Mitotically Active Leiomyomas of the Uterus: About Two Cases

Hilali, Fouzia El; Aalalou, Hayat; Lemine, O.M.; Saoud, Mohamed Karam; Nissrinemamouni, a; Errarhay, Sanaa; Bouchikhi, C.; Banani, Abdelaziz

doi:10.21474/ijar01/12287

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Mitotically active leiomyoma is diagnosed in the pre-menopausal period. Leiomyoma with bizarre nuclei occurs at an average age of 42.5–49.8, 10–15 years earlier than for leiomyosarcoma [ 9 , 10 ]. In the study conducted by Kefeli M et al, the authors included 30 cases of patients aged between 38 and 89 years, with an average of 49.76 years [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Pathogenesis Associated with the Tumor Microclimate in the Differential Diagnosis of Uterine Myocytic Tumors

Boşoteanu

Deacu

Aşchie

et al. 2023

JCM

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Myocytic tumors of the uterus present vast morphological heterogeneity, which makes differential diagnosis between the different entities necessary. This study aims to enrich the existing data and highlight new potential therapeutic targets regarding aspects related to the pathogenic process and the tumor microenvironment in order to improve the quality of life of women. We performed a 5-year retrospective study, including particular cases of uterine myocyte tumors. Immunohistochemical analyses of pathogenic pathways (p53, RB1, and PTEN) and tumor microclimate using markers (CD8, PD-L1, and CD105), as well as genetic testing of the PTEN gene, were performed. The data were statistically analyzed using the appropriate parameters. In cases of atypical leiomyoma, a significant association was observed between PTEN deletion and an increased number of PD-L1+ T lymphocytes. For malignant lesions and STUMP, PTEN deletion was associated with the advanced disease stage. Advanced cases were also associated with an increased mean CD8+ T cell count. An increased number of lymphocytes was associated with an increased percentage of RB1+ nuclei. The study corroborated clinical and histogenetic data, highlighting the importance of the differential diagnosis of these tumors to improve the management of patients and increase their quality of life.

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Section: Discussionmentioning

confidence: 99%

The Role of Pathogenesis Associated with the Tumor Microclimate in the Differential Diagnosis of Uterine Myocytic Tumors

Boşoteanu

Deacu

Aşchie

et al. 2023

JCM

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Clinical case of mitotically active uterine leiomyoma

Zakharov,

Bezmenko,

Solomko

et al. 2024

jour

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One of the rare variants of uterine smooth muscle tumors is mitotically active leiomyoma, histological characteristics of which are defined by a high number of mitoses in the absence of necrosis and cellular atypia. Despite the presence of mitotic activity, this tumor process is benign. Mitotically active leiomyoma of the uterus is usually diagnosed in patients in the perimenopausal period and its size typically does not exceed 10 cm. This article presents a rare clinical case of a giant-sized mitotically active leiomyoma of the uterus in a woman of reproductive age. Attention is drawn to the challenges in clinical diagnosis and the difficulties in differentiation from malignant neoplasms. The primary treatment method for mitotically active leiomyoma of the uterus is surgical (myomectomy or hysterectomy as indicated). According to several publications, no recurrence of this pathology was observed during patient follow-up after surgical treatment ranging from 6 months to 15 years. Considering the clinical and macroscopic similarity of mitotically active leiomyoma with leiomyosarcoma, careful histological verification of the diagnosis is necessary to determine the correct management strategy.

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Mitotically Active Leiomyomas of the Uterus: About Two Cases

Cited by 2 publications

References 5 publications

The Role of Pathogenesis Associated with the Tumor Microclimate in the Differential Diagnosis of Uterine Myocytic Tumors

The Role of Pathogenesis Associated with the Tumor Microclimate in the Differential Diagnosis of Uterine Myocytic Tumors

Clinical case of mitotically active uterine leiomyoma

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