Mixed connective tissue disease with associated glomerulonephritis and hypocomplementaemia

Palferman, T G; McIntosh, Christina; Kershaw, Michael J.

doi:10.1136/pgmj.56.653.177

Cited by 7 publications

(3 citation statements)

References 10 publications

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“…In contrast, there are also some cases, including our case, which are accompanied with the amelioration of renal disease [3,10,16,21]. As shown in table II.…”

Section: Discussionmentioning

confidence: 66%

Renal Involvement in Mixed Connective Tissue Disease

et al. 1985

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5 cases with the compatible serological criteria of mixed connective tissue disease described earlier are presented. In 1 of them with a moderate degree of proteinuria, the renal biopsy disclosed membranous nephritis. However, despite the absence of overt clinical renal disease in the other 4 cases, biopsies disclosed membranous nephritis in 1 and mild mesangial proliferative glomerulonephritis in the remaining 3 cases. In the follow-up of these 4 cases, 2 subsequently developed abnormal urinalysis. Electron microscopic examinations demonstrated electron-dense deposits in glomeruli, and 4 of these patients also had microtubular structures in the endothelial cytoplasm. Contrarily to the original concept, our findings suggest that mixed connective tissue disease also induces immune complex disease.

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“…In contrast, there are also some cases, including our case, which are accompanied with the amelioration of renal disease [3,10,16,21]. As shown in table II.…”

Section: Discussionmentioning

confidence: 66%

Renal Involvement in Mixed Connective Tissue Disease

et al. 1985

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“…Reports describing pregnancies in patients with MCTD are rare, and the results have been contradictory: a high risk of fetal loss and of disease exacerbation or no influence on fetus or mother [2, 3, 4, 5]. Renal involvement in MCTD has been considered by some authors [6, 7, 8, 9, 10, 11, 12, 13]. We report here a patient with nephrotic syndrome secondary to MCTD and describe the course of her disease during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy Outcome in Nephrotic Syndrome with Mixed Connective Tissue Disease

Horita

Tsunoda

Inenaga

et al. 2001

Nephron

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We describe two pregnancies of a young woman with mixed connective tissue disease. In June 1983, she was diagnosed as having Raynaud’s phenomenon, arthralgia, and proteinuria. She then developed nephrotic syndrome. Methylprednisolone was initially prescribed at a large dose of 1 g/day which was slowly tapered to 5 mg/day. The proteinuria disappeared. During both pregnancies (the first beginning in December 1988 and the second in May 1992), the patient was placed on a prednisolone maintenance dose (5 mg/day). Both neonates were born healthy at term with no complications. Continuing prednisolone may be useful in pregnant women, and aggressive treatment to prevent mixed connective tissue disease exacerbation may be appropriate during pregnancy.

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“…Since that time, however, several cases of MCTD complicated by renal disease (Bennett and Spargo 1977;Fuller et al 1977; Singsen et al 1977; Cohen et al 1980;Palferman et al 1980) including some uremic cases (Kitridou et al 1980; Eberhardt et al 1981; Lemmer et al 1982) have been reported. In the present study, we analyzed histopathologically renal changes in MCTD, using morphometric method.…”

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confidence: 99%