Mixed germ cell tumor of the pineal gland in a pediatric patient

Kabashi, Serbeze; Ahmetgjekaj, Ilir; Harizi, Edlira; Hyseni, Fjolla; Kola, Erisa; Vokshi, Valon; Hyseni, Guri; Kola, Ina; Haroon, Humza; Rahman, Masum; Shemsi, Kledisa; Decka, Arlind; Capi, Livia; Goçaj, Kaltrina; Musa, Juna

doi:10.1016/j.radcr.2022.05.024

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…The various clinical manifestations of germinoma are related to the size, the site, and the invasion extent of the tumor. Tumors located in the pineal region often block the midbrain corpora quadrigemina and cause hydrocephalus due to tumor protruding to the back of the third ventricle or invading the tetras downward, thus leading to headache, vomiting and other symptoms of elevated intracranial pressure, which can also be manifested as binocular hyperopia (Parinaud syndrome) ( 9 ). Germinoma in sellar region or suprasellar region is often accompanied by diabetes insipidus, precocious puberty or delay, hypothyroidism, growth hormone deficiency, adrenal insufficiency and other endocrine disorders, which may invade optic chiasma and cause vision loss or visual field defect ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Hemophagocytic lymphohistiocytosis during treatment of intracranial multifocal germinoma: a case report and literature review

Guo,

Liu,

Chen

et al. 2024

Front. Oncol.

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Hemophagocytic lymphohistiocytosis (HLH), also known as hemophagocytic syndrome (HPS), is a benign histiocytosis with hyperreactive proliferation of the mononuclear phagocyte system caused by immune function abnormalities, which often occurs under the background of genetic mutations, inflammation, infection or tumors. Because the research on malignancy-associated HLH (M-HLH) is focused on hematological malignancies, reports on HLH secondary to solid tumors are rare. In this case, we report a 14-year-old girl who developed HLH during treatment for intracranial multifocal germinoma, and the disease was controlled after hormone combined with etoposide(VP-16) and other related treatments. To our knowledge, there have been no documented cases of HLH caused by intracranial multifocal germinoma.

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Section: Discussionmentioning

confidence: 99%

Hemophagocytic lymphohistiocytosis during treatment of intracranial multifocal germinoma: a case report and literature review

Guo,

Liu,

Chen

et al. 2024

Front. Oncol.

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“…Neoplastic masses in the pineal gland are uncommon and a rare clinical entity, with less than 10% of pediatric tumors, and less than 1% of all intracranial tumors. Patients with pineal tumor may present symptoms connected to elevated intracranial pressure, such as headache, nausea, vomiting, and somnolence [13]. The pineal gland is centrally positioned with a very complex relationships, below the splenium of corpus callosum, posterior the third ventricle, above and behind the mesencephalic tectum and medially to the left and right thalamus [4,8].…”

Section: Discussionmentioning

confidence: 99%

Microanatomical study of the posterior medial choroidal artery

et al. 2023

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Introduction/Objective. The aim of this study was a detailed examination of microanatomy of the medial posterior choroidal artery (MPChA). Methods. The microanatomical characteristics of the MPChA were studied in 30 formalin fixed brain hemispheres using ? 6.3 to ? 10 magnification of the stereoscopic microscope. The arteries were injected with the mixture of 10% India ink and gelatin. The second group of 10 hemispheres consisted of specimens injected with methylmethacrylate fluid into the cerebral arterial vessels, for the preparation of corrosion casts. Results. The MPChA was present in all 30 hemispheres, always as the single artery. The MPChA were divided into proximal and distal types of vessels. We distinguished two segments of the MPChA: a cisternal and plexal. Proximal MPChA was present in 53.3% of cases, with the caliber of 0.6-1.0 mm (mean 0.8 mm). ?he point of its origin from the posterior cerebral artery was always before the origin of the first temporal cortical branch. Distal MPChA existed in 46.7% of cases, with the diameter of 0.4-1.0 (mean 0.74 mm). The cisternal segment the most frequently gave of the origin of fine branches to the cerebral crus, medial geniculate body and thalamus. The plexal segment gave rise arteries to the thalamus, and choroid branches for the supply of the choroid plexus of the third ventricle. Anastomoses in the region of the MPChA were found in all of 20 examined brains, most often among the plexal branches. Conclusion. The results describing the microanatomical characteristics of the MPChA may have diagnostic and microsurgical significance.

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Features of Cognitive and Emotional Sphere of a Teenager with Epiphysis Pathology and Concomitant Speech Disorder: An Analysis of a Single Case

Turovskaya

2022

Клиническая И Специальная Психология

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<p style="text-align: justify;">The study of the features of cognitive impairments in various cerebral organic pathologies allows us to understand the role of individual structures of the brain in the implementation of mental activity and determine the appropriate ways of providing psychological assistance to patients. In a situation of rare pathology, the analysis of individual clinical cases is useful. The aim of this research was to study the state of cognitive functions in a 13-year-old male teenager with a cystic restructuring of the pineal gland and concomitant undifferentiated impairment of expressive speech. Changes in the epiphysis were detected in the patient in less than a month before this psychological study. During the examination, methods of pathopsychological and neuropsychological diagnostics, and projective graphic tests were used. In the course of neuropsychological research on a teenager, a violation of the ability to compose a syllabic kinetic scheme of utterance and, in general, a lack of dynamic and kinesthetic praxis, as well as interhemispheric interaction and auditory-speech memory were revealed. The main ways of providing psychological assistance to the patient were identified: neuropsychological correction aimed at restoring impaired speech function based on preserved higher mental functions, and restoration of the communicative function of speech. The obtained results of psychological research require further understanding and verification, primarily in order to understand the pathogenesis of cognitive disorders in the situation of cystic pineal gland rearrangement.</p>

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Mixed germ cell tumor of the pineal gland in a pediatric patient

Cited by 3 publications

References 16 publications

Hemophagocytic lymphohistiocytosis during treatment of intracranial multifocal germinoma: a case report and literature review

Hemophagocytic lymphohistiocytosis during treatment of intracranial multifocal germinoma: a case report and literature review

Microanatomical study of the posterior medial choroidal artery

Features of Cognitive and Emotional Sphere of a Teenager with Epiphysis Pathology and Concomitant Speech Disorder: An Analysis of a Single Case

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