Mixed hepatoblastoma diagnosed by fine‐needle aspiration biopsy cytology: A case report

Jain, Renu

doi:10.1002/(sici)1097-0339(199810)19:4<306::aid-dc17>3.3.co;2-b

Cited by 2 publications

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“…More recently, FNA and CNB have been used to confirm the diagnosis prior to therapy. [18][19][20][21] However, FNA was preferred to CNB because it was judged to be less invasive, minimizing side effects and providing excellent material for immunohistochemistry (on CB) and molecular techniques, if necessary. On the other hand, the use of CNB allowed classification of tumors into different histological subtypes 1 and became reproducible among pathologists.…”

Section: Discussionmentioning

confidence: 99%

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Fine needle aspiration in the diagnosis and classification of hepatoblastoma

Vlajnic

Brisse

Aerts

et al. 2016

Diagnostic Cytopathology

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Section: Discussionmentioning

confidence: 99%

“…N.A. IHC Gupta RK, et al 20 1 HBL Yes IHC Us-Krasovec M, et al 22 15 HBL (12 of 15) 10 of 15 Yes Ers€ oz C, et al 19 2 HBL Yes IHC Jain R, et al 21 1 HBL N.A. N.A.…”

Section: Cytologymentioning

confidence: 99%

Fine needle aspiration in the diagnosis and classification of hepatoblastoma

Vlajnic

Brisse

Aerts

et al. 2016

Diagnostic Cytopathology

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“…Distinct subtypes of the epithelial component include fetal, embryonal, anaplastic (small cell), and macrotrabecular 4, 5. In recent years, the cytologic features of this tumor have been amply elucidated on fine‐needle aspiration (FNA);6–13 however, its exfoliative cytomorphologic characteristics have not been reported. In this series, we describe the cytopathologic features of six serous cavity fluids (SCF) from four patients with histologically proven hepatoblastoma, discuss potential cytologic imitators, and present ultrastructural and cytogenetic data from a selected patient.…”

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confidence: 99%

Hepatoblastoma

Weir

Ali

2002

Cancer

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BACKGROUND Hepatoblastoma (HBL) represents the most common primary hepatic tumor in children. Although the cytologic features of this tumor have been amply elucidated on fine‐needle aspiration, exfoliative cytomorphologic characteristics have not been reported. The authors reviewed the cytopathologic features of six serous cavity fluids (SCF) from four patients with histologically proven HBL. METHODS Five of the specimens evaluated were peritoneal fluids, and one specimen was pleural fluid from a patient with suspected pulmonary metastasis. Slides were prepared by cytocentrifugation and stained with Diff‐Quik and Papanicolaou stains. The cytomorphologic features of each specimen were characterized, subclassified, and correlated histopathologically. RESULTS All specimens showed hypercellular smears in a relatively clean background. Mixed embryonal and fetal subtypes of HBL disclosed three‐dimensional clusters of neoplastic cells that formed straight or branched cords and acinus‐like structures. The cells were moderately pleomorphic and had high nuclear‐to‐cytoplasmic (N/C) ratios. Occasional cells had eccentrically placed nuclei and vacuolated cytoplasm. Numerous mitotic figures were present. Rare intranuclear inclusions were noted. The anaplastic (small cell) subtype of HBL showed tight clusters of small, round, primitive cells with hyperchromatic nuclei, high N/C ratios, and prominent nuclear molding. In addition, there were numerous single cells with naked nuclei, often in an Indian‐file configuration. Bile pigment, osteoid, and other mesenchymal components were absent in all specimens. CONCLUSIONS The cytomorphologic features of HBL in SCF are quite characteristic. Although the differential diagnosis includes other childhood small, round, blue cell tumors and hepatocellular carcinoma, the above findings in the appropriate clinical‐radiologic setting warrant a diagnosis of HBL. Cancer (Cancer Cytopathol) 2002;96:267–74. © 2002 American Cancer Society.

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Mixed hepatoblastoma diagnosed by fine‐needle aspiration biopsy cytology: A case report

Cited by 2 publications

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Fine needle aspiration in the diagnosis and classification of hepatoblastoma

Fine needle aspiration in the diagnosis and classification of hepatoblastoma

Hepatoblastoma

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