Mitral valve prolapse-click syndrome

Jeresaty, Robert M.

doi:10.1016/s0033-0620(73)80026-x

Cited by 249 publications

(30 citation statements)

References 72 publications

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“…The mitral valve's chronic fibrosis, also known as degenerative myxomatous mitral valve (DMMV), has a predisposition to affect older dogs and small breeds (O'Grady 1997), characterized by normal valvular architecture loss due to increasing fundamental substance with no inflammatory reaction tissue replacement by fibrous myxomatous tissue (Jeresaty 1974, Mucha 2007). Its etiology is still unknown, although different mechanisms may be involved, such as genetics, thoracic trauma, bacterial endocarditis and valve prolapse (Swenson et al 1996, Perdersen 2000.…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of enalapril maleate and furosemide usage in dogs with degenerative myxomatous mitral valve, CHF functional class Ib

Franco¹,

Pereira²,

Camacho³

2011

Pesq. Vet. Bras.

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791Pesq. Vet. Bras. 31(9):791-797, setembro 2011 RESUMO.-[Avaliação clínica da utilização do maleato de enalapril e furosemida em cães com doença degenerativa mixomatosa da válvula mitral, classe funcional Ib.] A doença degenerativa mixomatosa da válvula mitral (DDMVM) é uma cardiopatia de alta incidência na clínica médica de pequenos animais, acometendo mormente cães idosos e raças de pequeno porte. Desta forma, foi realizada uma investigação científica objetivando avaliar clinicamente a utilização dos fármacos maleato de enalapril e furosemida em cães com a referida enfermidade na classe funcional Ib da ICC, antes e após a terapêutica implantada. Para isso, utilizaram-se 16 cães portadores da valvulopatia supracitada, distribuídos em dois grupos; com o primeiro recebendo furosemida (n=8) e o segundo maleato de enalapril (n=8), durante 56 dias. Os cães foram avaliados em quatro momentos (T0, T14, T28 e T56 dias) quanto aos sinais clínicos e parâmetros hematológicos e bioquímico-séricos, que incluíram concentrações séricas da enzima conversora da angiotensina (ECA) e aldosterona, como também avaliações radiográficas, eletrocardiográficas, ecodopplercardiográficas e da pressão arterial. Os resultados quanto aos parâmetros clínicos, avaliações hematológicas e bioquímicas séricas não revelaram alterações significativas em ambos os grupos, mas reduções significativas nos valores de ECA e aldosterona no grupo que recebeu o maleato de enalapril foram identificadas. Ao exame radiográfico obser- Degenerative myxomatous mitral valve (DMMV) is a heart disease of high incidence in small animal clinical medicine, affecting mainly older dogs and small breeds. Thus, a scientific investigation was performed in order to evaluate the clinical use of the medicines furosemide and enalapril maleate in dogs with this disease in CHF functional class Ib before and after the treatment was established. For this purpose 16 dogs with the given valve disease were used, separated into two groups: the first received furosemide (n=8) and the second received enalapril maleate (n=8) throughout 56 days. The dogs were evaluated in four stages (T0, T14, T28 and T56 day) in relation to clinical signs, hematological, biochemical and serum assessment, which included serum angiotensin converting enzyme (ACE) and aldosterone, as well as radiography, electrocardiography, Doppler-echocardiography and blood pressure. The results regarding the clinical, hematological and serum chemistry evaluations revealed no significant changes in both groups, but significant reductions in the values of ACE and aldosterone in the group receiving enalapril maleate were verified. The radiographic examination revealed reductions of VHS values and variable Pms wave of the electrocardiogram in both groups, but no changes in blood pressure values were identified. The echocardiogram showed a significant decrease of the variables LVDd/ s in the studied groups and the FS% in animals that received only enalapril. Therefore, analysis of results showed that monotherapy based on e...

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Section: Introductionmentioning

confidence: 99%

Clinical evaluation of enalapril maleate and furosemide usage in dogs with degenerative myxomatous mitral valve, CHF functional class Ib

Franco¹,

Pereira²,

Camacho³

2011

Pesq. Vet. Bras.

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“…Several recent reports have emphasized the clinical features of mitral valve prolapse [1][2][3]. Chest pain and palpitations are frequent presenting complaints.…”

Section: Discussionmentioning

confidence: 99%

“…Mitral valve prolapse is a well recognized clinical entity [1][2][3], Several workers have described the auscultatory features associated with this syndrome. A mid or late systolic click and a late systolic murmur are thought to be characteristic findings in mitral valve prolapse.…”

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confidence: 99%

On the Frequency of Early Systolic Clicks in Mitral Valve Prolapse

Chandraratna¹

1977

Cardiology

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Phonocardiography was performed in 74 patients with mitral valve prolapse. 24 patients had early systolic clicks ( < 80 msec from S₁). Four of them had associated systolic murmurs. 30 patients had mid or late systolic clicks ( > 80 msec from S₁). A systolic murmur followed the click in 13 of these patients. Both an early and mid/late systolic click were noted in three patients. 17 patients did not have systolic clicks. Eight of these patients had holosystolic murmurs and two had late systolic murmurs. Seven patients had ‘silent’ mitral valve prolapse. In summary, early systolic clicks are common in mitral valve prolapse. In many instances the early click is not accompanied by a murmur. Echocardiography is recommended in patients with chest pain or arrhythmia of uncertain etiology, even if characteristic signs of mitral valve prolapse are absent.

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“…Several recent studies have provided detailed information regarding the morphologic [1,3,9,15,20], pathophysiologic [14,15,23,26], clin ical [2,7,13,15,30], hemodynamic [2,20], echocardiographic [8,10,11,27,29,35], angiographic [2,5,12,20,30,32], and epidemiologic [4,21,28] aspects of prolapsed mitral valve.…”

Section: Introductionmentioning

confidence: 99%

“…It is now well known that the majority of patients with prolapsed mitral valve have a benign clinical course [1,3,15], However, some of them for unknown reasons, develop life-threatening arrythmias, including sudden death [16], severe mitral regurgitation, or bacterial endocarditis [1,3,18]. The purpose of this study was to define the incidence of pro lapsed mitral valve in patients undergoing diagnostic cardiac catheteriza tions and to compare the angiographic findings with échocardiographie findings.…”

Section: Introductionmentioning

confidence: 99%

Prolapse of the Mitral Valve: Clinical, Hemodynamic, Angiographic and Echocardiographic Correlations

Iskandrian¹,

Kotler²,

Kimbiris³

et al. 1978

Cardiology

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Among 1,519 patients undergoing diagnostic cardiac catheterization over a 2-year period, angiographically unequivocal mitral valve prolapse was identified in 79 cases (5.2%). Mitral valve prolapse was clinically unsuspected in 30 of these 79 patients. Echocardiographic studies were available in 44 cases, but only 55% of the patients with prolapse of the mitral valve documented by angiography had positive echocardiographic findings. One third of the patients had associated coronary artery disease, aortic valve disease or atrial septal defects. 14 patients (18%) had moderate or severe mitral regurgitation. There was a wide spectrum of hemodynamic and ventriculographic abnormalities that could not entirely be explained by the degree of prolapse, by the severity of mitral regurgitation or by the presence of associated diseases.

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Mitral valve prolapse-click syndrome

Cited by 249 publications

References 72 publications

Clinical evaluation of enalapril maleate and furosemide usage in dogs with degenerative myxomatous mitral valve, CHF functional class Ib

Clinical evaluation of enalapril maleate and furosemide usage in dogs with degenerative myxomatous mitral valve, CHF functional class Ib

On the Frequency of Early Systolic Clicks in Mitral Valve Prolapse

Prolapse of the Mitral Valve: Clinical, Hemodynamic, Angiographic and Echocardiographic Correlations

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