Mixed Germ Cell-Sex Cord Stromal Tumor of Testis: Incidental Finding of Rare Testicular Neoplasm

Rames, Ross; Richardson, Mary S.; Swiger, Frederick K.; Kaczmarek, A

doi:10.1016/s0022-5347(01)66901-5

Cited by 7 publications

(7 citation statements)

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“…When judging the figures of other published cases of testicular MGSCT [3,28], it seems that they were morphologically very similar to our cases. Typical for testicular MGSCTs in our series and those in the literature [3,28] is the SCC composed of spindle-shaped cells incorporating clusters of germ cells with a copious cytoplasm rendering them a targetoid appearance.…”

Section: Discussionsupporting

confidence: 86%

“…Typical for testicular MGSCTs in our series and those in the literature [3,28] is the SCC composed of spindle-shaped cells incorporating clusters of germ cells with a copious cytoplasm rendering them a targetoid appearance. In contrast, the SCC and germ cells of the ovarian MGSCTs differed from testicular MGSCTs.…”

Section: Discussionmentioning

confidence: 54%

“…They were first described by Masson as a Pflügerome in 1912 [21] and later as "epitheliomas pflugeriens" in 1923 [22]. Later, there were several cases published in the ovaries [1, 14, 19, 27, 32, 33, 35, 37, 38, 41, 47] and occasional cases in the testes [3,28,36,37]. However, the existence of these tumors in the testis has recently been questioned by a group of authors who reviewed nine testicular sex cord-stromal tumors containing germ cells, which closely mimicked MGSCT but differed from the latter, in that the germ cells were entrapped and nonneoplastic rather than neoplastic [43, 461.…”

Section: Discussionmentioning

confidence: 99%

“…Most cases of MGSCT were described in the ovaries [1,14,19,27,32,33,35,37,38,41,47]; however, there were also a few cases of MGSCT reported in the testis [3,8,28]. Yet the existence of these tumors in the testis had recently been questioned by a group of authors, who considered these lesions to represent sex cord-stromal tumors with entrapped germ cells rather than genuine MGSCT [43,46].…”

Section: Introductionmentioning

confidence: 99%

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Mixed germ cell sex cord–stromal tumors of the testis and ovary. Morphological, immunohistochemical, and molecular genetic study of seven cases

et al. 2006

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mixed germ cell sex cord–stromal tumors of the testis and ovary. Morphological, immunohistochemical, and molecular genetic study of seven cases

et al. 2006

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“…Unlike gonadoblastoma, which occurs in GD, MGCSCST occurs mostly in the ovaries of phenotypic women with the 46,XX karyotype. However, a few testicular unclassified MGCSCSTs in otherwise healthy men have also been reported (Talerman, 1980; Bolen, 1981; Matoska and Talerman, 1989; Rames et al, 1995; Ulbright et al, 2000).…”

mentioning

confidence: 99%

Neoplastic Potential of Germ Cells in Relation to Disturbances of Gonadal Organogenesis and Changes in Karyotype

Słowikowska-Hilczer

Romer²,

Kula

2003

Journal of Andrology

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The study consisted of 46 intersexual patients who underwent gonadectomy at the age of 3 months to 19 years because of gonadal dysgenesis (GD; 40 cases) or true hermaphroditism (bisexual gonads; 6 cases). In patients with GD, the incidence of the 46,XY karyotype was 67.5%, whereas the remaining patients exhibited numerical and structural aberrations of sex chromosomes (NSASs), and all patients with bisexual gonads revealed NSAS. Seminoma was diagnosed in 1 patient with the 46,XY karyotype and pure GD (streak gonads). Intratubular carcinoma in situ (CIS) appeared as an exclusive lesion in 61.5% of 13 patients with mixed GD, in 54% of 11 patients with partial GD (bilateral testes), in 16.7% of 6 patients with bisexual gonads, and in none of 13 patients with pure GD. CIS also appeared in tubules in the vicinity of sex cord-derived tumors (gonadoblastoma nests and unclassified mixed germ cell-sex cord-stromal tumor; MGCSCST) and within the tumors. In 3 patients, gonadoblastoma replaced the whole bilateral gonads and is referred to as gonadoblastoma-only GD. The incidence of neoplastic lesions (mostly bilateral) was 90.9% in patients with partial GD, 76.9% (mostly unilateral) in patients with mixed GD, 23.1% (unilateral) in patients with pure GD, and 16.7% (unilateral) in patients with bisexual gonads. Disregarding types of disturbances of gonadal organogenesis, the incidence of lesions was 71.4% in 28 patients with the 46,XY karyotype and 35.3% in 17 patients with NSAS. We conclude, first, that NSAS is not a prerequisite for the appearance of GD and GD is more frequently associated with the 46,XY karyotype. Second, the spectrum of germ cell neoplastic lesions in GD is wider than reported. Besides germ cell carcinoma, CIS, and gonadoblastoma nests, the spectrum also includes a tumor of gonadoblastoma-only in cases of GD and MGCSCST. Third, the incidence of neoplastic lesions is related more to the severity of the disturbances of gonadal organogenesis than it is to aberrations in sex chromosomes. Fourth, less disturbed testicular organogenesis predisposes these patients more toward germ cell neoplastic lesions, which suggests that the testicular environment of a dysgenetic gonad plays an important role in germ cell neoplasia initiation, maintenance, or both.

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Intratesticular leiomyosarcoma in a young man after high dose doping with oral-turinabol

Renshaw

2000

Cancer

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Mixed Germ Cell-Sex Cord Stromal Tumor of Testis: Incidental Finding of Rare Testicular Neoplasm

Cited by 7 publications

References 1 publication

Mixed germ cell sex cord–stromal tumors of the testis and ovary. Morphological, immunohistochemical, and molecular genetic study of seven cases

Mixed germ cell sex cord–stromal tumors of the testis and ovary. Morphological, immunohistochemical, and molecular genetic study of seven cases

Neoplastic Potential of Germ Cells in Relation to Disturbances of Gonadal Organogenesis and Changes in Karyotype

Intratesticular leiomyosarcoma in a young man after high dose doping with oral-turinabol

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