Mixed interleukins and thymosin fraction V synergistically induce T lymphocyte development in hydrocortisone-treated aged mice

Hadden, Elba M.; Malec, P; Sosa, Marina; Hadden, John W.

doi:10.1016/0008-8749(92)90239-l

Cited by 20 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings of animal studies 21 convinced us that IRX-2 has activity that is not shared by recombinant cytokines, even the mixture of rIL-1 and rIL-2. We therefore consider the natural mixture critical to the success of this protocol.…”

Section: 10mentioning

confidence: 79%

Combination Immunotherapy of Squamous Cell Carcinoma of the Head and Neck

Barrera¹,

Verástegui²,

Meneses³

et al. 2000

Arch Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

Section: 10mentioning

confidence: 79%

Combination Immunotherapy of Squamous Cell Carcinoma of the Head and Neck

Barrera¹,

Verástegui²,

Meneses³

et al. 2000

Arch Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…In addition, TF5 enhanced IL-6 production in spleen cells in vitro (Attia et al 1993). Hadden et al (1992) reported that TF5 injections potentiated the ability of an interleukin cocktail administered in vivo to enhance the recovery of function in vitro of lymphocytes obtained from glucocorticoid-treated mice. The preparation also tended to normalize the abnormalities in thymic weight and thymocyte subpopulations associated with severe uremia, as noted above (Ikemoto et al 1992).…”

Section: Introductionmentioning

confidence: 98%

The thymic-endocrine connection

Spangelo¹

1995

Journal of Endocrinology

View full text Add to dashboard Cite

“…Other agerelated modifications include an imbalance in cytokine profiles [6][7][8][9][10], production of hormones [11], and defective signal transduction pathways due to the impairment of Ca 2þ mobilization and the activation of protein kinases [12,13]. In addition, the involution of the thymus [14] may also have a role in this process as the output of new T cell emigrants declines considerably with age resulting in an accumulation of memory T cells [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Increased Mortality and Impaired Clonal Deletion After Staphylococcal Enterotoxin B Injection in Old Mice: Relation to Cytokines and Nitric Oxide Production

et al. 1997

View full text Add to dashboard Cite

Kuschnaroff LM, Goebels J, Valckx D, Heremans H, Matthys P, Waer M. Increased Mortality and Impaired Clonal Deletion After Staphylococcal Enterotoxin B Injection in Old Mice: Relation to Cytokines and Nitric Oxide Production. Scand J Immunol 1997;46:469-478 In the present study peripheral T cell tolerance and the occurrence of shock were evaluated in young and old mice after injection of Staphylococcal enterotoxin B (SEB). In young mice SEB immunization leads to tolerance based on deletion and anergy of SEB-reactive Vb8 þ T cells. With aging, mice developed resistance to SEB-induced deletion of Vb8 þ T cells as well as a high sensitivity to toxic shock. Compared to young mice, older mice injected with SEB showed increased serum levels of interferon-g (IFN-g), interleukin-2 (IL-2) and IL-4. These results were confirmed by reverse transcription-polymerase chain reaction (RT-PCR), as splenic mRNA levels taken 2 h after SEB injection showed higher values of IL-2, IL-4, and IFN-g in old mice. In contrast, mRNA levels for FasL and tumour necrosis factor-a (TNF-a) were lower. No difference in IL-10 mRNA was found. Compared to young mice, old mice showed a high, but statistically not significantly different (P ¼ 0.20), production of nitric oxide (NO). Blocking of IFN-g with antibodies or reducing IFN-g by depletion of natural killer (NK) cells resulted, respectively, in a complete or partial protection against mortality in aged mice. Suppressing the NO production by the NO synthase inhibitor N-nitro-L-arginine methylester (L-NAME) increased the mortality in both young and old mice, and abrogated clonal deletion in the surviving young mice. In conclusion, in young mice NO production is a key factor in the protection against mortality and the development of clonal deletion after SEB injection. The higher mortality seen in older mice is mainly related to the elevated production of IFN-g and occurs despite a sufficient production of NO. The decreased clonal deletion of old mice may be related to their decreased expression of Fas ligand or TNF-a after SEB injection.

show abstract

Mixed interleukins and thymosin fraction V synergistically induce T lymphocyte development in hydrocortisone-treated aged mice

Cited by 20 publications

References 18 publications

Combination Immunotherapy of Squamous Cell Carcinoma of the Head and Neck

Combination Immunotherapy of Squamous Cell Carcinoma of the Head and Neck

The thymic-endocrine connection

Increased Mortality and Impaired Clonal Deletion After Staphylococcal Enterotoxin B Injection in Old Mice: Relation to Cytokines and Nitric Oxide Production

Contact Info

Product

Resources

About