kalash,

Tsamesidis,

Pouroutzidou

et al. 2024

CIMB

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The ion doping of mesoporous silica nanoparticles (MSNs) has played an important role in revolutionizing several materials applied in medicine and dentistry by enhancing their antibacterial and regenerative properties. Mineral trioxide aggregate (MTA) is a dental material widely used in vital pulp therapies with high success rates. The aim of this study was to investigate the effect of the modification of MTA with cerium (Ce)- or calcium (Ca)-doped MSNs on the biological behavior of human gingival fibroblasts (hGFs). MSNs were synthesized via sol–gel, doped with Ce and Ca ions, and mixed with MTA at three ratios each. Powder specimens were characterized using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Biocompatibility was evaluated using a 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay following hGFs’ incubation in serial dilutions of material eluates. Antioxidant status was evaluated using Cayman’s antioxidant assay after incubating hGFs with material disc specimens, and cell attachment following dehydration fixation was observed through SEM. Material characterization confirmed the presence of mesoporous structures. Biological behavior and antioxidant capacity were enhanced in all cases with a statistically significant increase in CeMTA 50.50. The application of modified MTA with cerium-doped MSNs offers a promising strategy for vital pulp therapies.

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“…Indeed another study looking at neurons, another postmitotic cell, failed to see protection from cadmium-induced cell death when inhibiting the mitochondrial calcium uniporter (Tang et al, 2021). Calcium signaling in general and specifically calmodulin, calcium release via the IP3 receptor, and activation of the mitochondrial uniporter have all been shown to be important for the progression of mitosis (Lagos-Cabré et al, 2020; Nugues et al, 2022; Rasmussen and Means, 1989; Takuwa et al, 1995; Zhao et al, 2019). Therefore, mitotic cells may be more sensitive to cadmium-induced alterations in these calcium signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

The role of calcium, Akt and ERK signaling in cadmium-induced hair cell death

Galdieri¹,

Adams²,

Padilla

et al. 2022

Preprint

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Exposure to heavy metals, an environmental toxin, has been shown to cause damage to a variety of different tissues and cell types including hair cells, the sensory cells of our inner ears responsible for hearing and balance. Elevated levels of one such metal, cadmium, has been associated with hearing loss and shown to cause hair cell death in multiple experimental models. While the mechanisms of cadmium-induced cell death have been extensively studied in other cell types they remain relatively unknown in hair cells. We have found that calcium signaling, known to be an important regulator of cadmium toxicity in other cell types, does not appear to play a significant role in cadmium-induced hair cell death. While calmodulin inhibition can partially protect hair cells this may be due to impacts on mechanotransduction activity, and inhibiting CaMKII, the IP3 receptor and the mitochondrial calcium uniporter all failed to protect against cadmium-induced hair cell death. We also found cadmium treatment increased pAkt levels in hair cells and pERK levels in supporting cells. This activation appears to be protective in nature as inhibiting these pathways enhanced cadmium-induced hair cell death rather than protecting cells. Thus cadmium-induced hair cell death appears distinct from cadmium-induced cell death in other cell types where calcium, Akt and ERK signaling pathways all promote cell death.

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Mitosis, Focus on Calcium

Cited by 9 publications

References 95 publications

Mitochondria-ER contact sites expand during mitosis

Mitochondria-ER contact sites expand during mitosis

Effect of Modified Bioceramic Mineral Trioxide Aggregate Cement with Mesoporous Nanoparticles on Human Gingival Fibroblasts

The role of calcium, Akt and ERK signaling in cadmium-induced hair cell death

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