Mitral annular calcification associated with impaired coronary microvascular function

Bozbaş, Hüseyin; Pirat, Bahar; Yildirir, Aylin; Simsek, Vahide; Sade, Leyla Elif; Altın, Cihan; Müderrisoğlu, Haldun

doi:10.1016/j.atherosclerosis.2007.09.044

Cited by 12 publications

(13 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bozbas et al. has showed that MAC is associated with impaired coronary microvascular functions . It has been suggested that development of MAC, like atherosclerosis, may be initiated by endothelial disruption at foci of increased mechanical stress, such as the junction between the mitral valve annulus and ventricular myocardium.…”

Section: Discussionmentioning

confidence: 99%

“…Mitral annular calcification (MAC) is a chronic, degenerative process characterized by calcification of the surrounding fibrous support of the mitral valve . Although the exact mechanism is not well understood, MAC appears to be associated with cardiovascular risk factors and clinical atherosclerosis . However, it has been well established that the presence of MAC is not merely a marker of systemic atherosclerosis.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Association of Mitral Annular Calcification with Left Ventricular Mechanics: A Speckle Tracking Study

Gökdeniz

Boyacı²,

Hatem³

et al. 2014

Echocardiography

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Association of Mitral Annular Calcification with Left Ventricular Mechanics: A Speckle Tracking Study

Gökdeniz

Boyacı²,

Hatem³

et al. 2014

Echocardiography

View full text Add to dashboard Cite

show abstract

“…Mitral annular calcification (MAC) 1 is characterized by calcium and lipid deposition in the annular fibrosa of the mitral valve 2,3 . MAC has been shown to be associated with increased cardiovascular burden such as coronary artery disease, 4 arrhythmias, 5 stroke, 6,7 and death 5 . Because lipid‐rich atherosclerotic plaques in coronary vessels undergo calcification with chronicity, a similar mechanism has been cited to occur with MAC 2,8 .…”

mentioning

confidence: 99%

Is the Presence of Mitral Annular Calcification Associated with Poor Left Atrial Function?

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Coronary calcification has been shown to be predictive of cardiovascular disease mortality; whereas calcification of the carotid arteries, thoracic aorta, and iliac arteries are predictive of total mortality [24]. Calcification of the aortic valve has a strong association with coronary microvascular endothelial dysfunction and overall coronary atherosclerotic plaque burden as well as MAC [7,8,25]. ACS can be the first manifestation of coronary artery atherosclerosis, thus making the identification of plaques at high risk of complication an important component of strategies to reduce casualties.…”

Section: Discussionmentioning

confidence: 99%

Plaque Vulnerability as Assessed by Radiofrequency Intravascular Ultrasound in Patients with Valvular Calcification

et al. 2016

View full text Add to dashboard Cite

BackgroundCardiac valvular calcification is associated with the overall coronary plaque burden and considered an independent cardiovascular risk and prognostic factor. The purpose of this study was to evaluate the relationship between the presence of valvular calcification and plaque morphology and/or vulnerability.MethodsTransthoracic echocardiography was used to assess valvular calcification in 280 patients with coronary artery disease who underwent radiofrequency intravascular ultrasound (Virtual Histology IVUS, VH-IVUS). A propensity score–matched cohort of 192 patients (n = 96 in each group) was analyzed. Thin-capped fibroatheroma (TCFA) was defined as a necrotic core (NC) >10% of the plaque area with a plaque burden >40% and NC in contact with the lumen for ≥3 image slices. A remodeling index (lesion/reference vessel area) >1.05 was considered to be positive.ResultsPatients were divided into two groups: any calcification in at least one valve (152 patients) vs. no detectable valvular calcification (128 patients). Groups were similar in terms of age, risk factors, clinical diagnosis, and angiographic analysis after propensity score-matched analysis. Gray-scale IVUS analysis showed that the vessel size, plaque burden, minimal lumen area, and remodeling index were similar. By VH-IVUS, % NC and % dense calcium (DC) were greater in patients with valvular calcification (p = 0.024, and p = 0.016, respectively). However, only % DC was higher at the maximal NC site by propensity score-matched analysis (p = 0.029). The frequency of VH-TCFA occurrence was higher depending on the complexity (p = 0.0064) and severity (p = 0.013) of valvular calcification.ConclusionsThere is a significant relationship between valvular calcifications and VH-IVUS assessment of TCFAs. Valvular calcification indicates a greater atherosclerosis disease complexity (increased calcification of the coronary plaque) and vulnerable coronary plaques (higher incidence of VH-TCFA).

show abstract

Mitral annular calcification associated with impaired coronary microvascular function

Cited by 12 publications

References 26 publications

Association of Mitral Annular Calcification with Left Ventricular Mechanics: A Speckle Tracking Study

Association of Mitral Annular Calcification with Left Ventricular Mechanics: A Speckle Tracking Study

Is the Presence of Mitral Annular Calcification Associated with Poor Left Atrial Function?

Plaque Vulnerability as Assessed by Radiofrequency Intravascular Ultrasound in Patients with Valvular Calcification

Contact Info

Product

Resources

About