Mitral Peak Doppler E-wave to Peak Mitral Annulus Velocity Ratio Is an Accurate Estimate of Left Ventricular Filling Pressure and Predicts Mortality in End-stage Renal Disease

Sharma, Rajan; Pellerin, Denis; Gaze, David; Mehta, Rajnikant; Gregson, Helen; Streather, Christopher P.; Collinson, Paul; Brecker, Stephen

doi:10.1016/j.echo.2005.10.006

Cited by 128 publications

(103 citation statements)

References 39 publications

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“…However, there is so far no comparative study on the diagnostic value of the E/Em ratio in dialysis patients compared with heart failure patients without renal failure. In an ESRD population, an E/Em ratio Ն15 was associated with a sensitivity of 82% and a specificity of 88% in predicting LV end-diastolic pressure Ͼ15 mmHg (14). Our recent study shows that increasing age, systolic dysfunction, LV volume index, and loss of residual renal function are all significant, independent predictors of an E/Em ratio Ն15 in ESRD.…”

Section: Discussionmentioning

confidence: 75%

Heart Failure in Long-Term Peritoneal Dialysis Patients

Wang¹,

Wang²,

Lam³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Heart failure occurs frequently in end-stage renal disease patients. However, there are no prospective, longitudinal follow-up data on its prevalence, severity, and risk factors in longterm peritoneal dialysis (PD) patients.Design, setting, participants, & measurements A prospective observational study was conducted in 220 longterm PD patients followed up for 4 years or until death. Echocardiography was obtained at baseline. Primary study end points were heart failure and mortality.Results Eighty-six patients had a previous history of heart failure at study entry. The cumulative 4-year survival probability was 37.4% and 64.7% for patients with and without previous heart failure, respectively (P Ͻ 0.0001). During follow-up, 87 patients (40.9%) developed heart failure, of which 53 were recurrence and 34 were new-onset heart failure. Diabetes, background atherosclerotic vascular disease, systolic hypertension, left ventricular (LV) mass index, systolic dysfunction, and hypoalbuminemia were significant risk factors predicting heart failure in the entire cohort. Diabetes and LV mass and volume index were significant predictors of new-onset heart failure. Systolic hypertension, LV volume index, and hypoalbuminemia were significant predictors of recurrent heart failure.Conclusions Heart failure is a highly prevalent complication in long-term PD patients and predicts adverse clinical outcomes. More attention should be focused on improving BP and volume control and identifying treatment strategies that effectively lower atherosclerotic burden and reverse LV hypertrophy, remodeling, and systolic dysfunction in PD patients.

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Section: Discussionmentioning

confidence: 75%

Heart Failure in Long-Term Peritoneal Dialysis Patients

Wang¹,

Wang²,

Lam³

et al. 2011

Clinical Journal of the American Society of Nephrology

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“…Numerous studies have shown a correlation of the E/e ratio with adverse events after acute myocardial infarction, hypertensive cardiomyopathy, and ESRD. [30][31][32][33] The velocity of e is dependent on changes of preload, afterload, the procedure should be performed in selected patients during the early period of dialysis treatment. Furthermore, early implementation of the procedure might improve patients' survival after transplantation.…”

Section: 28mentioning

confidence: 99%

Beneficial effect of bilateral native nephrectomy as complete denervation on left ventricular mass and function in renal transplant recipients

Obremska¹,

Boratyńska²,

Zyśko³

et al. 2016

Polish Archives of Internal Medicine

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“…Tissue Doppler is less sensitive to alterations in preload, being important in the categorization of LV diastolic function 11 and is an independent predictor of death and cardiovascular events in patients with CKD 29,30 . The only study that evaluated the evolution of tissue Doppler before and after kidney transplantation showed that the e' wave increased significantly from 5.6 cm/s to 6.5 cm/s in a follow-up of 4.2 years 29 , indicating an improvement of diastolic function.…”

Section: Discussionmentioning

confidence: 99%