Mitrephora chulabhorniana (Annonaceae), an extraordinary new species from southern Thailand

Damthongdee, Anissara; Aongyong, Kithisak; Chaowasku, Tanawat

doi:10.1007/s12228-019-09573-0

Cited by 8 publications

(10 citation statements)

References 18 publications

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“…Resazurin was used as the indicator. The test microbes were E. coli ATCC 25922 (Croxen et al, 2013), S. aureus ATCC 25923 (Tong et al, 2015), P. aeruginosa (Duraisingham et al, 2014), E. faecalis (Anderson et al, 2016), A. baumannii (Howard et al, 2012), K. pneumoniae (Paczosa et al, 2016), and C. albicans (Martins et al, 2014). Pseudomonas aeruginosa, E. faecalis, A. baumannii, K. pneumoniae, and C. albicans were collected and isolated from patients at Maharaj Nakhon Si Thammarat Hospital.…”

Section: Antimicrobial Assaymentioning

confidence: 99%

Antibacterial and antioxidant activities of methanolic leaf extracts of some Annonaceous plants found in Nakhon Si Thammarat, Thailand

Wungsintaweekul¹

2022

J App Pharm Sc

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The leaves of 20 species belonging to the Annonaceae family were collected and extracted using methanol to obtain scientific data to evaluate their potential use as new sources of medicinal agents. Methanolic leaf extracts 1-20 were subjected to phytochemical screening and a biological activity assay. The multipharmacophore of the natural products with the synergistic action was remarked as the target. The antimicrobial activity assay was done in parallel with the antioxidant activity test. Among these 20 extracts, extracts 1 and 4 exhibited the inhibition of the growth of all the test microbes. Flavonoids and tannins seem to be the main components of this action. Dramatic results indicate that extract 1 was the most active as an antioxidant. This research was the first report on the biological activities of extract 20. Extract 20 exhibited bactericidal activity against Enterococcus faecalis at 1,000 μg/ml. Terpenes might be the main component of this action. This result was related to the antimicrobial activity of extract 2 which contains terpenes and exhibited high antimicrobial activities against Staphylococcus aureus and E. faecalis (minimum inhibition concentration, MIC = 250 μg/ml). These data indicated a promising potential for Annonaceous plants to be used as sources of naturally occurring medicinal agents.

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Section: Antimicrobial Assaymentioning

confidence: 99%

Antibacterial and antioxidant activities of methanolic leaf extracts of some Annonaceous plants found in Nakhon Si Thammarat, Thailand

Wungsintaweekul¹

2022

J App Pharm Sc

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“…Mitrephora chulabhorniana (Annonaceae), known as Phrom Chulabhorn in Thai, is a remarkable new species discovered in a karst area in southern Thailand [ 16 ]. Different secondary metabolites including alkaloids, diterpenoids, dihydrobenzofuran lignans, and polyphenolic compounds have been reported to be concentrated in Mitrephora plants [ 17 – 24 ].…”

Section: Introductionmentioning

confidence: 99%

The Leaf Extract of Mitrephora chulabhorniana Suppresses Migration and Invasion and Induces Human Cervical Cancer Cell Apoptosis through Caspase‐Dependent Pathway

Nimlamool

Chansakaow

Potikanond

et al. 2022

BioMed Research International

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Cervical cancer is rated to be the leading cause of cancer-related death in women worldwide. Since screening test and conventional treatments are less accessible for people in developing countries, an alternative use of medicinal plants exhibiting strong anticancer activities may be an affordable means to treat cervical cancer. Mitrephora chulabhorniana (MC) is the newly identified species; however, its biological functions including anticancer activities have been largely unexplored. Hence, in this study, we were interested in investigating anticancer effects of this plant on the human cervical cell line (HeLa). MC extract was profiled for phytochemicals by TLC. This plant was tested to contain alkaloids, flavonoids, and terpenes. HeLa cells were treated with MC extract to investigate the anticancer activities. Cytotoxicity and viability of cells treated with MC were determined by MTT assay and Trypan blue exclusion assay. Cell migration was tested by wound healing assay, and cell invasion was determined by Transwell assay. The level of caspase 7, caspase 9, and PARP was determined by western blot analysis. We found that the leaf extract of MC strongly reduced cancer cell survival rate. This finding was consistent with the discovery that the extract dramatically induced apoptosis of cervical cancer cells through the activation of caspase 7 and caspase 9 which consequently degraded PARP protein. Furthermore, MC extract at lower concentrations which were not cytotoxic to the cancer cells showed potent inhibitory activities against HeLa cervical cancer cell migration and invasion. Mitrephora chulabhorniana possesses its pharmacological properties in inhibiting cervical cancer cell migration/invasion and inducing apoptotic signaling. This accumulated information suggests that Mitrephora chulabhorniana may be a beneficial source of potential agents for cervical cancer treatment.

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“…(Damthongdee & Chaowasku, 2018), Mitrephora Hook.f. & Thomson (Damthongdee et al, 2019;, Polyalthia Blume (Bunchalee et al, 2019), Pseuduvaria Miq. (Yoosukkee et al, 2021), Trivalvaria (Miq.)…”

Section: Introductionmentioning

confidence: 99%

Additions to Annonaceae in the Flora of Thailand

Johnson

Bunchalee

Chalermglin

et al. 2021

Thai Forest Bull., Bot.

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Mitrephora chulabhorniana (Annonaceae), an extraordinary new species from southern Thailand

Cited by 8 publications

References 18 publications

Antibacterial and antioxidant activities of methanolic leaf extracts of some Annonaceous plants found in Nakhon Si Thammarat, Thailand

Antibacterial and antioxidant activities of methanolic leaf extracts of some Annonaceous plants found in Nakhon Si Thammarat, Thailand

The Leaf Extract of Mitrephora chulabhorniana Suppresses Migration and Invasion and Induces Human Cervical Cancer Cell Apoptosis through Caspase‐Dependent Pathway

Additions to Annonaceae in the Flora of Thailand

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