Mixed Carcinoid-Adenocarcinoma of the Liver.

Abstract

A 61-year-old man with a mixed carcinoid-adenocarcinoma of the liver is described. Microscopic examination of the lesion showed a differentiated adenocarcinoma with distinct carcinoid components that stained positively for argyrophil. Thetumor cells contained serotonin granules on immunohistochemical studies. Detailed examination disclosed no primary tumor in the gastrointestinal tract or in any other organ. Resection was considered impractical because there were multiple tumors. The patient received chemotherapy six times (cisplatin 60 mg/m2, epirubicin 40 mg/ m2 per month). The multiple tumors gradually shrank. At the time of this writing, the patient is still alive. To our knowledge, this is the first reported case of mixed carcinoid-adenocarcinoma of the liver. (Internal Medicine 39: 910-913, 2000)

Neuroendocrine Tumors of the Hepatobiliary Tract

“…Very rarely, hepatic carcinoid arises as a composite tumor consisting of a neuroendocrine tumor and an adenocarcinoma/cholangiocarcinoma (Hidaka et al 2000;Koplin and Agni 2009). The cases histologically present as well-differentiated adenocarcinoma with components of argyrophil carcinoid tumor cells, the latter sometimes being immunohistochemically positive for serotonin.…”

Double Diagnosis in Cancer Patients and Cutaneous Reaction Related to Gemcitabine

“…[1][2][3][4][5][6][7] They seem to be derived from a multipotential stem cell capable of bidirectional differentiation and have a worse prognosis than ordinary carcinoma. [1][2][3][4][5][6][7] They seem to be derived from a multipotential stem cell capable of bidirectional differentiation and have a worse prognosis than ordinary carcinoma.…”