Mitoxantrone treatment in a patient with multiple sclerosis and pattern III lesions

Abstract

Background Brain biopsies of multiple sclerosis patients identified three intraindividually stable lesion patterns. Apart from beneficial effects of plasma exchange in patients with type II lesions, little is known about how multiple sclerosis lesion histology could guide therapeutic decisions. Case presentation Here, we report on a 53‐year‐old male patient with polysymptomatic cerebral syndrome as the first episode of multiple sclerosis. Brain biopsy showed an inflammatory demyelinating lesion with apoptotic oligodendrocytes and a loss of myelin‐associated glycoprotein, pathological features typical for pattern III lesions. High‐dose steroids and immunosuppressive treatment with mitoxantrone led to a substantial improvement of disability and long‐term clinical stability. Conclusion Mitoxantrone therapy along with steroid pulses could potentially be considered as a therapeutic option for pattern III lesions.

Knowledge and awareness on Balo's disease among dental students

“…Another study says that autoimmune factors have a key role in the progression of Balo disease. [ 29 ] Several anatomical, physicochemical, and cytotoxic theories have been suggested, to elucidate the development of the typical lesions in Balo's disease, the latest one is the theory of tissue preconditioning, explained by Stadelmann et al . [ 2 ]…”