Production scheduling is defined as a problem of allocating jobs in machines in a production environment and it has been largely studied. The scheduling can vary in difficulty and complexity depending on the environment, the variety and types of technological restraints and the objective function of the problem. The use of decision making methods to solve scheduling problems in the industry needs models that are capable to solve real problems, that usually involve a big variety of restraints that have to be simultaneously studied. At the present work the scheduling problem in a permutational flow shop environment, considering blocking with zero buffer, and sequence and machine dependent setup times, with the objective of minimizing makespan is studied, which is considered a NP-Complete problem and little explored in literature. The work presents a calculation procedure for the makespan and three solution methods for the problem: four lower bounds for the Branch-and-Bound procedure; four MILP models, two of which are adapted; and 28 constructive heuristic methods adapted to the problem. The methods developed are based on mathematical properties of the problem that are presented in this work as a lower bound and an upper bound. Among all the MILP models, the adapted model RBZBS1 was the one to obtain the best results for the smaller problems, and the developed model TNZBS1 obtained the smallest mean relative deviation of the makespan for the bigger problems that were not solved within the specified computational time limit. The lower bound for the Branch-and-Bound LB TN2 obtained smaller computational times and number of explored nodes as well as the number of unsolved problems and the mean relative deviation for the makespan than all other lower bounds. Also, a comparison among the best MILP model and the best lower bound for the Branch-and-Bound was performed, being that the last obtained better results for the tested problems. Among the adapted heuristic methods, the PF heuristic was the one that obtained, in general, the better results in all phases.