Mixed ligand complexes of copper(II) with benzoyltrifluoroacetone, 1,10-phenanthroline and 2,2′-bipyridine: Structure, spectroscopic and antimicrobial properties

Mixed-ligand complexes of copper(ii) with thienoyltrifluoroacetonate and nitrogen containing ligands: synthesis, structures, antimicrobial activity, cytotoxicity, Hirshfeld surface analysis and DFT studies

“…All complexes were various shades of green in colour, except [Cu(TTA)(tmen)]NO 3 which was dark blue in colour. The molar conductivities of the complexes are low with Λ m values in the range of 34–47 ohm −1 cm 2 mol −1 , which suggest that they are non-electrolytes 48–50 except [Cu(TTA)(tmen)]NO 3 which is a 1 : 1 electrolyte.…”

“…62,64 Hence, a minor shi to higher frequency of the ligand eld spectral band in a coordinating solvent such as methanol relative to a non-coordinating solvent for copper(II) species in solution is indicative of a probable transformation from vecoordinate square pyramidal copper(II) environment to sixcoordinate environment upon coordination of such solvents as methanol. 49,50,63 Thus, complexes 1-5 have square-pyramidal geometry due to higher energy shis in methanol relative to chloroform. The intraligand p-p* and ligand to metal charge transfer (LMCT) transitions are observed in the 28 249-50 000 cm À1 region for the synthesized complexes.…”

Multi-target activity of copper complexes: Antibacterial, DNA binding, and molecular docking with SARS-CoV-2 receptor

“…It is well known that chelation is not the only criterion for antibacterial activity. Some important factors such as the nature of the metal ion, the nature of the ligand, the coordinating sites, the geometry of the complex, the concentration, hydrophilicity, lipophilicity, and the presence of co-ligands have a considerable influence on the antibacterial activity [ [34] , [35] , [36] ]. Complexes containing heterocyclic ligands have a more possibility of interacting with nucleoside ases [ 37 ].…”

Exploring the BSA- and DNA-binding, cytotoxicity, and cell cycle evaluation of ternary copper(ii)/diimine complexes with N,N-dibenzyl-N′-benzoylthiourea as promising metallodrug candidates

“…9,10 Many studies have shown that N-heterocyclic ligands can increase the complex cell uptake, inducing apoptotic process, which increases the complexes' antitumor activity. [11][12][13] Furthermore, acylthioureas, also versatile ligands, may form several metal complexes with a wide range of biological applications. [14][15][16] Given this, the complexes of copper(II) and acylthioureaderived ligands show promising biological properties.…”