MIUH Inhibits the Hippocampal Neuron Growth in Fetal Rat by Affecting the PTEN Pathway

Prenatal systemic hypoxia-ischemia: A rat model of neurodevelopmental disorders related to prematurity

“…In addition, prenatal TSHI induced to premature loss of the subplate and cortical plate, leading to abnormalities in cortical differentiation and gyrification (Jantzie et al, 2015a). It is worth to note that MIUH at E17.5 appeared to reduce early neuronal proliferation and to increase neuronal apoptosis of fetal neurons and autophagy from E18 to P28 in the hippocampus concomitant to alterations of Wnt, Akt and PTEN signaling pathways (Yin et al, 2020(Yin et al, , 2021. MIUH at E17 induced mRNA changes, indicative of incomplete axonal outgrowth and astrocyte dysfunction but little to no impairment of immature neurons and pre-oligodendrocytes in MIUH fetuses at E20 (Ohshima et al, 2016).…”

Umbilical cord-derived mesenchymal stromal cell therapy to prevent the development of neurodevelopmental disorders related to low birth weight

“…This tendency was also observed, although less signi cantly, in the brains of fetuses 10,12 . In recent studies, signs of in ammation were con rmed using models with comparable MIUH [13][14][15] . In addition, rats with MIUH-induced LBW exhibited hyperactivity, impaired sensory input integration, memory de cits, minor postural and locomotor de cits, anatomical and functional disorganization, and sensorimotor circuit hyperexcitability 10-12, 16,17 .…”