Mixed infection by <i>Feline astrovirus</i> and <i>Feline panleukopenia virus</i> in a domestic cat with gastroenteritis and panleukopenia

Moschidou, P.; Martella, Vito; Lorusso, Eleonora; Desario, Costantina; Pinto, Pierfrancesco; Losurdo, Michele; Catella, Cristiana; Parisi, Antonio; Bányai, Krisztiàn; Buonavoglia, Canio

doi:10.1177/1040638711404149

Cited by 22 publications

(18 citation statements)

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“…The term superinfection is used if one virus infects the host some time before infection by the second virus. However, in the literature, the definitions of coinfection and mixed infection have been used interchangeably (2)(3)(4)(5). The meaning of these terms depends on the context, whether applied to a single cell, a cell line, part of a host, or a whole host (1,4).…”

Section: Introductionmentioning

confidence: 99%

“…However, in the literature, the definitions of coinfection and mixed infection have been used interchangeably (2)(3)(4)(5). The meaning of these terms depends on the context, whether applied to a single cell, a cell line, part of a host, or a whole host (1,4). In an infected cell, viruses can interact with a large number of cellular proteins (virus-host interactome) that may either support or inhibit virus replication.…”

Section: Introductionmentioning

confidence: 99%

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Virological and Immunological Outcomes of Coinfections

et al. 2018

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SUMMARYCoinfections involving viruses are being recognized to influence the disease pattern that occurs relative to that with single infection. Classically, we usually think of a clinical syndrome as the consequence of infection by a single virus that is isolated from clinical specimens. However, this biased laboratory approach omits detection of additional agents that could be contributing to the clinical outcome, including novel agents not usually considered pathogens. The presence of an additional agent may also interfere with the targeted isolation of a known virus. Viral interference, a phenomenon where one virus competitively suppresses replication of other coinfecting viruses, is the most common outcome of viral coinfections. In addition, coinfections can modulate virus virulence and cell death, thereby altering disease severity and epidemiology. Immunity to primary virus infection can also modulate immune responses to subsequent secondary infections. In this review, various virological mechanisms that determine viral persistence/exclusion during coinfections are discussed, and insights into the isolation/detection of multiple viruses are provided. We also discuss features of heterologous infections that impact the pattern of immune responsiveness that develops.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Virological and Immunological Outcomes of Coinfections

et al. 2018

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“…FPV, a member of the species Carnivore protoparvovirus 1, which belongs to the genus Protoparvovirus within the family Parvoviridae, is a highly contagious pathogen in domestic and wild cats [1]. FPV is transmitted by the faecal-oral route and primarily infects young kittens aged 3-6 months [15,21], resulting in severe enteric and immunosuppressive diseases characterized by fever, depression, anorexia, vomiting, acute diarrhea, haemorrhagic enteritis and leukopenia [16]. At present, FPV is widely spread throughout the world, with a high mortality rate of 25% to 90% [18], 1 3 and represents a serious threat to the life and health of cats.…”

Section: Introductionmentioning

confidence: 99%

“…PCR has become the most widely used method for detection of pathogens due to its high sensitivity and specificity. Routine PCR/RT-PCR methods for detection of FPV, FeAstV and FBoV have been described in previous reports [12,16], but ? ?there have been no reports of??…”

Section: Introductionmentioning

confidence: 99%

Development and application of a multiplex PCR method for the simultaneous detection and differentiation of feline panleukopenia virus, feline bocavirus, and feline astrovirus

Zhang

Niu

et al. 2019

Arch Virol

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A multiplex polymerase chain reaction (mPCR) assay was developed to detect and distinguish feline panleukopenia virus (FPV), feline bocavirus (FBoV) and feline astrovirus (FeAstV). Three pairs of primers were designed based on conserved regions in the genomic sequences of the three viruses and were used to specifically amplify targeted fragments of 237 bp from the VP2 gene of FPV, 465 bp from the NP1 gene of FBoV and 645 bp from the RdRp gene of FeAstV. The results showed that this mPCR assay was effective, because it could detect at least 2.25-4.04 × 10 4 copies of genomic DNA of the three viruses per μl, was highly specific, and had a good broad-spectrum ability to detect different genotypes of the targeted viruses. A total of 197 faecal samples that had been screened previously for FeAstV and FBoV were collected from domestic cats in northeast China and were tested for the three viruses using the newly developed mPCR assay. The total positive rate for these three viruses was 59.89% (118/197). From these samples, DNA from FPV, FBoV and FeAstV was detected in 73, 51 and 46 faecal samples, respectively. The mPCR testing results agreed with the routine PCR results with a coincidence rate of 100%. The results of this study show that this mPCR assay can simultaneously detect and differentiate FPV, FBoV and FeAstV and can be used as an easy, specific and efficient detection tool for clinical diagnosis and epidemiological investigation of these three viruses.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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“…Because of their genetic diversity and recombination ability, astroviruses have the potential for zoonosis (5). Although feline astroviruses (FAstVs) have also been detected in the feces of cats with and without diarrhea (6)(7)(8)(9), no complete genome sequence of a FAstV is available. In March 2012, we discovered a novel feline astrovirus, FAstV2 strain 1637F, which is closely related to human astroviruses (HAstVs), from a fecal sample from an asymptomatic domestic cat (Felis catus) in Hong Kong, and its complete genome was sequenced.…”

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confidence: 99%