Mixed Cryoglobulinemia in Chronic Hepatitis C Infection A Clinicopathologic Analysis of 10 Cases and Review of Recent Literature

Association between Type II Cryoglobulinemia and Hepatitis C Virus in a Case Treated with Interferon-Alpha

“…The fre quency of cryopheresis therapy could not be reduced because discontinuation of the ther apy resulted in worsening of renal function. Recently, the beneficial effect of interferon therapy on HCV-associated cryoglobulinem ia has been reported by several authors [2,3,[6][7][8][9]. In the present case, interferon-a thera py also had beneficial effects on renal func tion, such as reducing serum creatinine lev els and amounts of urinary protein, as well as reducing IgM and rheumatoid factor levels.…”

“…7. 9], and the effectiveness of interferon thera pies in reducing cryoglobulin [2,3,[6][7][8][9], There has. however, so far been no precise case report demonstrating a correlation asso ciation between states of cryoglobulinemia and serum titer of HCV during clinical use of interferon.…”

Treatment of mononeuropathy multiplex in hepatitis C virus and cryoglobulinemia

“…5,6 Uncontrolled patient reports suggest ␣-Ifn is also efficacious in the treatment of extrahepatic manifestations of HCV and mixed cryoglobulinemia, though in most polyneuropathy and treatment response are poorly defined. 3,11,14,15,17 One recent report of a patient with cryoglobulinemia and HCV suggested improvement of MMp with ␣-Ifn following disease progression on prednisone. 12 Another patient report described functional improvement of MMp with a combination of ␣-Ifn, prednisone, and cyclophosphamide, particularly after ␣-Ifn was initiated.…”

Hepatitis-C-Virus-assoziierte Dermatosen

“…Damit dürfte die HCV-Infektion als Hauptursache für die Entwicklung dieser Vaskulitis angesehen werden. Ebenso lassen sich bei mehr als 40% der Patienten mit chronischer Hepatitis C Kryoglobuline im Serum nachweisen; doch nicht inneren Organen [38,44], es wurde jedoch auch über eine Verschlechterung der Hautveränderungen darunter berichtet [41].…”