Mixed Acinar-Endocrine Carcinoma (MAEC) Arising in Duodenal Pancreatic Heterotopia

Bell, Phoenix; DeRoche, Tom C.; Huber, Aaron R

doi:10.1155/2019/1713546

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Since then, a total of 13 cases of gastric ACCs (including ACCs that also contain neuroendocrine tumor cells) have been reported [3,[5][6][7][8][9][10][11][12]. In addition, there are other reports of ACCs in the duodenum, papilla, small intestine and liver; ACCs that develop outside the pancreas are often called pancreatic-type ACCs [13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Title: pancreatic‐type mixed acinar neuroendocrine carcinoma of the stomach: a case report and review of the literature

et al. 2021

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Background The majority of gastrointestinal tumors are adenocarcinomas. Rarely, there are other types of tumors, such as acinar cell carcinoma, and these are often called pancreatic-type acinar cell carcinomas. Among these tumors, some are differentiated into neuroendocrine components. A few of them are MiNENs. Case presentation The patient was an 80-year-old male who was referred to our hospital for treatment of a pedunculated gastric tumor. It was 5 cm in diameter and detected in the upper gastric body with upper GI endoscopy conducted to investigate anemia. In the biopsy, although hyperplasia of gastric gland cells was noted, no tumor cells were found. Retrospectively, the diagnosis was misdiagnosed. An operation was arranged because bleeding from the tumor was suspected as a cause of anemia and because surgical resection was considered to be desirable for accurate diagnosis. Hence, laparoscopic and endoscopic cooperative surgery was performed. In the pathological examination, several types of epithelial cells that proliferated in the area between the mucosa and deep inside the submucosa were observed. These consisted of acinar-glandular/trabecular patterns and solid. A diagnosis of pancreatic-type acinar cell carcinoma of the stomach with NET G2 and G3 was made based on characteristic cellular findings and the results of immunostaining tests. Each of them consisted of more than 30% of the lesion; a diagnosis of pancreatic-type mixed acinar neuroendocrine carcinoma (pancreatic-type MiNEN) of the stomach or a type of gastric MiNEN was obtained. Anemia was resolved after the operation, and the patient was discharged from the hospital without perioperative complications. Conclusions Pancreatic-type ACC of the stomach that is differentiated into neuroendocrine tumors is very rare. Hence, we report this case along with a literature review.

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Section: Discussionmentioning

confidence: 99%

Title: pancreatic‐type mixed acinar neuroendocrine carcinoma of the stomach: a case report and review of the literature

et al. 2021

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“…Pancreatic mixed neuroendocrine neoplasm is a rare cancer of pancreas and rare cases have been reported in pancreatic heterotopia [2].…”

Section: Discussionmentioning

confidence: 99%

Mixed Acinar- Neuroendocrine Carcinoma of the Pancreas: A Rare Case Report with Comprehensive Review of Literature

Arshi¹,

Rao²

2021

JJGH

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“…Since then, a total 13 cases have been reported on gastric ACCs (including ACCs which also contained neuroendocrine tumor cells) 3, 5-12 . In addition, there are also other reports of ACC in the duodenum, papilla, small intestine and liver; such ACCs which developed outside the pancreas are often called as pancreatic-type ACCs [13][14][15][16][17] .…”

Section: Discussionmentioning

confidence: 99%

Pancreatic-Type Mixed Acinar Neuroendocrine Carcinoma of the Stomach: A Case Report And Review of Literature

Ooe

WATANABE²,

HASHIMOTO

et al. 2020

Preprint

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Background: A majority of gastrointestinal tumors are adenocarcinoma. Rarely, there is also a type of tumors such as acinar cell carcinoma, which are often called pancreatic-type acinar cell carcinoma. Among those, some are differentiated into neuroendocrine components. A few of them can be called MiNENs. Case presentation: The patient was an 80-year old male who was referred to our hospital for treatments of a pedunculated gastric tumor. It was 5 cm in diameter and detected in the upper gastric body with upper GI endoscopy conducted for investigation of anemia. In the biopsy, although a kind of hyperplasia of gastric gland cell was pointed out, no tumor cells were found. Retrospectively, the diagnosis was turned out to be a misdiagnosis. An operation was arranged because bleeding from the tumor was suspected as a cause of anemia and because a surgical resection was considered to be desirable for accurate diagnosis. Hence, laparoscopy and endoscopy cooperative surgery was performed. In pathological examination, several types of epithelial cells which proliferated in the area between mucosa and deep inside the submucosa were observed. These consisted of acinar-glandular/trabecular patterns and solid pattern. A diagnosis of pancreatic-type acinar cell carcinoma of the stomach with NET G2 and G3 was made based on characteristic cellular findings and the result of immunostaining tests. Each of them consisted of more than 30% of the lesion; a diagnosis of pancreatic-type mixed acinar neuroendocrine carcinoma (pancreatic-type MiNEN) of the stomach, or a type of gastric MiNEN was obtained. Anemia was resolved after operation, and the patient was discharged from the hospital without perioperative complications. Conclusions: Pancreatic-type ACC of the stomach which is differentiated into neuroendocrine tumor is very rare. Hence, we report this case along with several literature reviews.

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Mixed Acinar-Endocrine Carcinoma (MAEC) Arising in Duodenal Pancreatic Heterotopia

Cited by 3 publications

References 20 publications

Title: pancreatic‐type mixed acinar neuroendocrine carcinoma of the stomach: a case report and review of the literature

Title: pancreatic‐type mixed acinar neuroendocrine carcinoma of the stomach: a case report and review of the literature

Mixed Acinar- Neuroendocrine Carcinoma of the Pancreas: A Rare Case Report with Comprehensive Review of Literature

Pancreatic-Type Mixed Acinar Neuroendocrine Carcinoma of the Stomach: A Case Report And Review of Literature

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