Mitral Valve Annuloplasty Failure and Percutaneous Treatment Options

Joseph, Kara M.; Nyman, Charles

doi:10.1007/s11886-021-01574-4

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…The risks of an overly aggressive repair include inducing mitral stenosis or systolic anterior motion (SAM), both of which may require reoperation. 21,22 Additional operations are associated with an up to 3 times increase in the risk of perioperative mortality. 23 We aim to simplify mitral valve repair by eliminating the need to maintain proficiency in a large number of surgical techniques and instead rely solely on the ability to implant an annuloplasty ring, a procedure that is familiar to nearly all cardiac surgeons.…”

Section: Introductionmentioning

confidence: 99%

Proof of Concept: Development of a Mitral Annuloplasty Ring With Crosshatch Net

Seadler,

Joyce,

Zelten

et al. 2024

Innovations�(Phila)

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Objective: Here we report our preclinical, proof-of-concept testing to assess the ability of a novel device to correct mitral regurgitation. The Milwaukee Heart device aims to enable any cardiac surgeon to perform high-quality mitral valve repair using a standard annuloplasty ring with a crosshatch of microporous, monofilament suture. Methods: Hemodynamic, echocardiographic, and videographic data were collected at baseline, following induction of mitral regurgitation, and after repair using porcine hearts in an ex vivo biosimulator model. A commercially available cardiac prosthesis assessment platform was then used to assess the hydrodynamic characteristics of the study device. Results: Porcine biosimulator pressure and flow metrics exhibited successful correction of mitral regurgitation following device implantation with similar values to baseline. Hydrodynamic results yielded pressure gradients and an effective orifice area comparable to currently approved prostheses. Conclusions: The study device effectively reduced mitral valve regurgitation and improved hemodynamics in our preclinical model with similar biophysical metrics to currently approved devices. Future in vivo trials are needed to evaluate the efficacy, biocompatibility, and freedom from the most likely adverse events, such as device thrombosis, embolic events, and hemolysis.

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Section: Introductionmentioning

confidence: 99%

Proof of Concept: Development of a Mitral Annuloplasty Ring With Crosshatch Net

Seadler,

Joyce,

Zelten

et al. 2024

Innovations�(Phila)

View full text Add to dashboard Cite

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Clinical Impact of Computational Heart Valve Models

et al. 2022

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This paper provides a review of engineering applications and computational methods used to analyze the dynamics of heart valve closures in healthy and diseased states. Computational methods are a cost-effective tool that can be used to evaluate the flow parameters of heart valves. Valve repair and replacement have long-term stability and biocompatibility issues, highlighting the need for a more robust method for resolving valvular disease. For example, while fluid–structure interaction analyses are still scarcely utilized to study aortic valves, computational fluid dynamics is used to assess the effect of different aortic valve morphologies on velocity profiles, flow patterns, helicity, wall shear stress, and oscillatory shear index in the thoracic aorta. It has been analyzed that computational flow dynamic analyses can be integrated with other methods to create a superior, more compatible method of understanding risk and compatibility.

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Mitral Valve Annuloplasty Failure and Percutaneous Treatment Options

Cited by 2 publications

References 51 publications

Proof of Concept: Development of a Mitral Annuloplasty Ring With Crosshatch Net

Proof of Concept: Development of a Mitral Annuloplasty Ring With Crosshatch Net

Clinical Impact of Computational Heart Valve Models

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