Mitotic Stimulation of Adrenal Medullary Chromaffin Cells by Oxytocin

Previous study has shown that oxytocin (OT) attenuated the postcastration regression of ventral prostate epithelium in rats. To decide if this effect is associated with stimulation of cell division or improvement of cell survival, metaphase index of secretory cells and frequency of apoptotic bodies in the epithelium, combined with stereological parameters, were determined in the present study. OT was injected subcutaneously in a dose of 0.25 IU/100 g/d during 5 postorchiectomal days and the same treatment was applied to intact rats. Only the prostate of castrated animals responded to OT. They had greater total volume of the epithelium, total number and metaphase index of secretory cells, but lower frequency of apoptotic bodies. These findings demonstrate the ability of OT to stimulate mitotic activity and to diminish mortality of secretory cells caused by orchiectomy.

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Mitotic activity and cell deletion in ventral prostate epithelium of intact and castrated oxytocin-treated rats

Plećaš

Popović

Jovović

et al. 1992

J Endocrinol Invest

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Société Belge de Biochimie; Belgische Vereniging Voor Biochemie

1991

Archives Internationales de Physiologie, de Biochimie et de Bio

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Mitotic Stimulation of Adrenal Medullary Chromaffin Cells by Oxytocin

Cited by 2 publications

References 7 publications

Mitotic activity and cell deletion in ventral prostate epithelium of intact and castrated oxytocin-treated rats

Mitotic activity and cell deletion in ventral prostate epithelium of intact and castrated oxytocin-treated rats

Société Belge de Biochimie; Belgische Vereniging Voor Biochemie

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