Mixed extragonadal germ cell tumour of the prostate

Antunes, Hugo; Almeida, Rui; Sousa, Vítor de; Figueiredo, Arnaldo

doi:10.1136/bcr-2017-223603

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…EGCTs are very rare but well-known neoplasms, arising principally from the mediastinum, retroperitoneum, thymus, or pineal gland, of which seminoma accounts for more than 60%[ 1 ]. Based on the current study, there have been a total of 14 cases of prostatic seminoma without testicular involvement, including 13 reported previously, of which 11 had primary pure seminoma and 3 had malignant embryonal tumour mixed with seminoma[ 13 - 15 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of primary seminoma of the prostate: A case report and review of literature

Cao¹,

Lian²,

Chen³

et al. 2023

World J Clin Cases

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BACKGROUND Primary seminoma of the prostate (PSP) is a rare type of extragonadal germ cell tumour that is easily misdiagnosed, owing to the lack of specific clinical features. It is therefore necessary for clinicians to work toward improving the accuracy of PSP diagnosis. CASE SUMMARY A 59-year-old male patient presenting with acute urinary retention was admitted to a local hospital. A misdiagnosis of benign prostatic hyperplasia led to an improper prostatectomy. Histopathology revealed PSP invading the bladder neck and bilateral seminal vesicles. Further radiotherapy treatment for the local lesion was performed, and the patient had a disease-free survival period of 96 mo. This case was analysed along with 13 other cases of PSP identified from the literature. Only four of the cases (28.6%) were initially confirmed by prostate biopsy. In these cases, imaging examinations showed an enlarged prostate (range 6-11 cm) involving the bladder neck (13/14). Of the 14 total cases, 11 (78.6%) presented typical pure seminoma cell features, staining strongly positive for placental alkaline phosphatase, CD117, and OCT4. The median age at diagnosis was 51 (range 27-59) years, and patients had a median progression-free survival time of 48 (range 6-156) mo after treatment by cisplatin-based chemotherapy combined with surgery or radiotherapy. The remaining three were cases of mixed embryonal tumours with focal seminoma, which had clinical features similar to those of pure PSP, in addition that they also had elevated serum alpha-fetoprotein, beta-human chorionic gonadotropin, and lactose dehydrogenase. CONCLUSION PSP should be considered in patients younger than 60 years with an enlarged prostate invading the bladder neck. Further prostate biopsies may aid in proper PSP diagnosis. Cisplatin-based chemotherapy is still the main primary therapy for PSP.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of primary seminoma of the prostate: A case report and review of literature

Cao¹,

Lian²,

Chen³

et al. 2023

World J Clin Cases

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“…The cases of prostate EGGCTs (primary or metastatic) reported in the literature were mainly treated before 2000, when complete surgical resection with pelvic exenteration was the standard of care. More recent cases were treated primarily with cisplatin-based ChT and underwent surgical resection only if residual lesions persisted (as in testicular GCTs), avoiding the unnecessary morbidity of surgery in patients without evidence of residual tumor [10][11][12][13][14][15][16][17]. In the case now reported, a TRUS biopsy established the diagnosis of a prostatic metastasis of a previously diagnosed primary testicular seminoma.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Isolated Prostate Recurrence From Testicular Seminoma

Albuquerque,

Timóteo,

Pestana

et al. 2023

Cureus

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We report the case of a 32-year-old male diagnosed with a left-sided testicular seminoma treated with radical inguinal orchiectomy and staged as pT1bN0M0S0 (rete testis invasion) -stage IA. Adjuvant treatment options were discussed, and active surveillance was chosen. Two years later, he presented with urinary retention alternating with pollakiuria, a feeling of incomplete bladder emptying, dyspareunia, and anejaculation. A rectal examination documented an enlarged, nodular, painful prostate. Blood and urine analyses, including serum tumor markers, were unremarkable. Pelvic magnetic resonance (MR) documented a central, nodular, solid, hypermetabolic, prostatic tumor with a size of 40x50x25 mm, invasion of the right seminal vesicle, right anterolateral wall of the rectum, and postero-inferior bladder wall, and an absent lymph node and visceral disease. A transrectal ultrasound-guided (TRUS) biopsy documented prostatic metastasis of the seminoma. The patient was treated with four cycles of bleomycin, etoposide, and cisplatin (BEP) chemotherapy (ChT) with a complete (clinical, radiologic, metabolic, and pathological) response. After five years of follow-up, he remains asymptomatic without a recurrence of the disease.

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“… 3 Extragonadal germ cell tumors (EGGCTs) originating in the prostate are extremely rare, with <20 cases described in the literature. 4 To the best of our knowledge, there are no published cases of primary embryonal carcinoma of the prostate to this day. The present study describes the case of a 24-year-old male with primary embryonal carcinoma of the prostate who sought medical assistance due to urinary retention.…”

Section: Introductionmentioning

confidence: 99%

Primary embryonal carcinoma of the prostate

Radovanović,

Zubelić,

Šantrić

et al. 2024

Urology Case Reports

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Mixed extragonadal germ cell tumour of the prostate

Cited by 3 publications

References 16 publications

Diagnosis and treatment of primary seminoma of the prostate: A case report and review of literature

Diagnosis and treatment of primary seminoma of the prostate: A case report and review of literature

A Rare Case of Isolated Prostate Recurrence From Testicular Seminoma

Primary embryonal carcinoma of the prostate

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