Mitral valve prolapse

Althunayyan, Aeshah; Petersen, Steffen E.; Lloyd, Guy; Bhattacharyya, Sanjeev

doi:10.1080/14779072.2019.1553619

Cited by 34 publications

(37 citation statements)

References 73 publications

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“…Частота його зустрічаємості складає 2-3% серед всього населення [3]. Ця патологія займає важливе місце в структурі серцево-судинної патології, що пов'язано з ускладненнями, які можуть при цьому виникати [4,5], серед найнебезпечніших яких є раптова смерть [6,7]. Наявність незначних вад серця пред'являє підвищені вимоги до його роботи навіть в стані спокою.…”

Section: стан серцево-судинної системи у дітей з пролапсом мітральногunclassified

Condition of Cardiovascular System in Children with Mitral Valve Prolapse and its Response to Physical Activity

Кулешов¹,

Medrazhevska²,

Fik³

et al. 2019

Ukr. ž. med. bìol. sportu

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Section: стан серцево-судинної системи у дітей з пролапсом мітральногunclassified

Condition of Cardiovascular System in Children with Mitral Valve Prolapse and its Response to Physical Activity

Кулешов¹,

Medrazhevska²,

Fik³

et al. 2019

Ukr. ž. med. bìol. sportu

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“…[25] Fibroelastic deficiency is a focal fibrillin deficiency, most commonly affecting the medial posterior (P2) scallop and associated with overall thin leaflet tissue and focally ruptured degenerative chordae. [26] This often-focal pathology affords a focal surgical solution. The diffuse degenerative disease includes excess leaflet tissue secondary to mucopolysaccharide accumulation in leaflet mucosa and extensively involves both leaflets with multi-segmental prolapse.…”

Section: Step-2: Quantify the Main (Principal) Lesionmentioning

confidence: 99%

Echocardiographic prediction of surgical reparability in degenerative mitral regurgitation due to leaflet prolapse: a review

Mantovani

Bursi

Giannuario

et al. 2019

Expert Review of Cardiovascular Therapy

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Introduction. Despite current guidelines provide recommendations for the optimal management of degenerative mitral regurgitation (MR), this condition remains often undertreated with delay in surgical referral and dismal effect on outcomes.Areas covered. This review focuses on the role of echocardiography in guiding mitral valve (MV) surgical repair in degenerative MR due to leaflet prolapse. Expert opinion.A stepwise protocol-driven echocardiography shared by referring physician and surgeon may help to guide referral to surgical repair in degenerative MR. This protocol particularly is useful to identify the ideal patho-anatomy for a successful and durable repair especially when early surgery is proposed and to refer the patient to centers of excellence in case of complex anatomy. Nearly 100% repair rate can be achieved when the surgical technique is adapted to the lesions seen in each valve. Threedimensional echocardiography predicts repair complexity may be useful and should therefore be implemented. However, the current literature is far from comprehensive deriving from small, single-center studies. Therefore, reproducibility and external validation, especially with newly developed quantitative automated software, are still needed.

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“…The clinical presentation differs between patients with MVP. While one can be an asymptomatic female patient with mid-systolic click and late systolic murmur, the other patient may come with chest pain, palpitation, syncope, or dyspnea [ 2 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Outcome of Ventricular Arrhythmias Associated With Mitral Valve Prolapse After Catheter Ablation: A Systematic Review and Meta-Analysis

Wibawa¹,

Ivan²,

Jessica³

et al. 2021

Cureus

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The presence of mitral valve prolapse (MVP) varies from asymptomatic to life-threatening arrhythmias. Catheter ablation (CA) is widely used to treat ventricular arrhythmias (VAs) associated with MVP. Despite having high procedural success, outcome data after CA is limited, especially in a long-term setting. Therefore, this systematic review and meta-analysis were performed. Literature searching was conducted in Pubmed, EuropePMC, Proquest, and Ebsco from inception to December 2020 using keywords: ventricular arrhythmia, premature ventricular complex, ventricular tachycardia, ventricular fibrillation, mitral valve prolapse, and catheter ablation. A total of 407 potential articles were retrieved for further review. The final review resulted in six articles for systematic review and meta-analysis. The study was registered in PROSPERO (CRD42020219144). The most common origin of VAs was papillary muscle. The acute success rate of CA in the MVP group varies between 66% and 94%. Follow-up studies reported a higher percentage of VAs recurrence after CA in the MVP group (22.22%) compared with the non-MVP group (11.38%). However, the difference is not significant (P-value = 0.16). Other studies reported a 12.5%-36% rate and 40% of repeat ablation in the medium term and the long term, respectively. Episodes of sudden cardiac death during exertion could still occur following CA in patients with MVP. Distinct origin of VAs was observed during repeated ablation procedures, which may explain arrhythmic substrate progression. Diffuse left ventricular fibrosis around papillary muscle rather than local fibrosis was observed among older patients. Furthermore, the presence of mitral annular disjunction (MAD) and Filamin C mutation might increase the risk of recurrent VAs. CAn has been done as the treatment of VAs associated with MVP. The acute success rate of CA varies between studies and the number of patients requiring repeat CA varied from 12.5% to 40%. Sudden cardiac death could still occur after CA. Older age during CA, genetic predisposition, deep arrhythmic foci, multifocal VAs origin, diffuse fibrosis, and the presence of MAD may contribute to the recurrence of VAs. Further studies, stratification, and evaluation are needed to prevent fatal outcomes in VA associated with MVP, even after CA.

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Mitral valve prolapse

Cited by 34 publications

References 73 publications

Condition of Cardiovascular System in Children with Mitral Valve Prolapse and its Response to Physical Activity

Condition of Cardiovascular System in Children with Mitral Valve Prolapse and its Response to Physical Activity

Echocardiographic prediction of surgical reparability in degenerative mitral regurgitation due to leaflet prolapse: a review

The Outcome of Ventricular Arrhythmias Associated With Mitral Valve Prolapse After Catheter Ablation: A Systematic Review and Meta-Analysis

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