Mitotic genes are transcriptionally upregulated in the fibroblast irradiated with very low doses of UV-C

Takeuchi, Seiji; Matsuda, Takanori; Ono, Ryusuke; Tsujimoto, Mariko; Nishigori, Chikako

doi:10.1016/j.jdermsci.2017.02.238

Cited by 1 publication

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“…It is reported that UVC radiation-induced DNA damage provoked highly divergent responses in human skin fibroblasts exposed to low (10 J/m 2 ) and high doses (50 J/m 2 ) of UVC radiation [3]. Another report showed that UVC could affect the transcriptional profile in human primary cultured fibroblasts irradiated with even a low dose (0.5 or 5 J/m 2 ) of UVC [4].…”

Section: Introductionmentioning

confidence: 99%

The Potential Regulatory Roles of lncRNAs in DNA Damage Response in Human Lymphocytes Exposed to UVC Irradiation

Wang

et al. 2020

BioMed Research International

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Long noncoding RNAs (lncRNAs) are a class of noncoding RNAs that modulate gene expression, thereby participating in the regulation of various cellular processes. However, it is not clear about the expression and underlying mechanism of lncRNAs in irradiation-induced DNA damage response. In the present study, we performed integrative analysis of lncRNA-mRNA expression profile in human lymphocytes irradiated with ultraviolet-C (UVC). The results showed that exposure to UVC irradiation dose-dependently increased the fluorescence intensity of γ-H 2 AX and induced cell death. Microarray analysis revealed that up-regulated lncRNAs were more common than down-regulated lncRNAs with the increase of radiation dose in UVC-radiated cells. Stem analysis demonstrated the relationship between lncRNA expression level and radiation dose. qPCR results confirmed that LOC338799 and its coexpressed genes such as LCE1F and ISCU showed the increase in expression levels with the increase of UVC radiation dose. We utilized Cytoscape to screen out 5 lncRNAs and 13 coexpressed genes linking to p53, which might participate in the regulation of DNA damage, cell cycle arrest, apoptosis, and cell death. These findings suggest that lncRNAs might play a role in UVC-induced DNA damage response through regulating expression of genes in p53 signaling pathway.

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Section: Introductionmentioning

confidence: 99%

The Potential Regulatory Roles of lncRNAs in DNA Damage Response in Human Lymphocytes Exposed to UVC Irradiation

Wang

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

show abstract

Mitotic genes are transcriptionally upregulated in the fibroblast irradiated with very low doses of UV-C

Cited by 1 publication

References 23 publications

The Potential Regulatory Roles of lncRNAs in DNA Damage Response in Human Lymphocytes Exposed to UVC Irradiation

The Potential Regulatory Roles of lncRNAs in DNA Damage Response in Human Lymphocytes Exposed to UVC Irradiation

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