Mixed Avanafil and Dapoxetin Hydrochloride cyclodextrin nano-sponges: Preparation, in-vitro characterization, and bioavailability determination

Gardouh, Ahmed; Elhusseiny, Sameh; Gad, Shadeed

doi:10.1016/j.jddst.2022.103100

Cited by 9 publications

(4 citation statements)

References 48 publications

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“…The choice of the method adopted in the development of NS depends on the nature of drug as well as the effect required from the developed NS formulation. 51…”

Section: Degree Of Substitution and Methods Of Preparationmentioning

confidence: 99%

Nanosponges- A Versatile Approach of Drug Delivery System

Singh,

Chauhan

2023

IJPQA

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With the escalating number of diseases, an opportunistic target drug delivery system is needed. Nanosponges (NS) are nanosized drug delivery systems having three-dimensional (3D) configurations, fabricated by crosslinking of polymers to ensnare a wide assortment of drugs. These small particles move inside the body till they arrive at the target site and deliver the medication in a specific and controlled way. They can ensnare (entrap) both hydrophilic and hydrophobic moieties in a smarter manner and improve the solubility and bioavailability of drugs. NS have been utilized to examine the medication conveyance by oral, parenteral, and topical routes. Another significant property of NS is that they can work on the solvency of ineffectively water-soluble moieties and are utilized for the storage of gases, and proteins as well as for the removal of toxins from the systemic circulation. The present review highlights the types of nanosponges, their methods of preparation, characterization, and applications in drug delivery.

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“…The choice of the method adopted in the development of NS depends on the nature of drug as well as the effect required from the developed NS formulation. 51…”

Section: Degree Of Substitution and Methods Of Preparationmentioning

confidence: 99%

Nanosponges- A Versatile Approach of Drug Delivery System

Singh,

Chauhan

2023

IJPQA

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“…These two varieties of polymeric NPs are known as a matrix system (nanosphere) and a reservoir system (nano-capsule). Additionally, polymeric particles demonstrated their usefulness in stabilizing and shielding medicinal molecules like proteins, peptides, or DNA molecules against degradation caused by various environmental dangers (Gardouh et al, 2022). Therefore, these polymers offer the possibility of different protein and gene delivery (Jarai et al 2020;Zielińska et al 2020).…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Surfactants' Role in Nanovesicles Drug Delivery System

Gad,

Hanna,

Ibrahem

et al. 2023

Records of Pharmaceutical and Biomedical Sciences

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Over the past few decades, the systemic delivery of numerous active compounds through buccal mucosa has increased significantly. A prolonged residency time provides for more medication penetration after mucoadhesion. Wafers have a higher drug load than cast films because of their porous construction. These mucoadhesive buccal dosage forms provide painless administration, direct access to the systemic circulation via the inner jugular vein, the ability to use permeation enhancers or pH modifiers in the established systems, avoidance of potential gastrointestinal enzyme degradation, and the possibility of therapy discontinuation. Edge activators (EAs) and non-ionic surfactants make up most of the elastic surfactant-based vesicles known as nanospanlastics-the deformable nanocarriers known as spanlastics were created by Kakkar and Kaur and are based on surfactants. Non-ionic surfactants and EAs constitute the majority of spanlastics. By squeezing through various pores of the biological layers without rupturing, EAs increase the flexibility and permeability of the vesicular membranes of nanocarriers, destabilizing them and increasing their flexibility and crossmembrane permeability. Inert, biodegradable, and safe deformable nanovesicles are called spanlastics. They also have more chemical stability than standard liposomes.

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“…Palminteri et al [ 66 ] constructed a novel system using cyclodextrin-centered nanosponges for transferring the glutathione-mediated transport of resveratrol into the targeted cancerous cells. In addition, the oral bioavailability of avanafil and dapoxetin was improved by applying cyclodextrin-based nanosponges [ 67 ]. Magnetic nanosponges have shown great potential for targeted drug delivery as well [ 68 ].…”

Section: Drug Delivery and Cancer Therapymentioning

confidence: 99%

Nanosponges for Drug Delivery and Cancer Therapy: Recent Advances

Iravani

Varma

2022

Nanomaterials

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Nanosponges with three-dimensional (3D) porous structures, narrow size distribution, and high entrapment efficiency are widely engineered for cancer therapy and drug delivery purposes. They protect the molecular agents from degradation and help to improve the solubility of lipophilic therapeutic agents/drugs with targeted delivery options in addition to being magnetized to attain suitable magnetic features. Nanosponge-based delivery systems have been applied for cancer therapy with high specificity, biocompatibility, degradability, and prolonged release behavior. In this context, the drug loading within nanosponges is influenced by the crystallization degree. Notably, 3D printing technologies can be applied for the development of novel nanosponge-based systems for biomedical applications. The impacts of polymers, cross-linkers, type of drugs, temperature, loading and mechanism of drug release, fabrication methods, and substitution degree ought to be analytically evaluated. Eco-friendly techniques for the manufacturing of nanosponges still need to be uncovered in addition to the existing methods, such as solvent techniques, ultrasound-assisted preparation, melting strategies, and emulsion solvent diffusion methods. Herein, the recent advancements associated with the drug delivery and cancer therapy potential of nanosponges (chiefly, cyclodextrin-based, DNAzyme, and ethylcellulose nanosponges) are deliberated, focusing on the important challenges and future perspectives.

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Mixed Avanafil and Dapoxetin Hydrochloride cyclodextrin nano-sponges: Preparation, in-vitro characterization, and bioavailability determination

Cited by 9 publications

References 48 publications

Nanosponges- A Versatile Approach of Drug Delivery System

Nanosponges- A Versatile Approach of Drug Delivery System

Surfactants' Role in Nanovesicles Drug Delivery System

Nanosponges for Drug Delivery and Cancer Therapy: Recent Advances

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