MitraClip® as bridging strategy for heart transplantation in Chagas cardiomyopathy: a case report

Vasquez-Rodriguez, Juan F.; Medina, Héctor M.; Cabrales, Jaime; Torres, Adriana Gisella

doi:10.1093/ehjcr/ytz238

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…In selected patients, particularly those with severe pulmonary hypertension due to severe functional mitral regurgitation, a Mitral Clip can be used as a bridge option to decrease the severity of mitral valve dysfunction and ultimately pulmonary pressure to permit enlisting patients for HT [ 157 ].…”

Section: Current Treatment and Prognosismentioning

confidence: 99%

Chagas Cardiomyopathy: From Romaña Sign to Heart Failure and Sudden Cardiac Death

et al. 2021

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Despite nearly a century of research and accounting for the highest disease burden of any parasitic disease in the Western Hemisphere, Chagas disease (CD) is still a challenging diagnosis, primarily due to its poor recognition outside of Latin America. Although initially considered endemic to Central and South America, globalization, urbanization, and increased migration have spread the disease worldwide in the last few years, making it a significant public health threat. The international medical community’s apparent lack of interest in this disease that was previously thought to be geographically restricted has delayed research on the complex host–parasite relationship that determines myocardial involvement and its differential behavior from other forms of cardiomyopathy, particularly regarding treatment strategies. Multiple cellular and molecular mechanisms that contribute to degenerative, inflammatory, and fibrotic myocardial responses have been identified and warrant further research to expand the therapeutic arsenal and impact the high burden attributed to CD. Altogether, cardiac dysautonomia, microvascular disturbances, parasite-mediated myocardial damage, and chronic immune-mediated injury are responsible for the disease’s clinical manifestations, ranging from asymptomatic disease to severe cardiac and gastrointestinal involvement. It is crucial for healthcare workers to better understand CD transmission and disease dynamics, including its behavior on both its acute and chronic phases, to make adequate and evidence-based decisions regarding the disease. This review aims to summarize the most recent information on the epidemiology, pathogenesis, clinical presentation, diagnosis, screening, and treatment of CD, emphasizing on Chagasic cardiomyopathy’s (Ch-CMP) clinical presentation and pathobiological mechanisms leading to sudden cardiac death.

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Section: Current Treatment and Prognosismentioning

confidence: 99%

Chagas Cardiomyopathy: From Romaña Sign to Heart Failure and Sudden Cardiac Death

et al. 2021

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“…Finally, given the high morbidity and mortality of patients with advanced heart failure secondary to CD, advanced interventions should be considered in patients with refractory symptoms. Although very few studies have been conducted, some experimental evidence suggests that the use of mitral clip in Ch-CMP as well as left ventricular assistance devices might prove valuable for the management of end-stage heart failure due to CD [174][175][176]. On the other hand, heart transplantation remains another option for the treatment of advanced Ch-CMP [177][178][179].…”

Section: Clinical Manifestations Diagnosis and Treatmentmentioning

confidence: 99%

Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review

et al. 2021

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Chronic manifestations of Chagas disease present as disabling and life-threatening conditions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mechanisms underlying Trypanosoma cruzi’s infection and the host-parasite interactions that follow, prompt diagnosis and treatment remain a challenge, particularly in developing countries and also in those where the disease is considered non-endemic. This review intends to present an up-to-date review of the parasite’s life cycle, genetic diversity, virulence factors, and infective mechanisms, as well as the epidemiology, clinical presentation, diagnosis, and treatment options of the main chronic complications of Chagas disease.

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MitraClip® as bridging strategy for heart transplantation in Chagas cardiomyopathy: a case report

Cited by 2 publications

References 14 publications

Chagas Cardiomyopathy: From Romaña Sign to Heart Failure and Sudden Cardiac Death

Chagas Cardiomyopathy: From Romaña Sign to Heart Failure and Sudden Cardiac Death

Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review

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